Patents by Inventor THEODORE E. CARVER

THEODORE E. CARVER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
    Publication number: 20040248851
    Abstract: The present invention is directed to a compound of Formula I: 1
    Type: Application
    Filed: July 14, 2004
    Publication date: December 9, 2004
    Inventors: Theodore E. Carver, James M. Rinker
  • Substituted 1,4-benzodiazepines and uses thereof
    Publication number: 20030109518
    Abstract: The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions.
    Type: Application
    Filed: November 13, 2002
    Publication date: June 12, 2003
    Inventors: Tianbao Lu, Louis V. Lafrance, Daniel J. Parks, Karen L. Milkiewicz, Raul R. Calvo, Maxwell D. Cummings, Alexander J. Kim, Bruce L. Grasberger, Theodore E. Carver
  • Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
    Publication number: 20030105111
    Abstract: The present invention is directed to a compound of Formula I: 1
    Type: Application
    Filed: October 9, 2002
    Publication date: June 5, 2003
    Applicant: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Theodore E. Carver, James M. Rinker
  • High throughput method for functionally classifying proteins identified using a genomics approach
    Publication number: 20020168686
    Abstract: The present invention provides a method for functionally classifying a protein that is capable of unfolding due to a thermal change. The method comprises screening one or more of a multiplicity of different molecules for their ability to shift the thermal unfolding curve of the protein, wherein a shift in the thermal unfolding curve indicates that the molecule binds to the protein or affects the stability in a measurable way; generating an activity spectrum for the protein wherein the activity spectrum reflects a set of molecules, from the multiplicity of molecules, that shift the thermal unfolding curve, of the protein and therefore are ligands that bind to the protein, comparing the activity spectrum for the protein to one or more functional reference spectrum lists; and classifying the protein according to the set of molecules in the multiplicity of different molecules that shift the thermal unfolding curve of the protein.
    Type: Application
    Filed: January 29, 2002
    Publication date: November 14, 2002
    Inventors: Michael W. Pantoliano, F. Raymond Salemme, Theodore E. Carver
  • HIGH THROUGHPUT METHOD FOR FUNCTIONALLY CLASSIFYING PROTEINS IDENTIFIED USING A GENOMICS APPROACH
    Publication number: 20010003648
    Abstract: The present invention provides a method for functionally classifying a protein that is capable of unfolding due to a thermal change. The method comprises screening one or more of a multiplicity of different molecules for their ability to shift the thermal unfolding curve of the protein, wherein a shift in the thermal unfolding curve indicates that the molecule binds to the protein or affects the stability in a measurable way; generating an activity spectrum for the protein wherein the activity spectrum reflects a set of molecules, from the multiplicity of molecules, that shift the thermal unfolding curve, of the protein and therefore are ligands that bind to the protein, comparing the activity spectrum for the protein to one or more functional reference spectrum lists; and classifying the protein according to the set of molecules in the multiplicity of different molecules that shift the thermal unfolding curve of the protein.
    Type: Application
    Filed: November 12, 1998
    Publication date: June 14, 2001
    Inventors: MICHAEL W. PANTOLIANO, F. RAYMOND SALEMME, THEODORE E. CARVER