Abstract: Methods and systems for predicting links in a network, such as a social network, are disclosed. The existing network structure can be used to optimize link prediction. The methods and systems can learn a distance metric and/or a degree preference function that are structure preserving to predict links for new/existing nodes based on node properties.

Abstract: The disclosed subject matter relates to a force-clamp spectrometer that enables operation in constant force mode and allows for automated data acquisition and analysis, using feedback electronics and software. The disclosed subject matter also relates to methods of using the force-clamp spectrometer for the measurement of the dynamics of chemical reactions. The methods may include, but are not limited to, the measurement of the dynamics of substrate folding and unfolding, as well as bond cleavage and bond formation.

Abstract: Embodiments of the invention disclosed herein generally relate to anti-cocaine therapeutics. Specifically, some embodiments of the invention relate to highly efficient, thermostable, and long-lasting cocaine esterase (CocE) mutants that can protect against the toxic and reinforcing effects of cocaine in subjects. Provided herein are mutant CocE polypeptides displaying thermostable esterase activity. Also provided are methods of treating cocaine-induced conditions in a subject in need via administration of mutant CocE as well as methods for high-throughput screening of candidate esterase polypeptides.

Abstract: Methods of determining the onset or susceptibility of an immunological disease are provided herein. Also provided are immunoassay techniques for carrying out such methods.

Abstract: The invention provides for methods and systems for engineering target proteins, based on protein sequence characteristics that influence the likelihood of obtaining a crystal suitable for X-ray structure solution, to improve protein crystallization, as well as related material.

Abstract: A method for organizing and displaying EEG data obtained from C EEG channels on a computer system in a user-friendly manner includes placing the C EEG channels into a schematic placement diagram dividing the C EEG channels, using a processor, into G channel groups for each of the G channel groups, combining any of the C EEG channels in such G channel group, using a processor, into a single trace, and for each of the G channel groups, displaying the single trace. A system for organizing and displaying EEG data is also provided.

Abstract: Asynchronous digital circuits are described, including arbitration and routing primitives for asynchronous and mixed-timing networks. An asynchronous arbitration primitive has two data inputs and one data output. A mutual exclusion element is used to select the first-arriving data request from one of the two inputs to the output. A asynchronous routing primitive has one data input and two data outputs. The incoming data is routed to one of the two outputs based on a routing bit accompanying the data. The primitives use handshaking with request and acknowledge signals to ensure that data is passed when neighboring circuits are ready to receive or send data.

Abstract: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3?-position of the deoxyribose.

Abstract: A method for distributing a quantum key is provided, including sending a first photon to a first receiver; sending a second photon to a second receiver, the first and second photons being a pair of time-energy entangled photons; and providing a coding scheme comprising a plurality of time bins and a plurality of frequency bins, wherein a combination of a time bin and a frequency bin corresponds to a character.

Abstract: Methods, systems, and media for identifying similar songs using jumpcodes are provided. In some embodiments, methods for a cover song from a query song are provided, the methods comprising: identifying a query song jumpcode for the query song, wherein the query song jumpcode is indicative of changes in prominent pitch over a portion of the query song; identifying a plurality of reference song jumpcodes for a reference song, wherein each of the reference song jumpcodes is indicative of changes in prominent pitch over a portion of the reference song; determining if the query song jumpcode matches any of the plurality of reference song jumpcodes; and upon determining that the query song jumpcode matches at least one of the plurality of reference song jumpcodes, generating an indication that the reference song is a cover song of the query song.

Abstract: Circuits that operate with power supplies of less than 1 Volt are presented. More particularly, circuits that operate with supply voltages near or lower than the threshold voltage of the transistors in those circuits are presented. Various circuits and embodiments such as operational transconductance amplifiers, biasing circuits, integrators, continuous-time sigma delta modulators, track-and-bold circuits, and others are presented. The techniques and circuits can be used in a wide range of applications and various transistors from metal-oxide-semiconductor to bipolar junction transistors may implement the techniques presented herein.

Abstract: A device for self-administration of massage, trigger point therapy and/or myofascial release, and methods for same.

Abstract: A capital asset planning system for selecting assets for improvement within an infrastructure that includes one or more data sources descriptive of the infrastructure, one or more databases, coupled to the one or more data sources, to compile the one or more data sources, one or more processors, each coupled to and having respective communication interfaces to receive data from the one or more databases. The processor includes a predictor to generate a first metric of estimated infrastructure effectiveness based, at least in part, on a current status of the infrastructure, a second metric of estimated infrastructure effectiveness based, at least in part, on a user-selected, proposed changed configuration of the infrastructure, and a net metric of infrastructure effectiveness based, at least in part, on said first metric and said second metric.

Abstract: An electrolytic cell system to convert carbon dioxide to a hydrocarbon that includes a first electrode including a substrate having a metal porous dendritic structure applied thereon; a second electrode, and an electrical input adapted for coupling to a source of electricity, for applying a voltage across the first electrode and the second electrode.

Abstract: The present invention relates to biomarkers which constitute a metastasis associated fibroblast (“MAF”) signature and their use in diagnosing and staging a variety of cancers. It is based, at least in part, on the discovery that identifying the differential expression of certain genes indicates a diagnosis and/or stage of a variety of cancers with a high degree of specificity. In particular, the presence of the signature implies that the cancer has already become invasive. Accordingly, in various embodiments, the present invention provides for methods of diagnosis, diagnostic kits, as well as methods of treatment that include an assessment of biomarker status in a subject. Further, because the differential expression of certain genes can function as marker for the acquisition of metastatic potential, such expression profiles can be used to predict the appropriateness of certain therapeutic interventions, such as the appropriateness of neoadjuvant therapies.