Patents by Inventor Theodore Maione

Theodore Maione has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for identifying markers
    Publication number: 20080249715
    Abstract: The invention is a method for identifying markers associated with the presence of a predetermined characteristic comprising accumulating spectral data from a sample known to have a predetermined characteristic, identifying a spectral feature which is indicative of the predetermined characteristic, and identifying a marker associated with the spectral feature.
    Type: Application
    Filed: June 3, 2004
    Publication date: October 9, 2008
    Inventor: Theodore Maione
  • Method for identifying markers
    Publication number: 20050273267
    Abstract: The invention is a method for identifying markers associated with the presence of a predetermined characteristic comprising accumulating spectral data from a sample known to have a predetermined characteristic, identifying a spectral feature which is indicative of the predetermined characteristic, and identifying a marker associated with the spectral feature.
    Type: Application
    Filed: June 3, 2004
    Publication date: December 8, 2005
    Inventor: Theodore Maione
  • Systemic treatment of metastatic cancer with platelet factor 4
    Patent number: 5284827
    Abstract: The subject invention concerns a novel treatment for cancer. Specifically, the invention concerns the systemic administration of recombinant Platelet Factor Four (rPF4) to inhibit tumor growth in a mammal having metastatic cancer.
    Type: Grant
    Filed: October 19, 1990
    Date of Patent: February 8, 1994
    Assignee: Repligen Corporation
    Inventors: Theodore Maione, Richard J. Sharpe
  • Modified PF4 compositions and methods of use
    Patent number: 5112946
    Abstract: The subject invention pertains to the use of modified PF4 and recombinant PF4(rPF4) as well as modified analogs (mutants) of PF4, and peptide fragments thereof, to inhibit angiogenesis. The modified PF4, analogs, and certain fragments are shown to have utility for treating angiogenic diseases and for the inhibition of endothelial cell proliferation. Also, the subject invention concerns modification of PF4 which facilitate the targeting of the biological activity of PF4 to specific locations.
    Type: Grant
    Filed: July 6, 1989
    Date of Patent: May 12, 1992
    Assignee: Repligen Corporation
    Inventor: Theodore Maione
  • Novel methods and compositions for treatment of angiogenic diseases
    Patent number: 5086164
    Abstract: The subject invention pertains to the use of recombinant PF4 (rPF4) as well as full length novel analogs (mutants) of rPF4, and peptide fragments thereof, to inhibit angiogenesis. rPF4, analogs, and certain fragments are shown to have utility for treating angiogenic diseases and for the inhibition of endothelial cell proliferation.
    Type: Grant
    Filed: December 27, 1989
    Date of Patent: February 4, 1992
    Assignee: Repligen Corporation
    Inventors: Theodore Maione, Richard J. Sharpe