Abstract: Provided herein are methods of determining a subject's need for an implanted cardiac defibrillator, methods of determining a subject's risk for sudden cardiac death (SCD), arrhythmias, or heart failure, methods of determining a subject's need for an anti-arrhythmic agent, e.g., a sodium channel blocker, and methods of reducing risk of SCD in a subject. In exemplary embodiments, each of the methods comprise the step of determining a ratio, RS, which compares a level of a truncated SCN5A Exon 28 transcript of a biological sample obtained from the subject to (i) a level of a full length SCN5A Exon 28 transcript of the biological sample or (ii) a level of all SCN5A Exon 28 transcripts of the biological sample or (iii) a level of a full length SCN5A Exon 28 transcript and a level or one or more truncated SCN5A Exon 28 transcripts.

Abstract: Methods for quantifying, adjusting or terminating a dose of a therapeutic intervention applied to tissue of a patient. A therapeutic intervention of a specified intensity is applied to a region of interest of the tissue. The tissue is mechanically excited, typically concurrently with the therapeutic intervention, and the region of interest is scanned optically or ultrasonically at the same time. An interference signal is acquired by coherently detecting post-interaction illumination arising in the region of interest by interfering the post-interaction illumination with a reference beam derived from the identical source as that of the scanning. A phase and/or amplitude of response of the tissue relative to the mechanical excitation based on the interference signal. A spatially resolved measure of a property of the region of interest is derived based on the phase of response, allowing for adjustment or termination of the therapeutic intervention.

Abstract: A method for indirectly monitoring and controlling an electrically resistive adsorption system. Adsorption of a predetermined adsorbate is conducted while indirectly monitoring electrical resistance of a unified adsorbent element. Breakthrough is predicted based upon the indirectly monitored electrical resistance and a previously measured mass loading relationship between the resistance of the unified adsorbent element and the loading of the unified resistance element with the predetermined adsorbate. Adsorption, regeneration and cooling cycles are controlled by a controller without any direct measurement of temperature or resistance of the element and characterizations of mass loading and temperature. Systems of the invention can have no sensors that contact the element, are in an adsorption vessel, and/or are downstream adsorption vessel.

Abstract: The invention provides agents, compositions, pharmaceutical compositions and method for inhibiting tumor cell proliferation by inhibiting FoxM1B activity, expression, or nuclear localization in a tumor cell.

Abstract: Methods and a computer readable medium for deriving a quantitative phase contrast tomographic image of a specimen. The specimen is illuminated and a focus of the illuminating light is scanned to a plurality of depths within the specimen. Light transmitted through the specimen is spatially Fourier transformed at each of the plurality of depths to form a spatially transformed image, and at least one of the phase and amplitude of a plurality of spatial frequency components of the spatially transformed image is spatially modulated. An intensity image of the specimen plane as modulated with respect to spatial frequency components is detected and deconvolved at a plurality of spatially modulated instances to obtain a three-dimensional phase representation of the specimen at each of the plurality of distances relative to a fiducial plane.

Abstract: A system utilizes a Single Instruction Multiple Data (SIMD) processor to efficiently determine, in parallel, the optimal global alignment for multiple input sequence pairs. The system may partition a score matrix generated for the input sequence pair into multiple sectors. While determining the cell content for each of the cells in the score matrix, the system may selectively retain computed cell contents for upper and left boundary cells of the partitioned sectors. During a traceback process, the system may retrieve the retained boundary cells for a current sector and recompute the cell contents for the current sector. Then, the system may determine the traceback path for the current sector. The system may continue to process sectors one at a time until the traceback path for the score matrix, and accordingly the optimal global alignment for the input sequence pair, is determined.

Abstract: A method for monitoring construction progress may include storing in memory multiple unordered images obtained from photographs taken at a site; melding the multiple images to reconstruct a dense three-dimensional (3D) as-built point cloud model including merged pixels from the multiple images in 3D space of the site; rectifying and transforming the 3D as-built model to a site coordinate system existing within a 3D as-planned building information model (“as-planned model”); and overlaying the 3D as-built model with the 3D as-planned model for joint visualization thereof to display progress towards completion of a structure shown in the 3D as-planned model. The processor may further link a project schedule to the 3D as-planned model to generate a 4D chronological as-planned model that, when visualized with the 3D as-built point cloud, provides clash detection and schedule quality control during construction.

Abstract: The present invention is directed to a multi-angulated catheter and methods of using the multi-angulated catheter. The multi-angulated catheter is so dimensioned as to facilitate accessing the left ventricle from an arm of a patient. The multi-angulated catheter generally includes in order: (a) a coiled end; (b) a first straight portion having a first straight portion length; (c) a first shaft including a distal end connected to the first straight portion and a proximal end opposite the distal end, the first shaft and the first straight portion defining a first obtuse angle, the first shaft having a first shaft length; and (d) a second shaft connected to the first shaft on said proximal end. The catheter is flexible so as to afford being straightened when it is advanced over a guide wire. The catheter resiliently returns to a multi-angulated position after the guide wire is withdrawn.

Abstract: Methods to sensitize tumor cells to radiation therapy through the administration of an endothelin agonist such as the ETB agonist IRL1620.

Abstract: This invention provides methods and compositions of hematopoietic progenitor cells and hematopoietic stem cells, particularly methods for expanding populations of these cells types from biological sources.

Abstract: Methods for estimating a conditional probability distribution for signal states of a non-linear random dynamic process. The filter is based on multiple particles, each defined by a state space model similar to the dynamic process. Each particle is updated on the basis of a control input derived by proportional gain feedback on an innovation process. The innovation process is the difference between an increment in an observed quantity measured by one or more sensors and an average of a function of the particles. The particle filter of the invention may also be applied to filtering problems with data association uncertainty where multiple measurements are obtained, of which at most one originates from a specified target.

Abstract: Power balancing techniques are provided for improving power efficiency of pipelined processors. A design-level implementation can be incorporated during synthesis of pipeline clocks in which a register transfer level (RTL) code, operating frequency, and available voltage domains are used to perform cycle time stealing with, and optimize for, power efficiency. A test-level implementation can be incorporated during testing of a chip in which delay and power measurements are used to perform calculations based on cycle time stealing and optimization of power efficiency. The calculations are then used to perform voltage scaling and/or adjust tunable delay buffers. Process variations may also be corrected during test time. A run-time approach can be incorporated for dynamic power balancing in which the operating system keeps track of one or more performance indicators such as a count of floating point instructions and uses a look-up table to provide the appropriate delays.

Abstract: A peer to peer network includes multiple communication layers, each specifying a path through which network peers send data through the peer to peer network. A network peer in the peer to peer network may receive data from a parent network peer and send data to a child network peer. The network peer may identify communication interruption caused by the child network peer and a subsequent downstream network peer leaving the peer to peer network. The network peer may resolve the communication interruption by identifying a new child peer, for example, by accessing a descendant list of multiple levels. The peer to peer network may increase the streaming rate or streaming quality using the peers that have higher or better communication capacities. The peer to peer network may accommodate multiple channels for video/audio or other types of real-time data broadcasted by different or same network peers.

Abstract: Methods and compositions for contributing to the treatment of cancers, especially ovarian tumors, are disclosed. The methods and compositions utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of chemotherapeutic agent(s) (e.g., cisplatin and/or cyclophosphamide).

Abstract: The present disclosure provides compositions and methods related to the fermentation of xylose. Host cells having recombinant polynucleotides encoding one or more of aldose reductases, xylitol dehydrogenases, and xylulokinase are provided herein. Host cells having reduced expression of PHO13 are also provided herein. Also provided herein are uses of host cells provided herein, and methods relating to the use of xylose-containing materials.

Abstract: Methods, compositions and articles of manufacture for contributing to the treatment of cancers, including solid tumors, are disclosed. The methods, compositions and articles of manufacture can utilize an endothelin B agonist (ETB) to enhance the delivery and resulting efficacy of a chemotherapeutic agent.

Abstract: The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

Abstract: An opto-electronic oscillator circuit, including: an opto-electronic circuit loop including an optical modulator that receives a first electrical signal and produces an optical output signal coupled with an optical resonator, a photodetector circuit optically coupled with the optical resonator, and a phase shifter coupled with the photodetector circuit for producing a phase shifted output signal that is fed back as the first electrical signal; an optical loop comprising the optical coupling of the optical resonator with the photodetector; and an electrical feedback circuit loop for coupling the first electrical signal with the photodetector circuit.

Abstract: Embodiments of a method to use nucleic acid oligomer sequences for modulating the shape of nanoparticles are disclosed, as well as nanoparticles and methods of using the nanoparticles. Systematic variations of the nucleic acid sequences offer mechanistic insights into the morphology control. A plurality of nucleic acid oligomers is adsorbed onto a metal nanoseed to provide an oligomer-functionalized nanoparticle. Additional metal is deposited onto the oligomer-functionalized nanoparticle to produce a shaped nanoparticle having a morphology based at least in part on the nanoseed morphology and the oligomer's sequence composition. Embodiments of methods for using the shaped nanoparticles also are disclosed.