Patents by Inventor Theodor Denzel

Theodor Denzel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20070238866
    Abstract: Method for the production of C-aryl glucoside SGLT2 inhibitors useful for the treatment of diabetes and related diseases. and intermediates thereof. The C-aryl glucosides may be complexed with amino acid complex forming reagents.
    Type: Application
    Filed: June 19, 2007
    Publication date: October 11, 2007
    Inventors: Prashant Deshpande, Bruce Ellsworth, Janak Singh, Theodor Denzel, Chiajen Lai, Gerard Crispino, Michael Randazzo, Jack Gougoutas
  • Publication number: 20040059123
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
    Type: Application
    Filed: August 12, 2003
    Publication date: March 25, 2004
    Inventors: Richard P. Polniaszek, Xuebao Wang, John K. Thottathil, Theodor Denzel
  • Patent number: 6639082
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: October 28, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Richard P. Polniaszek, Xuebao Wang, John K. Thottathil, Theodor Denzel
  • Publication number: 20020132838
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
    Type: Application
    Filed: September 28, 2001
    Publication date: September 19, 2002
    Inventors: Richard P. Polniaszek, Xuebao Wang, John K. Thottathil, Theodor Denzel
  • Patent number: 6340752
    Abstract: Acylmercaptoalkanoylamino lactam esters or acids are converted to the corresponding mercaptoalkanoylamino lactam ester or acid under basic conditions by including an agent which minimizes the amount of disulfides. Suitable agents are bismercaptans, phosphine or phosphite reducing agents, zinc metal powder, and sodium hydrosulfite. Such agents are also employed in the recrystallization and reprocessing of the mercaptoalkanoylamino lactam acids.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: January 22, 2002
    Assignee: Bristol-Myers Squibb Co.
    Inventors: David R. Kronenthal, Theodor Denzel, Bang-Chi Chen, James H. Simpson, Rajendra P. Deshpande
  • Patent number: 5194604
    Abstract: Disclosed herein are processes for preparing a compound of the formula ##STR1## in which a novel compound of the formula ##STR2## is reacted with a beta lactam of the formula ##STR3## by treatment with a base, wherein the symbols are as defined in the specification.
    Type: Grant
    Filed: June 29, 1990
    Date of Patent: March 16, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Christopher M. Cimarusti, Janak Singh, Richard H. Mueller
  • Patent number: 4734496
    Abstract: .beta.-Lactams having a sulfonic acid salt substituent in the 1-position, an acylamino substituent in the 3-position and an --NR.sub.2 R.sub.3 substituent in the 4-position wherein R.sub.2 and R.sub.3 are the same or different and each is ##STR1## or R.sub.2 and R.sub.3 together with the nitrogen atom to which they are attached are ##STR2## R.sub.4 is alkyl, aryl or arylalkyl; and R.sub.5 and R.sub.6 are the same or different and each is hydrogen, halogen, alkyl, alkoxy, alkylthio, alkoxycarbonyl, carboxyl or a carboxyl salt; have antibacterial activity.
    Type: Grant
    Filed: May 29, 1981
    Date of Patent: March 29, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Uwe D. Treuner, Theodor Denzel, Hermann Breuer
  • Patent number: 4670553
    Abstract: Antibacterial activity is exhibited by compounds having the formula ##STR1## and salts thereof, wherein R.sub.1 is acyl;R.sub.2 is hydrogen or methoxy;R.sub.3 and R.sub.4 are the same or different and each is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl or a 5,6 or 7-membered heterocycle or one of R.sub.3 and R.sub.4 is hydrogen and the other is azido, halomethyl, dihalomethyl, trihalomethyl, alkoxycarbonyl, 2-phenylethenyl, 2-phenylethynyl, carboxyl, ##STR2## X.sub.1 is azido, amino, hydroxy, alkanoylamino, alkylsulfonyloxy, arylsulfonyloxy, aryl, cyano, --S--X.sub.2 or --O--X.sub.2 ;X.sub.2 is alkyl, substituted alkyl, aryl, arylalkyl, alkanoyl, substituted alkanoyl, arylcarbonyl or heteroarylcarbonyl;one of X.sub.3 and X.sub.4 is hydrogen and the other is hydrogen or alkyl, or X.sub.3 and X.sub.4 when taken together with the carbon atom to which they are attached from a cycloalkyl group;X.sub.
    Type: Grant
    Filed: November 26, 1982
    Date of Patent: June 2, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Theodor Denzel
  • Patent number: 4587047
    Abstract: Antibacterial activity is exhibited by .beta.-lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position wherein Z is oxygen or sulfur, and R is alkyl, alkenyl, alkynyl, substituted alkyl, phenyl, substituted phenyl, a 5,6 or 7-membered heterocycle (R.sub.c), phenylalkyl, (substituted phenyl)alkyl, R.sub.c -alkyl or --NR.sub.a R.sub.b wherein R.sub.a and R.sub.b are the same or different and each is hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, phenylalkyl, or (substituted phenyl)alkyl or one of R.sub.a and R.sub.b is hydrogen, alkyl, phenyl, substituted phenyl, phenylalkyl or (substituted phenyl)alkyl and the other is amino, alkanoylamino, arylcarbonylamino, alkoxycarbonylamino, alkylsulfonylamino, alkylamino, dialkylamino, phenylamino, (substituted phenyl)amino, hydroxy, cyano, alkoxy, phenyloxy, (substituted phenyl)oxy, phenylalkoxy, (substituted phenyl)alkoxy, R.sub.c, R.sub.c -alkyl, R.sub.
    Type: Grant
    Filed: April 1, 1982
    Date of Patent: May 6, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, William A. Slusarchyk, Theodor Denzel, Uwe D. Treuner
  • Patent number: 4501743
    Abstract: Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, ##STR2## X is hydrogen, ##STR3## R.sub.4 is hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl, ##STR4## --(CH.sub.2).sub.n --N--(lower alkyl).sub.2 ; R.sub.6 is hydrogen, sodium, or potassium; n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-bacterial agents.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: February 26, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Uwe D. Treuner, Theodor Denzel
  • Patent number: 4499016
    Abstract: Antibacterial activity is exhibited by .beta.-lactams having an --SO.sub.2 --NH--C--R substituent in the 1-position and an acylamino substituent in the 3-position wherein R is alkyl, phenyl, substituted phenyl, phenylalkyl, (substituted phenyl)alkyl, alkoxy, phenyloxy, (substituted phenyl)oxy, phenylalkoxy, or (substituted phenyl)alkoxy.
    Type: Grant
    Filed: August 6, 1981
    Date of Patent: February 12, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Theodor Denzel, Uwe D. Treuner
  • Patent number: 4461767
    Abstract: Cephalosporins of the formula ##STR1## wherein R is hydrogen, sodium, potassium or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 is hydrogen, ##STR2## R.sub.4 is hydrogen or lower alkyl; R.sub.5 is hydrogen, lower alkyl, ##STR3## or --(CH.sub.2).sub.n --N--(lower alkyl).sub.2 ; R.sub.6 is hydrogen, sodium, or potassium; n is an integer from 1 to 4; are disclosed. These compounds are useful as anti-bacterial agents.
    Type: Grant
    Filed: June 6, 1979
    Date of Patent: July 24, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Hermann Breuer, Uwe D. Treuner, Theodor Denzel
  • Patent number: 4271157
    Abstract: A compound of the formula ##STR1## wherein R is hydrogen, alkali metal, ##STR2## R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen or methyl;R.sub.3 is hydrogen or methyl;R.sub.4 is hydrogen, --OCONH.sub.2, ##STR3## R.sub.5 is hydrogen or methyl;R.sub.6 is hydrogen, methyl, benzyl or acetyl;R.sub.7 is hydrogen or lower alkyl;R.sub.8 is hydrogen or --CONH.sub.2 ;R.sub.9 is hydrogen, lower alkyl, ##STR4## or --(CH.sub.2).sub.p --N--(lower alkyl).sub.2 ; R.sub.10 is hydrogen or lower alkyl;R.sub.11 is hydrogen, sodium or potassium;n is 1, 2, 3 or 4;m is 0, 1 or 2;p is 1, 2, 3 or 4.
    Type: Grant
    Filed: February 28, 1980
    Date of Patent: June 2, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hermann Breuer
  • Patent number: 4269836
    Abstract: New 4H-pyrazolo[4',3':5,6]pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-5(8H)on e and new derivatives thereof have the general formula ##STR1## The compounds are useful as anti-inflammatory agents and central nervous system depressants.
    Type: Grant
    Filed: July 13, 1976
    Date of Patent: May 26, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hans Hoehn
  • Patent number: 4252802
    Abstract: A compound of the formula ##STR1## wherein R is hydrogen, alkali metal, ##STR2## or ##STR3## R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen or methyl;R.sub.3 is hydrogen, lower alkyl or lower alkylphenyl;R.sub.4 is hydrogen, --OCONH.sub.2, ##STR4## R.sub.7 is hydrogen or lower alkyl; R.sub.8 is hydrogen or --CONH.sub.2 ;R.sub.9 is hydrogen, lower alkyl, ##STR5## or --(CH.sub.2).sub.p --N--(lower alkyl).sub.2 ; R.sub.10 is hydrogen or lower alkyl;R.sub.11 is hydrogen, sodium or potassium;n is 1, 2, 3 or 4;m is 0, 1 or 2;p is 1, 2, 3 or 4.
    Type: Grant
    Filed: March 13, 1980
    Date of Patent: February 24, 1981
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hermann Breuer
  • Patent number: 4233300
    Abstract: New derivatives of 8H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidine have the general formula ##STR1## The compounds are useful as anti-inflammatory agents and central nervous system depressants.
    Type: Grant
    Filed: November 13, 1979
    Date of Patent: November 11, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hans Hoehn
  • Patent number: 4223142
    Abstract: The new amino derivatives of pyrido[2,3-d]pyridazine carboxylic esters and acids have the general formula ##STR1## They are useful as analgesic, anti-inflammatory agents and central nervous system depressants. In addition, this type of compound increases the intracellular concentration of adenosine-3',5'-cyclic monophosphate.
    Type: Grant
    Filed: June 16, 1976
    Date of Patent: September 16, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hans Hoehn
  • Patent number: 4202899
    Abstract: New derivatives of 8H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]-pyrido[3,4-e]pyrimidine have the general formula ##STR1## The compounds are useful as anti-inflammatory agents and central nervous system depressants.
    Type: Grant
    Filed: April 21, 1976
    Date of Patent: May 13, 1980
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hans Hoehn
  • Patent number: 4128645
    Abstract: New 4H-pyrazolo[1,5-a]pyrazolo[4',3':5,6]pyrido[3,4-e]pyrimidin-5(8H)one and new derivatives thereof have the general formula ##STR1## The compounds are useful as anti-inflammatory agents and central nervous system depressants.
    Type: Grant
    Filed: September 1, 1977
    Date of Patent: December 5, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hans Hoehn
  • Patent number: 4127655
    Abstract: New derivatives of 8H-pyrazolo[4',3':5,6]pyrido[3,4-e]-[1,2,4]triazolo[1,5-a]pyrimidine have the general formula ##STR1## The compounds are useful as anti-inflammatory agents and central nervous system depressants.
    Type: Grant
    Filed: January 9, 1978
    Date of Patent: November 28, 1978
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Theodor Denzel, Hans Hoehn