Abstract: Embodiments of an expandable sheath can be used in conjunction with a catheter assembly to introduce a prosthetic device, such as a heart valve, into a patient. Such embodiments can minimize trauma to the vessel by allowing for temporary expansion of a portion of the introducer sheath to accommodate the delivery apparatus, followed by a return to the original diameter once the prosthetic device passes through. Some embodiments can include a sheath with inner and outer layers, where a folded portion of the inner layer extends through a slit in the outer layer and a portion of the outer layer overlaps the folded portion of the inner layer. Some embodiments include an elastic outer cover positioned outside the outer layer. Embodiments of the present expandable sheath can avoid the need for multiple insertions for the dilation of the vessel, thus offering advantages over prior art introducer sheaths.

Abstract: An embodiment includes extracting, by a scheduler, function-tag data associated with a function identified by a deployment request. The embodiment also includes selecting, by the scheduler, a computing device within a server cluster to host the function based at least in part on a comparison of the function-tag data and host-tag data associated with the computing device. The embodiment also includes issuing, by the scheduler, an instruction to the computing device, wherein the issuing of the instruction causes an allocation of resources for hosting execution of the function.

Abstract: According to various embodiments, a printed circuit board includes: a buried via formed through one or more layers of the printed circuit board; a first conductive pad that is formed on a first end of the buried via; a first conductive via that is formed through a first layer of the printed circuit board and is connected to the first conductive pad; and a second conductive via that is formed through the first layer of the printed circuit board and is connected to the first conductive pad.

Abstract: A method for redundant control in a distributed automation system, preferably a real-time automation system, for operating a client device of the distributed automation system is discussed. The method includes using the client device to monitor for the occurrence of a fault in communication between the client device and a first computing infrastructure that is part of the distributed automation system and operates the client device. The method may also include using the client device, once the fault occurs, to instruct a second computing infrastructure of the distributed automation system to operate the client device.

Abstract: Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (PE), deep vein thrombosis (DVT), cerebrovascular embolism, and other vascular occlusions. The capture system can include a tubular body comprising a first end, a second end, and an axial length therebetween, the first end having an opening and a capture guide. The capture system can include one or more tensioners coupled to the capture guide. The tubular body has a first configuration in which the first end and the capture guide are expanded while the second end and a majority of the tubular body remains compressed. The tubular body is transformable to a second configuration by application of tension by the tensioners. The catheter can remove a large volume of clot. In some embodiments, the body of the catheter or the funnel tip is expandable. The catheter can include a dilator and a peel-away cover.

Abstract: The present disclosure relates to, among other things, methods for degrading targeted surface proteins using the ubiquitin pathway by using a bispecific binding agent or an immunoconjugate that binds the targeted surface protein and a membrane-associated ubiquitin E3 ligase. The present disclosure also relates to methods for degrading targeted surface proteins using the ubiquitin pathway using an engineered transmembrane protein that binds the targeted surface protein and exhibits ubiquitin E3 ligase activity. The disclosure also provides compositions and methods useful for producing such bispecific binding agents and engineered transmembrane proteins, immunoconjugates, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various diseases such as cancers.

Abstract: Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for a cardiovascular device, then return to a non-expanded state after the passage of the device. The sheath includes an elongated annular member through which the cardiovascular device and its delivery system pass. In an embodiment, the annular inner member can be formed by coextruding a first and second material. The first material includes a fold, and the second material radially spaces the different parts of the fold from each other during fabrication and provides support for maintaining the tubular structure. The second material is removed once the coextrusion process is complete.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: The present description concerns a support (54) for semiconductor substrates (26) comprising an assembly of trays (58A, 58B, 58C, 58D) having the semiconductor substrates resting thereon. Each tray is made of an electrically-conductive material and has at least one substantially vertical surface having locations arranged in at least two horizontally-oriented rows and two vertically-oriented columns. Each location receives a semiconductor substrate oriented with an inclination relative to a vertical direction varying from 1° to 10°. Each tray comprises, at each location, a recess or a cavity covered with the substrate (56). The trays of each pair of trays facing each other are separated by electrically-insulating spacers (60).

Abstract: A matching network for a system having a non-linear load and powered by a first RF power supply operating at a first frequency and a second RF power supply operating at a second frequency. The matching network includes a first matching network section for providing an impedance match between the first power supply and the load. The matching network also includes a second matching network section for providing an impedance match between the second power supply and the load. The first matching network section includes a first variable reactance, and the variable reactance is controlled in accordance with IMD sensed in the signal applied to the load by the first RF power supply. The variable reactance is adjusted in accordance with the IMD to reduce the detected IMD.

Abstract: An electrosurgical generator arranged to supply radio frequency (RF) energy to fuse tissue is provided. The generator is arranged to supply RF energy through a removably coupled electrosurgical instrument to fuse tissue grasped by the instrument. The generator monitors a phase angle of the supplied RF energy and adjusts or terminates the supplied RF energy based on the monitored phase angle in comparison to predetermined thresholds and conditions to optimally fuse the tissue. The electrosurgical instrument conducts radio frequency energy to fuse tissue captured between the jaws and a blade to mechanically cut tissue between the jaws. A conductive post positioned on the jaw adjacent to the blade.

Abstract: Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism, deep vein thrombosis, cerebrovascular embolism, and other vascular occlusions. The capture system can include a tubular body comprising a first end, a second end, and an axial length therebetween, the first end having an opening and a capture guide. The capture system can include one or more tensioners coupled to the capture guide. The tubular body has a first configuration in which the first end and the capture guide are expanded while the second end and a majority of the tubular body remains compressed. The tubular body is transformable to a second configuration by application of tension by the tensioners. The catheter can remove a large volume of clot.

Abstract: Amine functionalized nanoparticles comprising a core-shell nanoparticle morphology comprising a trialkoxyorganosilane coated nanoparticle core and an amine functionalized group on the surface of the nanoparticle as a shell are disclosed, wherein the nanoparticle has an average particle size from about 1 nm to about 1000 nm. Methods and applications of use of the amine functionalized nanoparticles and compositions comprising the amine functionalized nanoparticles dispersed in an aqueous medium are also disclosed.

Abstract: The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

Abstract: Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for a cardiovascular device, then return to a non-expanded state after the passage of the device. The sheath includes an elongated annular member through which the cardiovascular device and its delivery system pass. In an embodiment, the annular inner member can be formed by coextruding a first and second material. The first material includes a fold, and the second material radially spaces the different parts of the fold from each other during fabrication and provides support for maintaining the tubular structure. The second material is removed once the coextrusion process is complete.

Abstract: An electrosurgical system is provided and includes a bipolar electrosurgical instrument and an electrosurgical generator. The bipolar electrosurgical instrument is arranged to seal and cut tissue captured between jaws of the bipolar electrosurgical instrument. The electrosurgical generator is arranged to supply RF energy through the bipolar electrosurgical instrument, monitor the supplied RF energy, and adjust or terminate the supplied RF energy to optimally seal the tissue.

Abstract: Introduced here are approaches to improving the coverage of mesh networks that involve repurposing consumer electronic devices as nodes. By repurposing consumer electronic devices that are configured for a Wi-Fi wireless network protocol, the “dead spot” issue that plagues traditional wireless networks can be addressed at minimal cost.

Abstract: Systems, apparatus, and methods for channel estimation and data detection. In one exemplary embodiment, the data is obtained in a two-phase transmission structure that alternates known data with unknown data according to a regular or otherwise pre-determined time interval. Then, the receiver iteratively updates a postulated channel, and provides a predicted channel to the next time slot. Conceptually, the exemplary techniques iteratively improve its postulates for channel condition and data over multiple time slots. More directly, instead of linear detection and decoding of a pilot for channel estimation in each time slot, the exemplary techniques described herein use postulated channel conditions to attempt data detection and use the recovered data from data detection (unknown data) to re-postulate the channel conditions, etc. until channel conditions are stable and/or the next time slot is ready for processing.

Abstract: An amplifier system with high gain, compact size, and extended bandwidth is disclosed. The amplifier system includes one or more inputs configured to receive one or more input signals and a pre-driver configured to receive the one or more input signals. The pre-driver may comprise source connected FETs which create a virtual ground and may include inductors which cancel or counter parasitic capacitance of the FETs. The pre-driver amplifies the one or more input signals to create one or more pre-amplified signals, which are provided to a voltage divider network configured to reduce a DC bias voltage of the one or more pre-amplified signals, while maintaining a wide bandwidth range. An amplifier receives and amplifies the output of the voltage divider network to create amplified signals. The amplifier may comprise mirrored FET pairs in a common source configuration and a common gate arrangement.

Abstract: Computer-implemented methods and systems for integrating computer applications are disclosed. One method includes querying a primary computer application for current state of a newly created object; receiving the current state of the object, and generating object data for a secondary computer application based on the current state of the object. The method further includes communicating an object creation request to a secondary computer application, the object creation request including the generated object data, receiving a secondary computer application object identifier from the secondary computer application upon creation of the object at the secondary computer application, and communicating the secondary computer application object identifier to the primary computer application for storing in a record of the object created at the primary computer application.