Abstract: Systems and methods permit remote control of the operation of an endoscope. The system includes a control housing that removably attaches to an endoscope, with the housing including actuators and manipulators that engage with a control device of the endoscope in order to operate the control device. The system includes an axial roller that may be used to control the depth of the endoscope shaft within a patient's body.

Abstract: Non-linear spectroscopic devices, systems, and methods for probing molecules. A non-linear spectroscopic method for probing molecules can include providing a plurality of molecules in an aqueous solution, the providing being effective for permitting the molecules to be free in said aqueous solution and without the molecules being bound to another material such that second harmonic or sum frequency coherent light would result from the illumination of the molecules changes in their conformation. The method can also include probing the molecules by directing light at one or more selected frequencies to generate second harmonic or sum frequency incoherent light resulting from predefined interactions between the first and second molecules and capturing the incoherent light and detecting the same.

Abstract: Methods and compositions useful for the treatment and/or prevention of muscle weakness in cancer patients. In certain embodiments, the methods of the present invention include administering to a cancer patient a therapeutically or prophylactically effective amount of one or more inhibitors of TGFbeta signaling.

Abstract: Systems and methods for heating a material wherein the system includes an electrical contact adapted to receive current and a glassy carbon heater in electrical communication with the electrical contact. In one embodiment, the sample is thermally evaporated. In one embodiment, a holding element adapted to hold the material, located in such proximity to the glassy carbon heater so as to receive heat generated by the glassy carbon heater, is included.

Abstract: Methods and compositions useful for the treatment and/or prevention of muscle weakness in cancer patients. In certain embodiments, the methods of the present invention include administering to a cancer patient a therapeutically or prophylactically effective amount of one or more inhibitors of TGFbeta signaling in combination with one or more benzothiazepine derivatives.

Abstract: An apparatus or method can include forming a graphene layer including a working surface, forming a polyvinyl alcohol (PVA) layer upon the working surface of the graphene layer, and forming a dielectric layer upon the PVA layer. In an example, the PVA layer can be activated and the dielectric layer can be deposited on an activated portion of the PVA layer. In an example, an electronic device can include such apparatus, such as included as a portion of graphene field-effect transistor (GFET), or one or more other devices.

Abstract: Compactly-integrated electronic structures and associated systems and methods are provided. Certain embodiments relate to the ability to integrate nanowire-based detectors with optical components.

Abstract: Spherical gradient index (GRIN) lens that can achieve perfect imaging and maximum concentration is provided. Various refractive index profiles for the GRIN lens allow the lens to be manufactured by the currently available materials and fabrication techniques. Systems and methods for photovoltaic solar concentration are provided in which the optic tracks the sun and the photovoltaic cell remains stationary. The optic of such systems and methods can include perfect imaging spherical GRIN lens to provide high flux concentration.

Abstract: It has been discovered that that certain growth factors can delay the ossification of a tissue site, such as a cranial suture, via the promotion of fibroblast differentiation and/or inhibition of osteoblast differentiation. Provided herein are methods for treating bone formation conditions or disorders, such as synostotic conditions, or ectopic mineralization conditions, via administration of compositions comprising connective tissue growth factor (CTGF), and optionally other growth factors or fibroblast or progenitor cells, to a tissue site of a subject in need thereof.

Abstract: The present invention relates to compositions and methods for the inhibition of apoptosis associated with ischemic injury in the central nervous system. In addition, the present invention relates to compositions and methods useful for extending the therapeutic window associated with ischemic injury.

Abstract: Systems and methods for applying a graphene nanocrystalline layer on a substrate in a vacuum chamber including positioning the substrate in the vacuum chamber, evacuating the vacuum chamber to a pressure of less than 10?3 torr, and applying an electrical current to the glassy carbon filament to generate graphene carbon, in which the substrate is positioned in a location to receive at least a portion of the graphene carbon upon the application of current.

Abstract: Methods for inhibition of hairless protein mRNA using RNA interference is described, in particular methods for hair removal. Also described are nucleic acid constructs for RNAi-mediated inhibition of hairless protein mRNA and compositions including such constructs.

Abstract: Systems and methods for matching a characteristic of multiple sectors of a moving tissue to verify an overlap thereof are disclosed herein. In an exemplary method, tissue data for at least a first sector and a second sector of a moving tissue is acquired. A characteristic of at least a portion of the first and second sectors is estimated from the acquired tissue data, and the estimated characteristics are matched to verify whether a portion of the first sector overlaps with a portion of the second sector. Estimating can include estimating a displacement such as an axial displacement and/or lateral displacements. Estimating can further include estimating a strain, a velocity, a strain rate and/or a stiffness or equivalent.

Abstract: Systems and methods for correlating and distributing intrusion alert information among collaborating computer systems are provided. These systems and methods provide an alert correlator and an alert distributor that enable early signs of an attack to be detected and rapidly disseminated to collaborating systems. The alert correlator utilizes data structures to correlate alert detections and provide a mechanism through which threat information can be revealed to other collaborating systems. The alert distributor uses an efficient technique to group collaborating systems and then pass data between certain members of those groups according to a schedule. In this way data can be routinely distributed, without generating excess traffic loads.

Abstract: The present disclosure shows new mechanisms fir sampling an input signal. In particular, some embodiments of the present disclosure include a new type of a level-crossing sampling mechanism called a derivative level-crossing sampling (D-LCS). At a high level, D-LCS involves quantizing the derivative of an input signal when the derivative of the input signal crosses one of the quantization thresholds. For certain class of signals, the derivative of the input signal can vary at a slower speed compared to the amplitude of the input signal. Therefore, by sampling the derivative of the input signal, instead of the input signal itself, the number of samples per unit time can be reduced.

Abstract: A system and methods of detecting an occurrence of a violation of an email security policy of a computer system. A model relating to the transmission of prior emails through the computer system is defined which is derived from statistics relating to the prior emails. For selected emails to be analyzed, statistics concerning the selected email are gathered. Such statistics may refer to the behavior or other features of the selected emails, attachments to emails, or email accounts. The determination of whether a violation of an email security policy has occurred is performed by applying the model of prior email transmission to the statistics relating to the selected email. The model may be statistical or probabilistic. A model of prior email transmission may include grouping email recipients into cliques. A determination of a violation of a security policy may occur if email recipients for a particular email are in more than one clique.

Abstract: In one embodiment, the present invention is directed to methods for diagnosis of urinary tract obstruction (UTO), and to methods for distinguishing between unilateral and bilateral UTO. In some aspects, the diagnostic methods of the invention are based on determining whether a bodily fluid sample, such as a urine sample, contains an amount of NGAL protein that exceeds or is less than a certain threshold level, or that falls within a certain range. The present invention also provides diagnostic kits for the diagnosis of UTO and for distinguishing between unilateral and bilateral UTO.

Abstract: A library includes H unique nucleotide sequences involving every position along I continuous positions in a molecule. A method to prepare the library includes obtaining a microarray with a bound probe of up to J nucleotides, J=I+L, for H different probes. The first L nucleotides are reverse complementary to a constant portion in the library at a 5? end. The remaining nucleotides of different probes are reverse complementary to corresponding different library members. A primer equal to the constant portion in the library is introduced. The primer is extended along the probe as a library strand using DNA polymerase. A first strand of a double stranded linker is ligated with a phosphate group to the library strand. The first strand has a sequence that matches a constant portion in the library at a 3? end. The library strand is stripped from the probe and from a different second strand of the linker.

Abstract: Methods, systems, and media for identifying cover songs using two-dimensional Fourier transform magnitudes are provided. In some embodiments, methods for identifying a cover song from a query song are provided, the methods comprising: identifying a query song vector for the query song, wherein the query song vector is indicative of a two-dimensional Fourier transform based on the query song; identifying a plurality of reference song vectors that each correspond to one of a plurality of reference songs, wherein each of the plurality of reference song vectors is indicative of a two-dimensional Fourier transform created based on the corresponding reference song; determining a distance between the query song vector and each of the plurality of reference song vectors; generating an indication that a reference song corresponding to a reference song vector with a shortest distance to the query song vector is a similar song to the query song.

Abstract: Disclosed herein are methods and compositions for genome editing of the malarial parasite Plasmodium, and for the use of the edited Plasmodium in the development of vaccines and therapeutics.