Abstract: Provided are methods, devices and systems that utilize free-surface fluidics and SERS for analyte detection with high sensitivity and specificity. The molecules can be airborne agents, including but not limited to explosives, narcotics, hazardous chemicals, or other chemical species. The free-surface fluidic architecture is created using an open microchannel, and exhibits a large surface to volume ratio. The free-surface fluidic interface can filter interferent molecules, while concentrating airborne analyte molecules. The microchannel flow enables controlled aggregation of SERS-active probe particles in the flow, thereby enhancing the detector's sensitivity.

Abstract: Various aspects of the present disclosure are directed toward apparatus, methods, and articles of manufacture for simulating a physical phenomenon characterized by a set of partial differential equations that are reduced based on harmonic time dependence. The system of linear equations represent an operation in the differential equations, and are characterized by a coefficient matrix multiplied by an unknown column vector, with the product thereof being equal to a column vector. The system of linear equations is solved using at least one of three sets of operations.

Abstract: A method according to an embodiment of the present invention infers a network of information dependence in real-time by capturing the manner in which computer users interact with files. For example, in an embodiment, such dependencies are represented as a sparse directed network. In another embodiment of the present invention, In another embodiment of the present invention, the dependencies are embedded in an operating system or document management system at a level commensurate with the manner in which professionals use Windows Explorer.

Abstract: A high-bandwidth AFM probe having a diffraction grating characterized by a diffraction characteristic that monotonically changes along the length of the diffraction grating is disclosed. AFM probes in accordance with the present invention are capable of high-sensitivity performance over a broad range of operating conditions, such as operating wavelength and measurement media. A method for estimating at least one physical property of a surface based on high-frequency signal components in the output signal from a high-bandwidth AFM probe is also disclosed. The method enables determination of tip-surface interaction forces based on the relationship between a first motion of the base of the AFM probe and a second motion of the tip of the AFM probe.

Abstract: Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated NpHR-based molecule comprising a nucleic acid sequence that codes for light-activated NpHR-based molecule and a promoter. Either a high expression of the molecule manifests a toxicity level that is less than about 75%, or the light-activated NpHR-based proteins are expressed using at least two NpHR-based molecular variants. Each of the variants characterized in being useful for expressing a light-activated NpHR-based molecule that responds to light by producing an inhibitory current to dissuade depolarization of the neuron. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion pumps or for controlling inhibitory currents in a cell (e.g., in in vivo and in vitro environments).

Abstract: As visual recognition scales up to ever larger numbers of categories, maintaining high accuracy is increasingly difficult. Embodiment of the present invention include methods for optimizing accuracy-specificity trade-offs in large scale recognition where object categories form a semantic hierarchy consisting of many levels of abstraction.

Abstract: The therapeutic system of the preferred embodiments includes a foot platform having a lateral segment and a medial segment. The foot platform is coupled to the foot of the patient and supports the body force of the patient. The foot platform functions to move the foot from an equilibrium position to an activated position. The transition of the foot between equilibrium position and activated position, preferably occurs substantially instantaneously once the foot platform supports greater than substantially half of the body force.

Abstract: The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.

Abstract: Various aspects as described herein are directed to piezoelectric materials. As consistent with one or more embodiments, an apparatus includes a nanomaterial and structures coupled to the nanomaterial. This nanomaterial-structure combination manifests piezoelectric characteristics, via the combination. In certain implementations, neither the nanomaterial nor the coupled structures independently exhibit piezoelectric characteristics, yet do so in combination.

Abstract: A method for imaging a scan region by controlling at least one of the relative phase and relative amplitude of multiple optical modes propagating through a multimode optical fiber to control the position of an output beam emitted from the output facet of the optical fiber is disclosed.

Abstract: Aspects of the present disclosure are directed towards far-red monomeric fluorescent proteins that have a high level of brightness such that the proteins are visible over the autofluorescence aspects of tissue. In certain embodiments, the fluorescent proteins are derived from Entacmeae quadricolor. The fluorescent proteins are implantable in the cell and can be excited by light of at least 600 nm.

Abstract: A vertical cavity surface emitting laser (VCSEL) nanoscope is provided. The VCSEL nanoscope combines a VCSEL with a nano-scale aperture using a support member to separate the aperture from the VCSEL emission face. The resulting device is a useful near-field probe with a wide variety of applications.

Abstract: Low loss optical apertures are provided. A silicon intermediate layer sandwiched between a metal aperture layer and a dielectric layer has been found to offer a good combination of low optical loss combined with superior mechanical properties.

Abstract: An optical sensor, a method of configuring an optical sensor, and a method of using an optical sensor are provided. The optical sensor includes an optical loop having a length and a laser source optically coupled to the loop. The laser source has a coherence length. Light from the source is transmitted to the loop as a first signal and a second signal counterpropagating along the loop. The optical paths of the first signal and the second signal are substantially reciprocal with one another and the first signal and the second signal are combined together after counterpropagating through the loop to generate a third signal. A ratio of the coherence length to the length of the loop is greater than 1.

Abstract: Provided herein are methods for the treatment of bladder dysfunction, including detrusor hyperreflexia and detrusor external sphincter dyssynergia, fecal incontinence, and/or sexual dysfunction in an individual via the use of stably expressed light-responsive opsin proteins capable of selective hyperpolarization or depolarization of the neural cells that innervate the muscles responsible for physiologic functioning of urinary bladder, external urinary sphincter, external anal sphincter, and the male and female genitalia.

Abstract: Electromagnetic energy transfer is facilitated. In accordance with an example embodiment, a first resonator transmits electromagnetic energy using an electromagnetic wave, based on frequency matching and alignment of an electromagnetic field with a second resonator within one wavelength of the electromagnetic wave distance from the first resonator. An electromagnetic energy reflector adjacent the first resonator redirects reflected portions of the electromagnetic wave back towards the first resonator circuit.

Abstract: Embodiments of the invention provide a high energy photon detector. A first scintillation crystal is provided. A first plurality of photosensors is on a first face of the first scintillation crystal, wherein the first plurality is at least two. A second scintillation crystal is provided. A second plurality of photosensors is on a first face of the second scintillation crystal, wherein the second plurality is at least two. An optical coupling interface is between a second face of the first scintillation crystal and a second face of the second scintillation crystal, wherein the optical coupling interface provides an optical transmission between the first scintillation crystal and the second scintillation crystal, so that the distribution of scintillation light created in one crystal is allowed to spread into the second crystal.

Abstract: Intersecting photonic crystal structures provide overlapping cavity modes that can have widely separated resonant frequencies. These photonic crystal structures can be either 1-D photonic crystal structures or 2-D photonic crystal structures. If a material having the zincblende crystal structure is employed (e.g., GaAs), it is preferred for the crystal orientation to be (110) or (111), because these orientations can provide three wave mixing for three TE-like modes.

Abstract: Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules. Using a light pulse, the light-responsive molecules in the target neural cell population are stimulated. Multiple regions of the brain are scanned via magnetic resonance imaging. The scans allow for observation of a neural reaction in response to the stimulation in at least one of the multiple regions of the brain.

Abstract: Various aspects are directed to systems and methods for assessing neural activity of a neural region having multiple subfields. In certain embodiments, a method includes evoking a cellular electrical response in at least one subfield due to neural activity in the neural region, capturing image data of the electrical response at a level sufficiently detailed in space and time to differentiate between polarization-based events of two respective portions of the subfield, and then assessing neural activity by correlating space and time information, from the captured data, for the two respective portions of the sub-field. Other more specific aspects of the invention involve different preparation and neural stimulation approaches which can vary depending on the application.