Patents by Inventor Theodore A. Martinot

Theodore A. Martinot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS
    Publication number: 20230008022
    Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
    Type: Application
    Filed: November 25, 2019
    Publication date: January 12, 2023
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dane Clausen, Ping Chen, Xavier Fradera, Liangqin Guo, Yongxin Han, Shuwen He, Xianhai Huang, Joseph Kozlowski, Guoqing Li, Theodore A. Martinot, Alexander Pasternak, Andreas Verras, Li Xiao, Feng Ye, Wensheng Yu, Rui Zhang
  • NOVEL SUBSTITUTED PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS
    Publication number: 20210395240
    Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
    Type: Application
    Filed: October 28, 2019
    Publication date: December 23, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dane Clausen, Xavier Fradera, Liangqin Guo, Yongxin Han, Shuwen He, Joseph Kozlowski, Guoqing Li, Theodore A. Martinot, Alexander Pasternak, David Sloman, Li Xiao, Wensheng Yu, Rui Zhang
  • NOVEL ARYLALKYL PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS
    Publication number: 20210380572
    Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
    Type: Application
    Filed: October 11, 2019
    Publication date: December 9, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dane Clausen, Ping Chen, Xavier Fradera, Liangqin Guo, Yongxin Han, Shuwen He, Jongwon Lim, Theodore A. Martinot, Alexander Pasternak, Li Xiao, Wensheng Yu
  • NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS
    Publication number: 20210330676
    Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
    Type: Application
    Filed: August 16, 2019
    Publication date: October 28, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Dane Clausen, Xavier Fradera, Liangqin Guo, Yongxin Han, Shuwen He, Xianhai Huang, Joseph Kozlowski, Guoqing Li, Jongwon Lim, Theodore A. Martinot, Alexander Pasternak, Nunzio Sciammetta, Andreas Verras, Li Xiao, Wensheng Yu, Rui Zhang
  • METHODS OF TREATING A FATTY ACID AMIDE HYDROLASE-MEDIATED CONDITION
    Publication number: 20180244700
    Abstract: The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same.
    Type: Application
    Filed: April 23, 2018
    Publication date: August 30, 2018
    Inventors: Brian C. Austad, Louis Grenier, Michael J. Grogan, Tao Liu, Priscilla L. White, Theodore A. Martinot, Lin-Chen Yu
  • Methods of treating a fatty acid amide hydrolase-mediated condition
    Patent number: 9951089
    Abstract: The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: April 24, 2018
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Brian C. Austad, Louis Grenier, Michael J. Grogan, Tao Liu, Priscilla L. White, Theodore A. Martinot, Lin-Chen Yu
  • FATTY ACID AMIDE HYDROLASE INHIBITORS
    Publication number: 20150239912
    Abstract: The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same.
    Type: Application
    Filed: February 25, 2015
    Publication date: August 27, 2015
    Inventors: Brian C. AUSTAD, Louis GRENIER, Michael J. GROGAN, Tao LIU, Priscilla L. WHITE, Theodore A. MARTINOT, Lin-Chen YU
  • Fatty acid amide hydrolase inhibitors
    Patent number: 9034849
    Abstract: The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: May 19, 2015
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Brian C. Austad, Louis Grenier, Michael J. Grogan, Tao Liu, Ching Kam Lo, Theodore A. Martinot, Lin-Chen Yu
  • Processes for producing phenyl-6-(1-(phenyl)ureido)nicotinamides)
    Patent number: 8461345
    Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: June 11, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Stefanie Roeper, Adam R. Looker, Theodore A. Martinot, Bobbianna Neubert-Langille, Michael P. Ryan, John R. Snoonian
  • Preparation of protected alpha-keto beta-amino esters and amides
    Patent number: 8378124
    Abstract: The invention provides ?-sulfonamide ?-keto esters and amides in which the ?-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.
    Type: Grant
    Filed: December 30, 2010
    Date of Patent: February 19, 2013
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: William A. Nugent, Adam R. Looker, Raymond E. Forslund, Theodore A. Martinot, Cristian L. Harrison, Shereen Ibrahim
  • PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES)
    Publication number: 20120316345
    Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
    Type: Application
    Filed: August 22, 2012
    Publication date: December 13, 2012
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Stefanie Roeper, Adam R. Looker, Theodore A. Martinot, Bobbianna Neubert-Langille, Michael P. Ryan, John R. Snoonian
  • Processes for producing phenyl-6-(1-(phenyl)ureido)nicotinamides
    Patent number: 8273896
    Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: September 25, 2012
    Assignee: Vertex Pharmaceutical Incorporated
    Inventors: Stefanie Roeper, Adam R. Looker, Theodore A. Martinot, Bobbianna Neubert-Langille, Michael P. Ryan, John R. Snoonian
  • Preparation of Protected Alpha-Keto Beta-Amino Esters and Amides
    Publication number: 20110213161
    Abstract: The invention provides ?-sulfonamide ?-keto esters and amides in which the ?-keto is protected as a 1,3-dithiolane derivative. Also provided are methods for preparing such esters and amides and for incorporating them into peptides.
    Type: Application
    Filed: December 30, 2010
    Publication date: September 1, 2011
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: William A. Nugent, Adam R. Looker, Raymond E. Forslund, Theodore A. Martinot, Cristian L. Harrison, Shereen Ibrahim
  • FATTY ACID AMIDE HYDROLASE INHIBITORS
    Publication number: 20110201574
    Abstract: The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same.
    Type: Application
    Filed: February 1, 2011
    Publication date: August 18, 2011
    Inventors: Brian C. AUSTAD, Louis Grenier, Michael J. Grogan, Tao Liu, Ching Kam Lo, Theodore A. Martinot, Lin-Chen Yu
  • PROCESSES FOR PRODUCING PHENYL-6-(1-(PHENYL)UREIDO)NICOTINAMIDES)
    Publication number: 20100234606
    Abstract: The present invention relates to processes for the preparation of compounds useful as inhibitors of p38 kinase. The processes of the present invention are amenable for large scale preparation and produce stable phenyl-6-(1-(phenyl)ureido)nicotinamides in high purity and yields.
    Type: Application
    Filed: February 12, 2010
    Publication date: September 16, 2010
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Stefanie Roeper, Adam R. Looker, Theodore A. Martinot, Bobbianna Neubert-Langille, Michael P. Ryan, John R. Snoonian