Patents by Inventor Theodore E Carver, Jr.

Theodore E Carver, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High throughput method for functionally classifying proteins identified using a genomics approach
    Patent number: 7122321
    Abstract: The present invention provides a method for functionally classifying a protein that is capable of unfolding due to a thermal change. The method comprises screening one or more of a multiplicity of different molecules for their ability to shift the thermal unfolding curve of the protein, wherein a shift in the thermal unfolding curve indicates that the molecule binds to the protein or affects the stability in a measurable way; generating an activity spectrum for the protein wherein the activity spectrum reflects a set of molecules, from the multiplicity of molecules, that shift the thermal unfolding curve, of the protein and therefore are ligands that bind to the protein, comparing the activity spectrum for the protein to one or more functional reference spectrum lists; and classifying the protein according to the set of molecules in the multiplicity of different molecules that shift the thermal unfolding curve of the protein.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: October 17, 2006
    Assignee: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
    Inventors: Michael W Pantoliano, Francis R Salemme, Theodore E Carver, Jr.
  • Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
    Patent number: 7078406
    Abstract: The present invention is directed to a compound of Formula I: wherein A, R1, and R2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.
    Type: Grant
    Filed: July 14, 2004
    Date of Patent: July 18, 2006
    Assignee: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
    Inventors: Theodore E. Carver, Jr., James M. Rinker
  • Substituted 1,4-benzodiazepines and uses thereof
    Patent number: 7067512
    Abstract: The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: June 27, 2006
    Inventors: Tianbao Lu, Louis V Lafrance, III, Daniel J Parks, Karen L Milkiewicz, Raul R Calvo, Maxwell D Cummings, Alexander J Kim, Bruce L Grasberger, Theodore E Carver, Jr.
  • Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
    Patent number: 6815445
    Abstract: The present invention is directed to a compound of Formula I: wherein A, R1, and R2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: November 9, 2004
    Inventors: Theodore E. Carver, Jr., James M. Rinker