Abstract: 9-(5-O-Acyl-.beta.-D-arabinofuranosyl)adenine compounds and their production by reacting 9-(.beta.-D-arabinofuranosyl)adenine with a reactive derivative of an alkanoic acid. The compounds are useful as antiviral agents. The compounds are water-soluble and lipophilic, thereby being adaptable to a wide variety of pharmaceutical formulations.The present invention relates to new organic compounds that are useful in pharmacological agents and to a method for their production. More particularly, the invention relates to new 9-(5-O-acyl-.beta.-D-arabinofuranosyl)-adenine compounds that are represented by the formula ##STR1## where R is a straight chain alkanoyl group having from 2 to 8 carbon atoms or a branched chain alkanoyl group having 4 to 5 carbon atoms. Examples of alkanoyl groups represented by R are acetyl, propionyl, butyryl, pentanoyl, hexanoyl, octanoyl, 3-methylbutyryl, and 2,2-dimethylpropionyl.In accordance with the invention, 9-(5-O-acyl-.beta.

Abstract: 9-(3-O-Acyl-.beta.-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-.beta.-D-arabinofuranosyl)adenine compounds, and their production by reacting in each case the corresponding 5-silyl ether derivative with a tetraalkylammonium fluoride. The compounds are useful as antiviral agents. The compounds are water-soluble and lipophilic, thereby being adaptable to a wide variety of pharmaceutical formulations.

Abstract: O-2,6-diamino-2,4,6-trideoxy-.alpha.-D-xylo-hexopyranosyl-(1.fwdarw.4)-O-[5 -amino-5-deoxy-.beta.-D-xylofuranosyl-(1.fwdarw.5)]-N.sup.1 -[(S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxystreptamine, also named 5"-amino-4',5"-dideoxybutirosin A and acid addition salts of said compounds. These compounds exhibit a wide spectrum of antibacterial activity.The above compounds can be produced from O-2,6-dideoxy-2,6-bis(Z-amino)-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-O-[2, 3-di-O-acetyl-5-deoxy-5-(Z-amino)-.beta.-D-xylofuranosyl-(1.fwdarw.5)]-6-O- acetyl-N.sup.1 -[(S)-2-acetyloxy-1-oxo-4-(Z-amino)butyl]-2-deoxy-N.sup.3 -streptamine, also named protected 5"-aminodeoxybutirosin A by treating said compound with trifluoromethanesulfonic anhydride and pyridine to yield a mixture containing the 4'-O-(trifluoromethanesulfonyl) compound. The mixture is reacted with the sodium salt of an arylmercaptan and the resulting 4'-arylthio compound is purified and treated with ammonia, thus deprotecting the four hydroxy groups.

Abstract: O-2,6-diamino-2,3,6-trideoxy-.alpha.-D-ribo-hexo-pyranosyl-(1.fwdarw.4)-O-[ 5-amino-5-deoxy-.beta.-D-xylofuranosyl-(1.fwdarw.5)]-N.sup.1 -[(S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxystreptamine), also named 5"-amino-3',5"-dideoxybutirosin A and acid addition salts of said compounds. These compounds exhibit a wide spectrum of antibacterial activity.The above compounds can be produced from O-2,6-dideoxy-2,6-bis(Z-amino)-.alpha.-D-glucopyranosyl-(1.fwdarw.4)-O-[2, 3-di-O-acetyl-5-deoxy-5-(Z-amino)-.beta.-D-xylofuranosyl-(1.fwdarw. 5)]-6-O-acetyl-N.sup.1 -[(S)-2-acetyloxy-1-oxo-4-(Z-amino)butyl]-2-deoxy-N.sup. 3 -streptamine, also named protected 5"-amino-deoxybutirosin A by treating said compound with trifluoromethanesulfonic anhydride and pyridine to yield the 3'-O-(trifluoromethanesulfonyl) compound. The product is reacted with the sodium salt of an arylmercaptan and the resulting 3'-arylthio compound is purified and treated with ammonia, thus deprotecting the four hydroxy groups.