Abstract: Method and apparatus for internal examination of human and other subjects employing special catheters and biopsy wires, in combination with sonographic or fluoroscopic transducers, to provide unprecedented accuracy, economy, and efficiency in internal examination, diagnosis, biopsy, and surgical removal of lesions, tumors, polyps, etc. from bodies. In one aspect the invention provides an apparatus for use in combination with a sonographic transducer for examination and performing biopsies within a vaginal and uterine chamber of a human female and other bodies, whereby the apparatus is comprised of a substantially tubular catheter and any of a wide variety of biopsy devices adapted for disposition on or within the catheter. In another aspect, the invention provides a method of using sonographic or fluoroscopic imaging in combination with the apparatus to examine the cavities under study and to guide the apparatus during a biopsy procedure.