Abstract: Peptides that home, migrate to, distribute to, accumulate in, are directed to, and/or bind to tumors, cancerous tissues and cells thereof are disclosed. Pharmaceutical compositions and uses for peptides, peptide-active agent complexes comprising such peptides, or peptide-detectable agent complexes comprising such peptides are additionally disclosed. Such compositions can be formulated for targeted or untargeted delivery of a drug to a target region, tissue, structure or cell. Targeted compositions of the disclosure can deliver peptide, peptide-active agent complexes, or peptide-detectable agent complexes to target regions, tissues, structures or cells targeted by the peptide.

Abstract: Peptides that home, distribute to, target, are directed to, or accumulate in tumors, cancers, or diseased cells are disclosed. Peptides that cross the blood brain barrier and home, distribute to, target, are directed to, or accumulate in the brain and in a specific region of the brain are also disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are additionally disclosed. Such compositions can be formulated for targeted or untargeted delivery of a drug to a target region, tissue, structure or cell. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures or cells targeted by the peptide.