Patents by Inventor Theodore H. Stanley

Theodore H. Stanley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5855908
    Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to manufacturing techniques that enable therapeutic agents to be incorporated into nondissolvable drug containment matrixes which are capable of releasing the drug within a patient's mouth. An appliance or holder is preferably attached to the drug containment matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.
    Type: Grant
    Filed: November 15, 1994
    Date of Patent: January 5, 1999
    Assignee: University of Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5824334
    Abstract: The present invention relates generally to a cigarette substitute for administering a dose of nicotine. More specifically, the present invention is directed to a nicotine-containing dosage-form comprising a holder member which may be used as part of an effective smoking cessation program or in situations where smoking is undesirable or not permitted. The dosage form is configured as a dosage form having a nicotine-containing composition attached to a holder member. Nicotine is released from the dosage form and absorbed through the intra-oral mucosal surfaces as the nicotine-containing composition releases nicotine within a user's mouth. The holder member facilitates insertion and removal of the dosage form into and out of a user's mouth. The user can selectively insert and remove the dosage form as desired to selectively control the release of nicotine.
    Type: Grant
    Filed: April 19, 1996
    Date of Patent: October 20, 1998
    Assignee: University of Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian I. Hague
  • Patent number: 5785989
    Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored dissolvable matrix. An appliance or holder is preferably attached to the dissolvable matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: July 28, 1998
    Assignee: University Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5783207
    Abstract: The present invention relates to a selectively removable nicotine-containing dosage form for use in the transmucosal delivery of nicotine to a patient. More specifically, the present invention is directed to a nicotine-containing dosage-form comprising an attached holder member which may be used to manipulate the dosage form within the mouth of the patient as part of an effective smoking cessation program or in situations where smoking is undesirable or not permitted. Nicotine is released from a dosage form and absorbed through the intra-oral mucosal surfaces as the nicotine-containing matrix releases nicotine within the user's mouth. The user may selectively insert and remove the dosage form as desired to control the release of nicotine. In addition, the user may manipulate the dosage form by use of the holder means in such a manner to meet the user's psychological need or desire for ritualistic oral stimulation similar to cigarette smoking.
    Type: Grant
    Filed: February 4, 1997
    Date of Patent: July 21, 1998
    Assignee: University of Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5484602
    Abstract: The present invention is directed to methods and compositions for noninvasively administering drugs in a dose-to-effect manner to produce a cardiovascular or renal vascular activity. A cardiovascular or renal vascular drug, which is capable of absorption through mucosal tissues of the mouth, pharnyx, and esophagus is incorporated into a matrix which is in the form of a lollipop. A patient is put at ease when given the lollipop, and the drug rapidly enters the patient's bloodstream as the lollipop is sucked. When treating the patient, the physician can observe the patient's condition and remove the lollipop when it has had a desired effect on the patient. A lollipop into which a cardiovascular or renal vascular drug has been dispersed is particularly useful for achieving rapid vasodilating, calcium channel blocking, beta-blocking, seritonin receptor blocking, angina blocking, antihypertensive, and cardiac stimulating effects and for controlling urine output.
    Type: Grant
    Filed: January 20, 1995
    Date of Patent: January 16, 1996
    Assignee: University of Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5291887
    Abstract: The present invention is directed to novel methods and apparatus for noninvasively collecting substances through mucosal tissues. The concentration of a substance in blood is monitored noninvasively by correlation with the amount of the substance which permeates a mucosal membrane into a substance receiving medium over a specified time period. The substance receiving medium may include an substance permeation enhancer capable of increasing the substance permeability across the mucosal membrane. The substance receiving medium is positioned against the mucosal membrane. After sufficient time delay, the substance receiving medium is removed and analyzed for the concentration of a substance to be measured using known analytical techniques.The apparatus within the scope of the present invention includes means for supporting the substance receiving medium. The means for supporting the receiving medium provides an added benefit of isolating the substance receiving medium from contamination sources.
    Type: Grant
    Filed: June 2, 1992
    Date of Patent: March 8, 1994
    Assignee: Anesta Corporation
    Inventors: Theodore H. Stanley, Jie Zhang
  • Patent number: 5288498
    Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to manufacturing techniques that enable therapeutic agents to be incorporated into nondissolvable drug containment matrixes which are capable of releasing the drug within a patient's mouth. An appliance or holder is preferably attached to the drug containment matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: February 22, 1994
    Assignee: University of Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5288497
    Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering lipophilic and nonlipophilic drugs in a dose-to-effect manner that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored dissolvable matrix. An appliance or holder is preferably attached to the dissolvable matrix. Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: February 22, 1994
    Assignee: The University of Utah
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5139023
    Abstract: The present invention is directed to novel methods and apparatus for noninvasive blood glucose monitoring. Blood glucose is monitored noninvasively by correlation with amount of glucose which permeates an epithelial membrane, such as skin or a mucosal membrane, into a glucose receiving medium over a specified time period. The glucose receiving medium preferably includes a glucose permeation enhancer capable of increasing the glucose permeability across the epithelial membrane. The glucose receiving medium is positioned against the epithelial membrane so that the permeation enhancer alters the permeability of the membrane. After sufficient time delay, the glucose receiving medium is removed and analyzed for the presence of glucose using conventional analytical techniques.The apparatus within the scope of the present invention includes means for supporting the glucose receiving medium.
    Type: Grant
    Filed: June 2, 1989
    Date of Patent: August 18, 1992
    Assignees: TheraTech Inc., Stanley Research Foundation
    Inventors: Theodore H. Stanley, Charles D. Ebert, William I. Higuchi, Jie Zhang
  • Patent number: 5132114
    Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored confectionary base and to compress or otherwise attach the solid confectionary mixture onto an appliance or holder.Employing the present invention the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The present invention achieves these advantages by incorporating the drug into a compressed powder "candy" matrix.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: July 21, 1992
    Assignee: University of Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 5122127
    Abstract: Apparatus and methods for the dose-to-effect transmucosal administration of medicaments are disclosed. The present invention relates to such apparatus and methods which are useful in administering medicaments in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to an apparatus capable of placement directly on the patient's buccal mucosa having the capability of adjusting the drug surface area in direct contact with the mucosal tissue thereby enabling the proper amount of therapeutic agent or drug to be administered while accounting for individual needs and susceptibilities of the drug.Through the use of selected permeation enhancers, the present invention enables lipophilic and nonlipophilic medicaments, which are not suitable for oral administration, to be rapidly administered noninvasively.
    Type: Grant
    Filed: September 5, 1989
    Date of Patent: June 16, 1992
    Assignee: University of Utah
    Inventor: Theodore H. Stanley
  • Patent number: 4885173
    Type: Grant
    Filed: June 8, 1987
    Date of Patent: December 5, 1989
    Assignee: University of Utah
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 4863737
    Abstract: Compositions and methods of manufacture for producing a medicament composition capable of absorption through the mucosal tissues of the mouth, pharynx, and esophagus. The present invention relates to such compositions and methods which are useful in administering drugs in a dose-to-effect manner such that sufficient drug is administered to produce precisely a desired effect. The invention also relates to a manufacturing technique that enables a therapeutic agent or drug to be incorporated into a flavored confectionary base and to compress or otherwise attach the solid confectionary mixture onto an appliance or holder. Employing the present invention, the drug may be introduced into the patient's bloodstream almost as fast as through injection, and much faster than using the oral administration route, while avoiding the negative aspects of both of these methods. The present invention achieves these advantages by incorporating the drug into a compressed powder "candy " matrix.
    Type: Grant
    Filed: June 8, 1987
    Date of Patent: September 5, 1989
    Assignee: University of Utah
    Inventors: Theodore H. Stanley, Brian Hague
  • Patent number: 4671953
    Abstract: The present invention is directed to methods and compositions for noninvasively administering drugs having a sedative, analgesic, or anesthetic effect. A drug capable of absorption through mucosal tissues in incorporated into a candy matrix, which is then advantageously formed into a lollipop. A patient is put at ease when given the lollipop, and the drug rapidly enters the patient's bloodstream as the lollipop is sucked. When sedating or anesthetizing the patient, the physician can observe the patient's condition and remove the lollipop when it has had a desired effect on the patient. Alternatively, the physican can alter placement of the lollipop to slow the rate of the drug release for absorption into the patient's system. An analgesic-containing lollipop can be self-administrated by a patient in response to his own subjective experience of pain and to the patient's susceptibility to the particular drug utilized.
    Type: Grant
    Filed: May 1, 1985
    Date of Patent: June 9, 1987
    Assignee: University of Utah Research Foundation
    Inventors: Theodore H. Stanley, Brian Haque
  • Patent number: 3985141
    Abstract: An inflation and adjustable pressure relief apparatus for the inflatable cuff of an endotracheal tube, the apparatus having an adjustably spring-biased relief valve to automatically release gas pressures from the cuff above a preselected pressure level and a manually operable spring-biased valve for increasing the gas pressure in the cuff.
    Type: Grant
    Filed: March 10, 1975
    Date of Patent: October 12, 1976
    Assignee: The University of Utah
    Inventors: Theodore H. Stanley, Jerrold L. Foote