Patents by Inventor Theodoor Hagg

Theodoor Hagg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Treating Ischemic Disease by Administering an ATR Kinase Inhibitor
    Publication number: 20240009187
    Abstract: A method of treating a subject suffering from an ischemic disease associated with Ca2+ overload is provided, the method including administering to the subject an effective amount of an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. Also provided is a method of treating a subject suffering from acute ischemic stroke, the method including administering to the subject an effective amount of the ATR kinase inhibitor berzosertib.
    Type: Application
    Filed: September 22, 2023
    Publication date: January 11, 2024
    Applicant: East Tennessee State University Research Foundation
    Inventors: Theodoor Hagg, Yue Zou
  • Methods of treating ischemic disease by administering an ATR kinase inhibitor
    Patent number: 11801246
    Abstract: A method of treating a subject suffering from an ischemic disease associated with Ca2+ overload is provided, the method including administering to the subject an effective amount of an inhibitor of Ataxia telangiectasia and Rad3-related (ATR) kinase. Also provided is a method of treating a subject suffering from acute ischemic stroke, the method including administering to the subject an effective amount of the ATR kinase inhibitor berzosertib.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: October 31, 2023
    Assignee: EAST TENNESSEE STATE UNIVERSITY RESEARCH FOUNDATIO
    Inventors: Theodoor Hagg, Yue Zou
  • Methods of Treating Ischemic Disease by Administering an ATR Kinase Inhibitor
    Publication number: 20200147077
    Abstract: A method of treating a subject suffering from an ischemic disease associated with Ca2+ overload is provided, the method including administering to the subject an effective amount of an inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. Also provided is a method of treating a subject suffering from acute ischemic stroke, the method including administering to the subject an effective amount of the ATR kinase inhibitor berzosertib.
    Type: Application
    Filed: November 8, 2019
    Publication date: May 14, 2020
    Inventors: Theodoor Hagg, Yue Zou
  • NEUROPROTECTIVE INTEGRIN-BINDING PEPTIDE AND ANGIOPOIETIN-1 TREATMENTS
    Publication number: 20090247466
    Abstract: The present invention provides therapeutic compositions, kits and methods for treating nervous system injury in a mammal. Certain methods include administering to a mammal in need of such therapy an effective amount of angiopoietin-1 (Ang-1), or a functional analog thereof. Certain methods include administering a peptide having 4 to 20 amino acids that comprises an YVRL (SEQ ID NO:1) motif that may have activity at the ?v?3 or ?5?1 integrin receptor, such as C-16, or a compound that is an agonist at the ?v?3 and/or ?5?1 integrin receptor, which administration may be in combination with administration of Ang-1, or a functional analog thereof.
    Type: Application
    Filed: March 10, 2009
    Publication date: October 1, 2009
    Applicant: University of Louisville Research Foundation
    Inventors: Theodoor Hagg, Scott R. Whittemore
  • NEUROPROTECTIVE TREATMENTS
    Publication number: 20090023700
    Abstract: The present invention provides a therapeutic method for treating traumatic neural injury or a degenerative disorder in a mammal by administering a neuroprotective compound, wherein the neuroprotective compound is a peroxovanadium compound, a peroxovandium derivative, or a compound with inhibitory activity of protein tyrosine phosphatases.
    Type: Application
    Filed: July 18, 2008
    Publication date: January 22, 2009
    Applicant: University of Louisville Research Foundation
    Inventor: Theodoor Hagg