Patents by Inventor Thea Van Der Wijk
Thea Van Der Wijk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11402374Abstract: The invention relates to a method for the detection of target components that comprise label particles, for example magnetic particles (1). The method includes (a) collecting the target components at a binding surface (12, 112, 512) of a carrier (11, 111, 211, 311, 411, 511); (b) directing an input light beam (L1, L1a, L1b) into the carrier such that it is totally internally reflected in an investigation region (13, 313a, 313b) at the binding surface (12, 112, 512); and (c) determining the amount of light of an output light beam (L2, L2a, L2b) that comprises at least some of the totally internally reflected light. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the output light beam (L2, L2a, L2b).Type: GrantFiled: May 8, 2015Date of Patent: August 2, 2022Assignee: Siemens Healthineers Nederland B.V.Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina De Theije, Thea van der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Patent number: 11243199Abstract: The invention relates to a carrier with a binding surface at which target components that comprise label particles, for example magnetic particles, can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles at the binding surface and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface from the amount of light in the output light beam (L2, L2a, L2b).Type: GrantFiled: April 15, 2015Date of Patent: February 8, 2022Assignee: Siemens Healthineers Nederland B.V.Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina De Theije e/v Wijgergangs, Thea van der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Publication number: 20210341554Abstract: The present invention relates to methods and (bio)sensor systems. Herein, magnetic fields are applied in order to transport magnetic particles laterally over a sensor surface with analyte specific probes. The methods of the invention allow the specific binding of magnetic particles to the sensor surface, while aspecific and unbound particles are removed.Type: ApplicationFiled: July 16, 2021Publication date: November 4, 2021Applicant: SIEMENS HEALTHINEERS NEDERLAND B.V.Inventors: Thea Van Der Wijk, Menno Willem Jose Prins, Richard Joseph Marinus Schroeders
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Patent number: 10488408Abstract: The application relates to a method for detecting a target in a sample suspected of containing the target. The method comprises contacting the sample and a first binding molecule attached to a magnetic particle with a second binding molecule attached to a solid support. The first binding molecule is capable of binding to the second binding molecule, and the target is capable of interfering with this binding. Magnetic force is applied to bring the magnetic particle into close proximity with the solid support. The number of magnetic particles bound to the solid support is detected.Type: GrantFiled: April 27, 2007Date of Patent: November 26, 2019Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Thea Van Der Wijk, Eduard Gerard Marie Pelssers, Jessica Amadio
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Patent number: 10092903Abstract: The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.Type: GrantFiled: December 16, 2008Date of Patent: October 9, 2018Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Menno Willem Jose Prins, Joost Hubert Maas, Albert Hendrik Jan Immink, Dirkjan Bernhard Van Dam, Maatje Koets, Michel J. M. Bruyninckx, Thea Van Der Wijk, Marius Iosif Boamfa, Remco Den Dulk
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Patent number: 9778254Abstract: A system and method wherein components of a reagent such as labeled antibodies are separated from a biologically active sensor surface by depositing the reagent on a carrier surface distinct from a sensor surface in a detection region. The present device provides a short, well-defined and controlled, pre-incubation time between the particles of interest in the sample fluid and the reagent, thereby increasing the reproducibility by providing all components in one detection region such as a detection chamber.Type: GrantFiled: July 18, 2008Date of Patent: October 3, 2017Assignees: KONINKLIJKE PHILIPS N.V., CONCATENO UK LIMITEDInventors: Femke Karina De Theije, Thea Van Der Wijk, Albert Hendrik Jan Immink, Eduard Gerard Marie Pelssers, Wilhelmina Maria Hardeman, Sandra Marlin, Gordon Thomas Jowett
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Patent number: 9658219Abstract: A microelectronic sensor device for the detection of target components with label or magnetic particles includes a carrier with a binding surface at which target components can collect and optionally bind to specific capture elements. An input light beam is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam is detected by a light detector. Evanescent light generated during the total internal reflection is affected by target components and/or label particles at the binding surface and will be missing in the output light beam. This is used to determine the amount of target components at the binding surface from the amount of light in the output light beam. A magnetic field generator is optionally used to generate a magnetic field at the binding surface by which magnetic label particles can be manipulated, such as attracted or repelled.Type: GrantFiled: December 10, 2007Date of Patent: May 23, 2017Assignee: Koninklijke Philips N.V.Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina De Theije, Thea Van Der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Patent number: 9128084Abstract: A detection system (100) and a sensor chip (1) for detecting target molecules, and thus corresponding analytes in a sample is described. Typically the detection system (100) includes a sensor chip (1). The sensor chip (1) comprises on its detection surface (33) a dissolvable reagent layer (5). When the dissolvable reagent layer (5) is in contact with sample fluid, free reagent is generated, assisting in the interaction between a label and target molecules, thus allowing for label based detection. The sample thereby is exposed to mobile reagents in a burst. The reagent layer may contain an enzyme allowing enzymatic assays.Type: GrantFiled: October 10, 2007Date of Patent: September 8, 2015Assignee: Koninklijke Philips N.V.Inventors: Menno Willem Jose Prins, Thea Van Der Wijk
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Publication number: 20150241416Abstract: The invention relates to a method for the detection of target components that comprise label particles, for example magnetic particles (1). The method includes (a) collecting the target components at a binding surface (12, 112, 512) of a carrier (11, 111, 211, 311, 411, 511); (b) directing an input light beam (L1, L1a, L1b) into the carrier such that it is totally internally reflected in an investigation region (13, 313a, 313b) at the binding surface (12, 112, 512); and (c) determining the amount of light of an output light beam (L2, L2a, L2b) that comprises at least some of the totally internally reflected light. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the output light beam (L2, L2a, L2b).Type: ApplicationFiled: May 8, 2015Publication date: August 27, 2015Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina DE THEIJE e/v WIJGERGANGS, Thea van der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Publication number: 20150226733Abstract: The invention relates to a carrier with a binding surface at which target components that comprise label particles, for example magnetic particles, can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface. The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector. Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles at the binding surface and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface from the amount of light in the output light beam (L2, L2a, L2b).Type: ApplicationFiled: April 15, 2015Publication date: August 13, 2015Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina DE THEIJE e/v WIJGERGANGS, Thea van der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Publication number: 20110050215Abstract: A magnetic system for biosensors or a biosystem, wherein magnetic particles that interact with molecules are brought into a magnetic field, in order to be influenced via magnetic attraction or repulsion forces. The external magnetic field is varied by mechanically moving the magnetic poles of at least one magnetic relative to the sensor or at least its surface to allow the magnetic force to be switched between effective attraction towards the sensor surface and effective repulsion away from the sensor surface.Type: ApplicationFiled: December 7, 2007Publication date: March 3, 2011Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Josephus Arnoldus Henricus Maria Kahlmann, Albert Hendrik Jan Immink, Jeroen Hans Jeroen, Thea Van Der Wijk, Femke Karina De Theije
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Publication number: 20100297780Abstract: A system and method is described wherein components of the reagent (4), e.g. labelled antibodies, are separated from the biologically active sensor surface (5) by depositing the reagent (4) on a carrier surface (3) distinct from the sensor surface (5) in the detection region (2), e.g. detection chamber. In this way, a high assay reproducibility is obtained. By allowing a short, well-defined and controlled, pre-incubation time between the particles of interest, e.g. drugs, in the sample fluid (20) and the reagent (4), the reproducibility will be increased, whereas the speed of the assay is guaranteed by having all components in one detection region (2), e.g. detection chamber.Type: ApplicationFiled: July 18, 2008Publication date: November 25, 2010Applicant: Koninklijke Philips Electronics N.V.Inventors: Femke Karina De Theije, Thea Van Der Wijk, Albert Hendrik Jan Immink, Eduard Gerard Marie Pelssers, Wilhelmina Maria Hardeman, Sandra Marlin, Gordon Thomas Jowett
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Publication number: 20100273142Abstract: The present invention discloses microfluidic devices with a valve-like structure (3), through which magnetic particles can be transported with minimal transport of fluids. This allows sequential processing of the magnetic particles.Type: ApplicationFiled: December 16, 2008Publication date: October 28, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Menno Willem Jose Prins, Joost Hubert Maas, Albert Hendrik Jan Immink, Dirkjan Bernhard Van Dam, Maatje Koets, Michel J.M. Bruyninckx, Thea Van Der Wijk, Marius losif Boamfa, Remco Den Dulk
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Publication number: 20100253323Abstract: Detecting magnetized or magnetizable target components in a fluid containing the magnetized or magnetizable target components amongst other magnetized or magnetizable components, uses a magnetic field generator (M1, 28) to attract the magnetized or magnetizable components towards a binding surface. A magnetic field controller (C1) applies the magnetic field to concentrate the magnetized or magnetizable components in columns on the binding surface, subsequently reduces the magnetic field to enable the columns to collapse, to allow more components to reach the binding surface, and reapplies the magnetic field so as to cause other components to be pulled off the binding surface to reform columns based on the bound target components. A surface sensitive sensor (S1, 26, 29) detects the bound magnetized or magnetizable target components.Type: ApplicationFiled: December 4, 2008Publication date: October 7, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Femke Karina De Theije, Dominique Maria Bruls, Thea Van Der Wijk, Coen Adrianus Verschuren, Albert Hendrik Jan Immink
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Publication number: 20100092996Abstract: The invention relates to a microelectronic sensor device for the detection of target components that comprise label particles, for example magnetic particles (1). The sensor device comprises a carrier (11) with a binding surface (12) at which target components can collect and optionally bind to specific capture elements. An input light beam (L1) is transmitted into the carrier and totally internally reflected at the binding surface (12). The amount of light in the output light beam (L2) and optionally also of fluorescence light emitted by target components at the binding surface is then detected by a light detector (31). Evanescent light generated during the total internal reflection is affected (absorbed, scattered) by target components and/or label particles (1) at the binding surface (12) and will therefore be missing in the output light beam (L2). This can be used to determine the amount of target components at the binding surface (12) from the amount of light in the output light beam (L2, L2a, L2b).Type: ApplicationFiled: December 10, 2007Publication date: April 15, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Coen Adrianus Verschuren, Dominique Maria Bruls, Albert Hendrik Jan Immink, Femke Karina De Theije, Thea Van Der Wijk, Alexander Marc Van Der Lee, Johannes Joseph Hubertina Barbara Schleipen
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Publication number: 20100009456Abstract: A detection system (100) and a sensor chip (1) for detecting target molecules, and thus corresponding analytes in a sample is described. Typically the detection system (100) includes a sensor chip (1). The sensor chip (1) comprises on its detection surface (33) a dissolvable reagent layer (5). When the dissolvable reagent layer (5) is in contact with sample fluid, free reagent is generated, assisting in the interaction between a label and target molecules, thus allowing for label based detection. The sample thereby is exposed to mobile reagents in a burst. The reagent layer may contain an enzyme allowing enzymatic assays.Type: ApplicationFiled: October 10, 2007Publication date: January 14, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Menno Willem Jose Prins, Thea Van Der Wijk
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Publication number: 20090170212Abstract: The present invention relates to methods and (bio)sensor systems. Herein, magnetic fields are applied in order to transport magnetic particles laterally over a sensor surface with analyte specific probes. The methods of the invention allow the specific binding of magnetic particles to the sensor surface, while aspecific and unbound particles are removed.Type: ApplicationFiled: May 7, 2007Publication date: July 2, 2009Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Thea Van Der Wijk, Menno Willem Jose Prins, Richard Joseph Marinus Schroeders
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Publication number: 20090117670Abstract: The application relates to a method for detecting a target in a sample suspected of containing the target. The method comprises contacting the sample and a first binding molecule attached to a magnetic particle with a second binding molecule attached to a solid support. The first binding molecule is capable of binding to the second binding molecule, and the target is capable of interfering with this binding. Magnetic force is applied to bring the magnetic particle into close proximity with the solid support. The number of magnetic particles bound to the solid support is detected.Type: ApplicationFiled: April 27, 2007Publication date: May 7, 2009Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Thea Van Der Wijk, Eduard Gerard Marie Pelssers, Jessica Amadio