Patents by Inventor Theodore Lee ROTH

Theodore Lee ROTH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TARGETED NON-VIRAL DNA INSERTIONS
    Publication number: 20240117360
    Abstract: Provided herein are methods and compositions for editing the genome of a cell. In some embodiments, a nucleotide sequence of at least 200 nucleotides in length is inserted into a target region in the genome of a cell.
    Type: Application
    Filed: September 8, 2023
    Publication date: April 11, 2024
    Inventors: Theodore Lee Roth, Alexander Marson
  • Targeted non-viral DNA insertions
    Patent number: 11814624
    Abstract: Provided herein are methods and compositions for editing the genome of a cell. In some embodiments, a nucleotide sequence of at least 200 nucleotides in length is inserted into a target region in the genome of a cell.
    Type: Grant
    Filed: October 11, 2021
    Date of Patent: November 14, 2023
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Theodore Lee Roth, Alexander Marson
  • TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
    Publication number: 20230310502
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Application
    Filed: January 27, 2023
    Publication date: October 5, 2023
    Applicant: The Regents of the University of California
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • POOLED KNOCK-IN SCREENING AND HETEROLOGOUS POLYPEPTIDES CO-EXPRESSED UNDER THE CONTROL OF ENDOGENOUS LOCI
    Publication number: 20230066806
    Abstract: Provided herein are methods and compositions for identifying a targeted genomic insertion in a cell. Also provided are heterologous polypeptides that are co-expressed under the control of enodogenous loci and methods of using same.
    Type: Application
    Filed: March 13, 2020
    Publication date: March 2, 2023
    Applicant: The Regents of the University of California
    Inventors: Theodore Lee Roth, Po-Yi Jonathan Li, Alexander Marson, Jasper Nies, Cody Mowery, Eric Shifrut, Franziska Blaeschke, Ryan Apathy
  • Targeted replacement of endogenous T cell receptors
    Patent number: 11590171
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Grant
    Filed: April 20, 2022
    Date of Patent: February 28, 2023
    Assignee: The Regents of the University of California
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
    Publication number: 20220241336
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Application
    Filed: April 20, 2022
    Publication date: August 4, 2022
    Applicant: Regents of the University of California
    Inventors: Theodore Lee ROTH, Eric SHIFRUT, Alexander MARSON, Cristina PUIG SAUS, Antoni RIBAS
  • Targeted replacement of endogenous T cell receptors
    Patent number: 11331346
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Grant
    Filed: July 30, 2021
    Date of Patent: May 17, 2022
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • TARGETED NON-VIRAL DNA INSERTIONS
    Publication number: 20220064653
    Abstract: Provided herein are methods and compositions for editing the genome of a cell. In some embodiments, a nucleotide sequence of at least 200 nucleotides in length is inserted into a target region in the genome of a cell.
    Type: Application
    Filed: October 11, 2021
    Publication date: March 3, 2022
    Inventors: Theodore Lee Roth, Alexander Marson
  • COMPOSITIONS AND METHODS FOR MODIFYING A TARGET NUCLEIC ACID
    Publication number: 20220017882
    Abstract: The disclosure provides compositions and methods for modifying a target nucleic acid. In some embodiments, a composition can include a targetable nuclease, a DNA-binding protein, and a donor template comprising a homology directed repair (HDR) template and one or more DNA-binding protein target sequences. In some embodiments, a composition can include a Cas protein, one or more single guide RNAs (sgRNAs), and an anionic polymer.
    Type: Application
    Filed: December 12, 2019
    Publication date: January 20, 2022
    Inventors: Alexander Marson, Theodore Lee Roth, Daniel Goodman, David-Huy Nhu Nguyen, Francis C. Szoka
  • TARGETED NON-VIRAL DNA INSERTIONS
    Publication number: 20210388362
    Abstract: Provided herein are methods and compositions for editing the genome of a cell. In some embodiments, a nucleotide sequence of at least 200 nucleotides in length is inserted into a target region in the genome of a cell.
    Type: Application
    Filed: May 20, 2021
    Publication date: December 16, 2021
    Inventors: Theodore Lee Roth, Alexander Marson
  • TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
    Publication number: 20210353678
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Application
    Filed: July 30, 2021
    Publication date: November 18, 2021
    Applicant: Regents of the University of California
    Inventors: Theodore Lee ROTH, Eric SHIFRUT, Alexander Marson, Cristina PUIG SAUS, Antoni RIBAS
  • Targeted replacement of endogenous T cell receptors
    Patent number: 11083753
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: August 10, 2021
    Assignee: The Regents of the University of California
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
    Publication number: 20210228631
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Application
    Filed: March 12, 2021
    Publication date: July 29, 2021
    Inventors: Theodore Lee Roth, Eric SHIFRUT, Alexander MARSON, Cristina PUIG SAUS, Antoni RIBAS
  • GENETIC ENGINEERING OF ENDOGENOUS PROTEINS
    Publication number: 20210207174
    Abstract: Provided herein are methods and compositions for modifying an endogenous cell surface protein in a human cell by inserting a heterologous nucleic acid sequence in a target region of a nucleic acid encoding the endogenous cell surface protein.
    Type: Application
    Filed: May 24, 2019
    Publication date: July 8, 2021
    Inventors: Theodore Lee ROTH, Po-Yi Jonathan LI, Alexander MARSON
  • Targeted replacement of endogenous T cell receptors
    Patent number: 11033584
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Grant
    Filed: September 11, 2019
    Date of Patent: June 15, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Theodore Lee Roth, Eric Shifrut, Alexander Marson, Cristina Puig Saus, Antoni Ribas
  • TARGETED NON-VIRAL DNA INSERTIONS
    Publication number: 20200362355
    Abstract: Provided herein are methods and compositions for editing the genome of a cell. In some embodiments, a nucleotide sequence of at least 200 nucleotides in length is inserted into a target region in the genome of a cell.
    Type: Application
    Filed: June 15, 2018
    Publication date: November 19, 2020
    Inventors: Theodore Lee Roth, Alexander Marson
  • TARGETED REPLACEMENT OF ENDOGENOUS T CELL RECEPTORS
    Publication number: 20200000851
    Abstract: Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-? chain and a heterologous TCR-? chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
    Type: Application
    Filed: September 11, 2019
    Publication date: January 2, 2020
    Inventors: Theodore Lee ROTH, Eric SHIFRUT, Alexander MARSON, Cristina Puig SAUS, Antoni RIBAS