Patents by Inventor Theodore Goodson
Theodore Goodson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230147113Abstract: The present disclosure pertains to two-photon microscopy, and specifically to methods and systems for optimizing the performance of entangled two-photon absorption (ETPA) microscopy. An ETPA microscope is described with time delay tunability to optimize the coincidence of entangled photons on a sample. The optimization allows for increased two-photon absorption by the sample, resulting in increased luminescence of the sample. The ETPA microscopy systems and methods described allow for nonlinear imaging using excitation energy intensities six orders of magnitude lower than comparable two-photon absorption microscopy techniques using classical light.Type: ApplicationFiled: March 1, 2021Publication date: May 11, 2023Inventors: Oleg Varnavski, Theodore Goodson, III
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Patent number: 10357510Abstract: Provided herein are metal nanoclusters, having a high absorption to volume ratio, and uses of the same, such as in generating singlet oxygen, or in protecting surfaces from high intensity light.Type: GrantFiled: August 7, 2015Date of Patent: July 23, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Theodore Goodson, III, Oleg Varnavski, Sung Hei Yau
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Publication number: 20170216348Abstract: Provided herein are metal nanoclusters, having a high absorption to volume ratio, and uses of the same, such as in generating singlet oxygen, or in protecting surfaces from high intensity light.Type: ApplicationFiled: August 7, 2015Publication date: August 3, 2017Inventors: Theodore Goodson, III, Oleg Varnavski, Sung Hei Yau
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Patent number: 8179661Abstract: An organic dielectric material comprises a branched and/or hyperbranched macromolecule having delocalized electrons. Such macro-molecular organic material systems have desirable delocalized charge and optionally one or more micro-crystalline regions. Organic dielectric materials include, for example, branched polyanilines and phthalocyanines. Delocalized excitations within the macromolecular framework of the organic dielectric material may be used in various applications, such as light harvesting, nonlinear optical, quantum optical, and electronic applications, e.g., capacitors. Electrical devices may comprise such dielectric materials, including capacitors that have very high energy density, storage, and transfer. Also provided are methods of preparing such materials.Type: GrantFiled: June 27, 2008Date of Patent: May 15, 2012Assignee: The Regents of The University of MichiganInventors: Theodore Goodson, III, Xingzhong Yan
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Patent number: 7826053Abstract: An exemplary embodiment includes an apparatus having an energy source for selectively directing a first energy toward a first material. The at least a portion of the first energy excites a preselected second material to an excited state where at least two photons of the first energy are absorbed by the molecule of the second material causing the molecule to emit a second energy at about a predetermined wavelength. The apparatus also includes a control system for directing the first energy toward the first material. The apparatus also includes a detector for detecting at least a portion of the emitted second energy when the detector is more than about 40 meters from the molecule.Type: GrantFiled: October 1, 2007Date of Patent: November 2, 2010Assignee: The Regents of the University of MichiganInventors: Theodore Goodson, III, Oleg Varnavski
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Patent number: 7700628Abstract: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).Type: GrantFiled: November 10, 2005Date of Patent: April 20, 2010Assignee: Eli Lilly and CompanyInventors: Ankush Baburao Argade, Theodore Goodson, Jr., David Kent Herron, Sajan Joseph, Salvatore Donato Lepore, Angela Lynn Marquart, John Joseph Masters, David Mendel, Leander Merritt, Andrew Michael Ratz, Gerald Floyd Smith, Anne Louise Tebbe, Michael Robert Wiley, Ying Kwong Yee
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Publication number: 20090227566Abstract: This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).Type: ApplicationFiled: November 10, 2005Publication date: September 10, 2009Inventors: Ankush Baburao Argade, Theodore Goodson, JR., David Kent Herron, Sajan Joseph, Salvatore Donato Lepore, Angela Lynn Marquart, John Joseph Masters, David Mendel, Leander Merritt, Andrew Michael Ratz, Gerald Floyd Smith, Anne Lousie Tebbe, Michael Robert Wiley, Ying Kwong Yee
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Patent number: 7511066Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.Type: GrantFiled: September 24, 2004Date of Patent: March 31, 2009Assignee: Eli Lilly and CompanyInventors: Jeffry Bernard Franciskovich, Theodore Goodson, Jr., David Kent Herron, Angela Lynn Marquart, John Joseph Masters, David Mendel, Leander Merritt, Andrew Michael Ratz, Gerald Floyd Smith, Michael Robert Wiley, Ying Kwong Yee
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Patent number: 7511065Abstract: The present invention provides a compound of the formula: (Formula I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.Type: GrantFiled: November 12, 2003Date of Patent: March 31, 2009Assignee: Eli Lilly and CompanyInventors: Theodore Goodson, Jr., Mary Margaret Mader, John Eldon Toth, Arindam Chatterjee, Jason Scott Sawyer
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Publication number: 20090002919Abstract: An organic dielectric material comprises a branched and/or hyperbranched macromolecule having delocalized electrons. Such macro-molecular organic material systems have desirable delocalized charge and optionally one or more micro-crystalline regions. Organic dielectric materials include, for example, branched polyanilines and phthalocyanines. Delocalized excitations within the macromolecular framework of the organic dielectric material may be used in various applications, such as light harvesting, nonlinear optical, quantum optical, and electronic applications, e.g., capacitors. Electrical devices may comprise such dielectric materials, including capacitors that have very high energy density, storage, and transfer. Also provided are methods of preparing such materials.Type: ApplicationFiled: June 27, 2008Publication date: January 1, 2009Inventors: Theodore Goodson, III, Xingzhong Yan
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Publication number: 20080113977Abstract: The present invention provides a compound of the formula: (Formula I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of Formula I in combination with a suitable carrier, diluent, or excipient, and methods for treating physiological disorders, particularly congestive heart disease, comprising administering to a patient in thereof an effective amount of a compound of Formula I.Type: ApplicationFiled: November 12, 2003Publication date: May 15, 2008Inventors: Arindam Chatterjee, Theodore Goodson Jr, Mary Margaret Mader, John Eldon Toth
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Publication number: 20080079937Abstract: An exemplary embodiment includes an apparatus having an energy source for selectively directing a first energy toward a first material. The at least a portion of the first energy excites a preselected second material to an excited state where at least two photons of the first energy are absorbed by the molecule of the second material causing the molecule to emit a second energy at about a predetermined wavelength. The apparatus also includes a control system for directing the first energy toward the first material. The apparatus also includes a detector for detecting at least a portion of the emitted second energy when the detector is more than about 40 meters from the molecule.Type: ApplicationFiled: October 1, 2007Publication date: April 3, 2008Inventors: Theodore Goodson, III, Oleg Varnavski
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Publication number: 20070027185Abstract: This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.Type: ApplicationFiled: September 24, 2004Publication date: February 1, 2007Applicant: ELILILLY AND COMPANYInventors: Jeffry Franciskovich, Theodore Goodson, David Herron, Angela Marquart, John Masters, David Mendel, Leander Merritt, Andrew Ratz, Gerald Smith, Michael Wiley, Ying Yee
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Patent number: 7129245Abstract: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.Type: GrantFiled: July 29, 2003Date of Patent: October 31, 2006Assignee: Eli Lilly and CompanyInventors: Douglas Wade Beight, Trelia Joyce Craft, Carl Penman Denny, Jeffry Bernard Franciskovich, Theodore Goodson, Jr., Steven Edward Hall, David Kent Herron, Sajan Joseph, Valentine Joseph Klimkowski, Jeffrey Alan Kyle, John Joseph Masters, David Mendel, Guy Milot, Marta Maria Pi{hacek over (n)}elro-Nú{hacek over (n)}ez, Jason Scott Sawyer, Robert Theodore Shuman, Gerald Floyd Smith, Anne Louise Tebbe, Jennifer Marie Tinsley, Leonard Crayton Weir, James Howard Wikel, Michael Robert Wiley, Ying Kwong Yee
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Patent number: 7087626Abstract: Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors.Type: GrantFiled: May 13, 2002Date of Patent: August 8, 2006Assignee: Eli Lilly and CompanyInventors: Douglas Wade Beight, Todd Vincent DeCollo, Alexander Glenn Godfrey, Theodore Goodson, Jr., Hong-Yu Li, William Thomas McMillen, Shawn Christopher Miller, Jason Scott Sawyer, Edward C. R. Smith, Jonathan Michael Yingling
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Publication number: 20050282862Abstract: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.Type: ApplicationFiled: July 29, 2003Publication date: December 22, 2005Inventors: Douglas Beight, Trelia Craft, Carl Denny, Jeffry Franciskovich, Theodore Goodson, Steven Hall, David Herron, Sajan Joseph, Valentine Klimkowski, Jeffrey Kyle, John Masters, David Mendel, Guy Milot, Marta Pineiro-Nunez, Jason Sawyer, Robert Shuman, Gerald Smith, Anne Tebbe, Jennifer Tinsley, Leonard Weir, James Wikel, Michael Wiley, Ying Yee
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Patent number: 6780878Abstract: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.Type: GrantFiled: March 5, 2003Date of Patent: August 24, 2004Assignee: Eli Lilly and CompanyInventors: Douglas Wade Beight, Trelia Joyce Craft, Jeffry Bernard Franciskovich, Theodore Goodson, Jr., Steven Edward Hall, David Kent Herron, Sajan Joseph, Valentine Joseph Klimkowski, Jeffrey Alan Kyle, John Joseph Masters, David Mendel, Guy Milot, Marta Maria Piñeiro-Núñez, Jason Scott Sawyer, Robert Theodore Shuman, Gerald Floyd Smith, Anne Louise Tebbe, Jennifer Marie Tinsley, Leonard Crayton Weir, James Howard Wikel, Michael Robert Wiley, Ying Kwong Yee
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Patent number: 6759414Abstract: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.Type: GrantFiled: July 29, 2003Date of Patent: July 6, 2004Assignee: Eli Lilly and CompanyInventors: Douglas Wade Beight, Trelia Joyce Craft, Carl Penman Denny, Jeffry Bernard Franciskovich, Theodore Goodson, Jr., Steven Edward Hall, David Kent Herron, Sajan Joseph, Valentine Joseph Klimkowski, Jeffrey Alan Kyle, John Joseph Masters, David Mendel, Guy Milet, Marta Maria Piñeiro-Nuñez, Jason Scott Sawyer, Robert Theodore Shuman, Gerald Floyd Smith, Anne Louise Tebbe, Jennifer Marie Tinsley, Leonard Crayton Weir, James Howard Wikel, Michael Robert Wiley, Ying Kwong Yee
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Publication number: 20040106604Abstract: Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the structure (I) wherein (I) is a four, five, or six membered saturated ring and X is C, O or S.Type: ApplicationFiled: November 6, 2003Publication date: June 3, 2004Inventors: Douglas Beight, Todd DeCollo, Alexander Glenn Godfrey, Theodore Goodson, Hong-Yu Li, William McMillen, Shawn Christopher Miller, Jason Sawyer, Edward C.R. Smith, Jonathan Michael Yingling
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Patent number: 6716855Abstract: This application relates to a compound of formula I (or a pharmaceutically acceptable salt thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa, as well as a process for its preparation and intermediates therefor.Type: GrantFiled: February 25, 2003Date of Patent: April 6, 2004Assignee: Eli Lilly and CompanyInventors: Douglas Wade Beight, Trelia Joyce Craft, Jeffry Bernard Franciskovich, Theodore Goodson, Jr., Steven Edward Hall, David Kent Herron, Sajan Joseph, Valentine Joseph Klimkowski, Jeffrey Alan Kyle, John Joseph Masters, David Mendel, Guy Milot, Marta Maria Piñeiro-Núñez, Jason Scott Sawyer, Robert Theodore Shuman, Gerald Floyd Smith, Anne Louise Tebbe, Jennifer Marie Tinsley, Leonard Crayton Weir, James Howard Wikel, Michael Robert Wiley, Ying Kwong Yee