Abstract: The present invention provides a device, a system, and a method for application of fluids.

Abstract: A syringe fill system is described, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for “push-pull”, “pull-push”, “push-push”, and “pull-pull” modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe Tillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system.

Abstract: A syringe fill system is described, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for “push-pull”, “pull-push”, “push-push”, and “pull-pull” modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe Tillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system.

Abstract: An automatically locking safety device, e.g., for use in a blood collection procedure, can include a housing, first and second needle covers that are at least partly received in the housing, and a needle that is at least partly received in at least one of the first and second needle covers. The needle can include a proximal tip configured for placement into a patient and a distal tip configured for placement into a blood collection vial. In some embodiments, the first and second needle covers are biased by a biasing member. In some cases, one or both of the first and second needle covers can be locked to prevent axial movement thereof after the blood collection procedure. In certain embodiments, a distal end of the device is configured to connect with a medical connector, such as a needleless IV access device.

Abstract: A syringe fill system is described, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for “push-pull”, “pull-push”, “push-push”, and “pull-pull” modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe fillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system.

Abstract: Methods are disclosed, for performing therapeutic or diagnostic procedures at a remote site. According to one embodiment, the methods include the use of a system including an introducer designed for transcervical insertion into the uterus. The introducer is constructed to include a fluid lumen, an instrument lumen, and a visualization lumen. The system may include a fluid source, which is coupled to the fluid lumen and is used to deliver a fluid to the uterus either for washing the uterus or for fluid distension of the uterus. The system additionally includes a tissue modifying device, such as a morcellator, and a distension device for distending the uterus and/or for maintaining the uterus in a distended state. The tissue modifying device and the distension device are alternately deliverable to the uterus through the instrument lumen. The system may further include a hysteroscope deliverable to the uterus through the visualization lumen.

Abstract: A syringe fill system is described, which is useful for filling syringes for dental anesthetic applications. The system incorporates capability for “push-pull”, “pull-push”, “push-push”, and “pull-pull” modes of operation, for loading syringes with compositions comprising multiple fluid components. A syringe fillable by such syringe fill systems is described, providing haptic and audible feedback to a user, to aid in administering precise amounts of therapeutic compositions. Also disclosed are cassette assemblies for use in such syringe fill systems. Such cassette assemblies may be formed of plastic and elastomeric materials of construction, as disposable or single-use components of the syringe fill system.

Abstract: A fluid transfer device comprising a housing and a flow controller at least partially slidably disposed in the housing, the flow controller comprising at least one fluid channel and a vent conduit. A shroud, alone or in combination with the fluid transfer device comprising a plurality of segments terminating in a annular edge and defining a plurality of openings, and a plurality of protrusions, each of the plurality of protrusions having a proximal end connected to the annular edge and a distal end positioned in one of the plurality of openings adapted for the housing of the fluid transfer device is provided.

Abstract: A surgical tool comprises a manipulator adapted to receive at least a portion of a hand of an operator. A proximal universal joint has a first end mounted to the manipulator. A hollow elongated member has a first end mounted to a second end of the proximal universal joint. A distal universal joint has a first end mounted to a second end of the elongated member. An end effector comprises a universal joint element pivotally mounted to a second end of the distal universal joint for rotation about a first axis, and a base member pivotally connected to the joint element for rotation about a second axis perpendicular to the first axis. Pivoting of the first end of the proximal universal joint causes the end effector to move in a corresponding motion.

Abstract: A valve is disclosed, the valve comprising a housing having an first opening and a second opening, and an elastomeric member positioned in the housing, the elastomeric member comprising a thickness, a continuous peripheral wall projecting from the thickness, and a slit extending through the thickness, a continuous portion of the peripheral wall creating a continuous sealable contact with the housing and partitioning the housing into an upper section and a lower section, the elastomeric member configured such that upon creating a pressure differential between the upper section and the lower section of the housing causes either: (i) the peripheral wall to deflect from the housing permitting fluid flow around the elastomeric member; or (ii) the slit to open permitting fluid flow through the elastomeric member. Methods using the valve are also disclosed.

Abstract: Dispenser and methods of dispensing substances is provided. The dispenser comprises a housing having a longitudinal axis, the housing configured to receive a packet comprising at least one collapsible cavity containing at least one substance, a support member positioned in the housing, the support member having a longitudinal axis essentially parallel to the longitudinal axis of the housing, a wedge coupled to the support member, the wedge configured to move in a plane substantially parallel within the longitudinal axis of the housing, the wedge receiving a force directed substantially normal to the longitudinal axis of the housing, and a reciprocating actuator coupled to the housing and engagable with the support member, the actuator moveable between a first position and a second position whereby the wedge advances a single predetermined increment collapsing a portion of the cavity.

Abstract: A multi-container transfer and delivery device configured to allow multiple containers to transfer and mix their respective materials and for receiving of the mixed materials to a delivery device. The transfer device comprises a plurality of flow conduits for fluid flow between the multiple containers and the delivery device. Methods of mixing using the device and methods of sterilizing the device are described. A drug mixing kit comprising a multi-container housing with a plurality of flow conduits and a plurality of compartments for receiving containers and a transfer device is also described.

Abstract: In one aspect, the invention is directed to a port assembly for establishing fluid communication between a first container and a second container. The port assembly includes a retainer for connecting a first container, where the retainer is positioned in a cavity defined by a port housing that includes an axially fixed actuator. The housing also includes a plug member constructed to seal a fluid passageway between the port housing and an interior of a second container. The plug member is configured to move axially relative to the actuator. Rotation of the retainer relative to the actuator causes the plug member to move to an open position in which it does not seal a fluid passageway between the port housing and an interior of a second container. The rotation of the retainer relative to the port housing also causes the retainer to move axially relative to the port housing so that the actuator forces a stopper associated with a first container connected to the retainer into a first container.

Abstract: Dispenser and methods of dispensing substances is provided. The dispenser comprises a housing having a longitudinal axis, the housing configured to receive a packet comprising at least one collapsible cavity containing at least one substance, a support member positioned in the housing, the support member having a longitudinal axis essentially parallel to the longitudinal axis of the housing, a wedge coupled to the support member, the wedge configured to move in a plane substantially parallel within the longitudinal axis of the housing, the wedge receiving a force directed substantially normal to the longitudinal axis of the housing, and a reciprocating actuator coupled to the housing and engagable with the support member, the actuator moveable between a first position and a second position whereby the wedge advances a single predetermined increment collapsing a portion of the cavity.

Abstract: A blunt cannula includes a distal portion and a proximal portion. The distal portion has a non-uniform taper defined by a plurality, such as four, differently tapered segments. The proximal portion may additionally or alternatively have a non-circular, such as oval, cross-section. At least the major diameter (D.sub.MAJ) of the proximal portion my taper toward the distal portion.

Abstract: The anti-back-flow devices and methods prevent fluid from leaking proximally from a catheter, but allow ready access to the catheter using any male luer device. The devices include proximal surfaces that urge open a valve in response to force from a male luer tip. The valves are associated a female luer hub and adapted to function with standard and typical non-standard male luer fittings.