Abstract: Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides a method of treating subjects suffering from an autoimmune disorder, the method comprising administering an alternative to anti-TNF therapy to subjects who have been determined to be non-responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy.

Abstract: A method for remote intervention for a subject includes acquiring an image of a region of interest of the subject using an interventional device positioned on the subject and an image acquisition system. The region of interest includes a target structure and the subject is located at a first site. The method further includes analyzing the acquired image using an image analysis module to identify and label the target structure in the region of interest and transmitting the labelled image from the first site to a second site for expert review. The second site is remote from the first site. The method further includes receiving a command signal at the first site from the second site where the command signal is generated based on the expert review of the labelled image and configured to control an action of the interventional device. In some embodiments, the method may further include analyzing the acquired image to determine a pathway to the vessel that avoids critical structures.

Abstract: Presented herein are systems and methods for developing classifiers useful for predicting response to particular treatments. For example, in some embodiments, the present disclosure provides a method of treating subjects suffering from an autoimmune disorder, the method comprising administering an alternative to anti-TNF therapy to subjects who have been determined to be non-responsive via a classifier established to distinguish between responsive and non-responsive prior subjects in a cohort who have received the anti-TNF therapy.

Abstract: Apparatus and method for summarizing an original large data set with a representative data set. The data elements in both the original data set and the representative data set have the same variables, but there are significantly fewer data elements in the representative data set. Each data element in the representative data set has an associated weight, representing the degree of compression. There are three steps for constructing the representative data set. First, the original data elements are partitioned into separate bins. Second, moments of the data elements partitioned in each bin are calculated. Finally, the representative data set is generated by finding data elements and associated weights having substantially the same moments as the original data set.

Abstract: A waste fuel combustion system including a furnace having a grate for supporting waste fuel for burning, the grate including a plurality of movable members and a mechanism for reciprocating the movable members. The furnace also includes a primary gas passageway, a secondary gas passageway, and a throat through which the primary and secondary gas passageways pass in order to accelerate the flow of combustion gases. The waste fuel combustion system also includes recirculation conduits communicating between a source of exhaust gases and the primary and secondary gas passageways in order to recirculate the exhaust gases for additional combustion and degradation.

Abstract: A furnace adapted to burn wood chips and wood particles and including an inner cylinder adapted to be positioned in horizontal relation and including a primary combustion area. A funnel assembly is provided for supporting a quantity of wood particles and for funneling the wood particles into the primary combustion area of the inner cylinder. A second cylinder is also provided, the second cylinder having a length greater than that of the inner cylinder and having one end which surrounds the inner cylinder such that the inner cylinder and the second cylinder define an air space therebetween. The other end of the second cylinder defines a secondary combustion area where the combustion gases from the primary combustion area are mixed with secondary air.