Abstract: The present invention relates to an infusion set (10) that provides for continuous air free delivery of liquid to patients undergoing infusion procedures. In particular, the invention provides for an infusion set (10) that prevents air entering the infusion tubing (40) through the drip chamber (20) by using a hydrophilic membrane (21) having a defined wetting time and a defined mean pore size that will provide a defined bubble pressure point under gravitational pull to permit continuous air free infusion liquid flow there-through. The invention further provides for a clip (50) that once closed, no air bubble is able to pass through the hydrophilic membrane (21) due to the adjustment of the roller clamp (60) along the infusion tubing (40) thereby ensuring safe replacement of the infusion bottle during multiple infusion procedures, thus preventing the occurrence of air embolism in patients especially when the drip chamber (20) is empty.