Abstract: Systems and methods are provided for removing an obstruction from a ureter using a catheter including a distal end sized for introduction into a ureter, an infusion lumen, and an aspiration lumen. An infusion tip is provided on the distal end that includes infusion ports communicating with the infusion lumen, and one or more aspiration ports communicating with the aspiration lumen. One or more sources of fluid and/or vacuum are connectable to the tubular member such that fluid is delivered into the infusion lumen and suction is delivered into the aspiration lumen. A controller is coupled to the source(s) to control delivery of fluid to generate a radially outward pressure against a wall of a ureter adjacent the infusion tip and to control suction through the aspiration port(s) to apply a suction force against a kidney stone located adjacent the infusion tip.