Abstract: The present disclosure provides a prostacyclin coated implant to enhance fracture repair and bone formation comprising: an implant; and a prostacyclin coating comprising a prostacyclin compound disposed in a polymer coating the implant, wherein the prostacyclin coating releases the prostacyclin compound which enhances fracture repair and bone formation.

Abstract: The present disclosure provides a prostacyclin coated implant to enhance fracture repair and bone formation comprising: an implant; and a prostacyclin coating comprising a prostacyclin compound disposed in a polymer coating the implant, wherein the prostacyclin coating releases the prostacyclin compound which enhances fracture repair and bone formation.

Abstract: The present disclosure provides a prostacyclin coated implant to enhance fracture repair and bone formation comprising: an implant; and a prostacyclin coating comprising a prostacyclin compound disposed in a polymer coating the implant, wherein the prostacyclin coating releases the prostacyclin compound which enhances fracture repair and bone formation.

Abstract: A medication delivery system includes an array of cartridge-receiving ports, a medication receiving fluid conduit, and a plurality of dispensing elements. Each port includes a fluid channel terminating at a fluid outlet and is configured to receive one of a plurality of cartridges that each contain a bolus volume of medication. The medication-receiving fluid conduit is fluidically coupled to the fluid outlet of each cartridge-receiving port at a first region and to a system outlet conduit at a second region (which in turn can be coupled to a patient catheter line). Each dispensing element corresponds to a single cartridge-receiving port so that, upon activation of the dispensing element, at least a portion of the bolus volume of medication flows through the fluid outlet of each cartridge-receiving port into the medication-receiving fluid conduit. Related apparatus, systems, and methods are also disclosed.

Abstract: This document relates to FGF-23 polypeptides, FGF-23 polypeptide fragments, and methods for making and using such polypeptides and polypeptide fragments. For example, FGF-23 polypeptide fragments that can be used to treat disorders associated with hyperphosphatemia such as chronic renal failure and hypoparathyroidism are provided.

Abstract: A medication delivery system includes an array of cartridge-receiving ports, a medication receiving fluid conduit, and a plurality of dispensing elements. Each port includes a fluid channel terminating at a fluid outlet and is configured to receive one of a plurality of cartridges that each contain a bolus volume of medication. The medication-receiving fluid conduit is fluidically coupled to the fluid outlet of each cartridge-receiving port at a first region and to a system outlet conduit at a second region (which in turn can be coupled to a patient catheter line). Each dispensing element corresponds to a single cartridge-receiving port so that, upon activation of the dispensing element, at least a portion of the bolus volume of medication flows through the fluid outlet of each cartridge-receiving port into the medication-receiving fluid conduit. Related apparatus, systems, and methods are also disclosed.

Abstract: A medication delivery cartridge is described that includes a casing having an internal cavity extending between a proximal end and a distal end of the casing, a plunger translatable within the internal cavity that includes a penetrable fluid outlet, a volume of medicine contained within the internal cavity disposed between the plunger and the proximal end of the casing, and a first penetrable sterility barrier spanning the internal cavity proximate the distal end of the casing. Related apparatus, systems, and methods are also disclosed.

Abstract: A process for generating and deploying a real-time automatic independent learning plan (ILP) for a person based on academic curriculum standards. More specifically, an automated process is disclosed that includes as a first step testing and remediation for students to determine the assessment of that student's competency and mastery of certain academic disciplines, followed by the automatic generation, based on such assessment, of an ILP, which is a unique and individualized set of learning content assembled to assist the particular student in learning one or more process standards.

Abstract: A process for generating and deploying a real-time automatic independent learning plan (ILP) for a person based on academic curriculum standards. More specifically, an automated process is disclosed that includes as a first step testing and remediation for students to determine the assessment of that student's competency and mastery of certain academic disciplines, followed by the automatic generation, based on such assessment, of an ILP, which is a unique and individualized set of learning content assembled to assist the particular student in learning one or more process standards.