Abstract: Fluorescent bioprobes comprising fluorogen formed nanoparticles comprising fluorogens with aggregation-induced emission (ATE) properties, which can be used for long-term cell tracking. The fluorogens are nonemissive in organic solution but become highly emissive when aggregated in aqueous solution. The fluorescent molecules can readily pass through cell membranes, stain only the cell cytoplasm, and form highly emissive nanoaggregates in aqueous media without any obvious cytoxicity in the living cells. Furthermore, the molecules can be retained inside the cells without noticeable leakage to the outside. Therefore, these ATE-based compounds can be used as selective and cell-compatible fluroescent bioprobes for long-term live cell tracking and imaging.