Patents by Inventor Theodore Malinin

Theodore Malinin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10549011
    Abstract: A collagen-bone composition may include bone collagen and bone particles. The collagen may be in the form of a collagen suspension and the bone particles may be demineralized bone particles retained in collagen suspension. The composition may be prepared from pressure and thermal treatment of dry demineralized bone particles contacted with an aqueous medium to produce a viscous gel-like fluid. The fluid may include the collagen extracted from the demineralized bone particles. Addition of particulate bone may be used to increase the consistency of the composition, which may convert it into a paste or putty. The paste or putty may be suitable for ejection from a syringe. The collagen-bone composition may be preserved by freeze-drying or preferably by hypothermic dehydration. On reconstitution with aqueous medium, the preserved material may resume its original shape and properties.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: February 4, 2020
    Assignee: Osteolife Biomedical, LLC
    Inventor: Theodore Malinin
  • Publication number: 20190030209
    Abstract: The present application relates to bioactive implants, methods of making bioactive implants, and methods of using bioactive implants to treat or repair a bone defect or a cartilage defect. In an aspect, the present application relates to compositions comprising bone microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, the present application relates to compositions comprising cartilage microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, disclosed herein are methods of making and using the disclosed compositions comprising bone microparticles and the disclosed composition comprising cartilage microparticles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: October 1, 2018
    Publication date: January 31, 2019
    Applicant: Osteolife Biomedical, LLC
    Inventor: Theodore Malinin
  • Patent number: 9839524
    Abstract: An allogeneic or xenogeneic implant for intervertebral disc replacement includes a body. The body may include one or both of a plurality of grooves or tubular apertures. The body may be formed of partially decalcified bone. The plurality of tubular apertures may be defined within the body and be positioned to allow inflow of decalcifying solutions for rapid and uniform decalcification. After partial decalcification, the body may be pliable and compressible.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: December 12, 2017
    Inventor: Theodore Malinin
  • Publication number: 20170266355
    Abstract: The present application relates to bioactive implants, methods of making bioactive implants, and methods of using bioactive implants to treat or repair a bone defect or a cartilage defect. In an aspect, the present application relates to compositions comprising bone microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, the present application relates to compositions comprising cartilage microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, disclosed herein are methods of making and using the disclosed compositions comprising bone microparticles and the disclosed composition comprising cartilage microparticles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Inventor: Theodore Malinin
  • Publication number: 20170202645
    Abstract: A method of preparing a bone graft of compressed dehydrated decalcified trabecular bone may include compressing the bone while hydrated from a first form to a second form such that the bone in the second form is compressed relative to the first form. The bone may be dried while compressed. When dry, the bone substantially retains the second form and does not revert to the first form when the compression is removed.
    Type: Application
    Filed: April 3, 2017
    Publication date: July 20, 2017
    Applicant: Osteolife Biomedical, LLC
    Inventors: Theodore Malinin, Arun K. Garg
  • Publication number: 20170128633
    Abstract: The present application relates to bioactive implants, methods of making bioactive implants, and methods of using bioactive implants to treat or repair a bone defect or a cartilage defect. In an aspect, the present application relates to compositions comprising bone microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, the present application relates to compositions comprising cartilage microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, disclosed herein are methods of making and using the disclosed compositions comprising bone microparticles and the disclosed composition comprising cartilage microparticles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: November 10, 2015
    Publication date: May 11, 2017
    Inventor: Theodore Malinin
  • Publication number: 20170128634
    Abstract: The present application relates to bioactive implants, methods of making bioactive implants, and methods of using bioactive implants to treat or repair a bone defect or a cartilage defect. In an aspect, the present application relates to compositions comprising bone microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, the present application relates to compositions comprising cartilage microparticles in a solution, wherein the compositions harden upon desiccation into bioactive implants. In an aspect, disclosed herein are methods of making and using the disclosed compositions comprising bone microparticles and the disclosed composition comprising cartilage microparticles. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
    Type: Application
    Filed: November 10, 2015
    Publication date: May 11, 2017
    Inventor: Theodore Malinin
  • Publication number: 20170112963
    Abstract: A collagen-bone composition may include bone collagen and bone particles. The collagen may be in the form of a collagen suspension and the bone particles may be demineralized bone particles retained in collagen suspension. The composition may be prepared from pressure and thermal treatment of dry demineralized bone particles contacted with an aqueous medium to produce a viscous gel-like fluid. The fluid may include the collagen extracted from the demineralized bone particles. Addition of particulate bone may be used to increase the consistency of the composition, which may convert it into a paste or putty. The paste or putty may be suitable for ejection from a syringe. The collagen-bone composition may be preserved by freeze-drying or preferably by hypothermic dehydration. On reconstitution with aqueous medium, the preserved material may resume its original shape and properties.
    Type: Application
    Filed: October 26, 2015
    Publication date: April 27, 2017
    Inventor: Theodore Malinin
  • Patent number: 9610143
    Abstract: A method of preparing a bone graft of compressed dehydrated decalcified trabecular bone may include compressing the bone while hydrated from a first form to a second form such that the bone in the second form is compressed relative to the first form. The bone may be dried while compressed. When dry, the bone substantially retains the second form and does not revert to the first form when the compression is removed.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: April 4, 2017
    Assignee: Osteolife Biomedical, LLC
    Inventors: Theodore Malinin, Arun K. Garg
  • Publication number: 20160367376
    Abstract: An allogeneic or xenogeneic implant for intervertebral disc replacement includes a body. The body may include one or both of a plurality of grooves or tubular apertures. The body may be formed of partially decalcified bone. The plurality of tubular apertures may be defined within the body and be positioned to allow inflow of decalcifying solutions for rapid and uniform decalcification. After partial decalcification, the body may be pliable and compressible.
    Type: Application
    Filed: June 22, 2015
    Publication date: December 22, 2016
    Inventor: Theodore Malinin
  • Publication number: 20150366641
    Abstract: A method of preparing a bone graft of compressed dehydrated decalcified trabecular bone may include compressing the bone while hydrated from a first form to a second form such that the bone in the second form is compressed relative to the first form. The bone may be dried while compressed. When dry, the bone substantially retains the second form and does not revert to the first form when the compression is removed.
    Type: Application
    Filed: June 19, 2014
    Publication date: December 24, 2015
    Inventors: Theodore Malinin, Arun K. Garg
  • Patent number: 9101424
    Abstract: A flexible, bendable organic decalcified or partially decalcified bone, cortical or cancellous, adapted for use in augmentation or repair of animal skeletal structures comprising a continuous plate or sheet of natural bone, as well as dermis is described. The thickness, flexibility and tensile strength of the construct is such as to allow it to be shaped and contoured without damage to it. The composition is ultimately remodeled by the body, thus obviating the need for additional surgical intervention. The clinical indications for the use of the invented construct are many, but are particularly prominent in dentistry, oral and maxillofacial surgery and implantology. It is particularly useful in the maxillary sinus augmentation. A unique new method, different from previously described methods for the preparation of the disclosed constructs, is described.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: August 11, 2015
    Inventor: Theodore Malinin
  • Publication number: 20150216665
    Abstract: A flexible, bendable organic decalcified or partially decalcified bone, cortical or cancellous, adapted for use in augmentation or repair of animal skeletal structures comprising a continuous plate or sheet of natural bone, as well as dermis is described. The thickness, flexibility and tensile strength of the construct is such as to allow it to be shaped and contoured without damage to it. The composition is ultimately remodeled by the body, thus obviating the need for additional surgical intervention. The clinical indications for the use of the invented construct are many, but are particularly prominent in dentistry, oral and maxillofacial surgery and implantology. It is particularly useful in the maxillary sinus augmentation. A unique new method, different from previously described methods for the preparation of the disclosed constructs, is described.
    Type: Application
    Filed: November 17, 2014
    Publication date: August 6, 2015
    Inventor: Theodore Malinin
  • Patent number: 8888823
    Abstract: A flexible, bendable organic decalcified or partially decalcified bone, cortical or cancellous, adapted for use in augmentation or repair of animal skeletal structures comprising a continuous plate or sheet of natural bone, as well as dermis is described. The thickness, flexibility and tensile strength of the construct is such as to allow it to be shaped and contoured without damage to it. The composition is ultimately remodeled by the body, thus obviating the need for additional surgical intervention. The clinical indications for the use of the invented construct are many, but are particularly prominent in dentistry, oral and maxillofacial surgery and implantology. It is particularly useful in the maxillary sinus augmentation. A unique new method, different from previously described methods for the preparation of the disclosed constructs, is described.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: November 18, 2014
    Inventor: Theodore Malinin
  • Publication number: 20110208305
    Abstract: A solid implantable bone construct (12) shaped like a cylinder, a cone, or a frustum, for anchoring ligament implants. The bone construct (12) can include a bone component and a biocompatible solid component. The bone component can include particulate bone of between 75 and 600 microns, powdered bone of 75 microns or smaller in size, or both. The biocompatible solid component can include calcium sulfate hemihydrate, a calcium phosphate product, or both. The bone component can be between 5 and 50 wt-% of the construct (12) and the biocompatible solid component can be at least 50 wt-% of the construct (12). Also disclosed is a composite graft (10) comprising a first bone dowel (12) and a ligament (20) and a method of securing one bone to another using the composite graft (10).
    Type: Application
    Filed: August 5, 2009
    Publication date: August 25, 2011
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Theodore Malinin, Temple H. Thomas
  • Patent number: 7838040
    Abstract: Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a distribution of particle sizes within the range of from about 60 microns to about 500 microns.
    Type: Grant
    Filed: November 28, 2006
    Date of Patent: November 23, 2010
    Inventor: Theodore Malinin
  • Publication number: 20070135928
    Abstract: Provided are procedures and instruments for preparing and transplanting osteochondral allograft plugs to a host bone to repair an articular cartilage defect. An allograft bone plug having a cartilage plate and cancellous bone tissue attached thereto is removed from a donor bone. The allograft plug is further shaped by removing or cutting away cancellous bone tissue to form a cancellous stalk extending from the cartilage plate. The formed cancellous stalk can have any suitable shape including cylindrical, conical, and rectilinear. At the recipient site of the host bone, a cutout is formed corresponding in shape to the allograft plug. The allograft plug is inserted into the cutout such that the cancellous stalk is retained in the host bone and the cartilage plate aligns with the condyle surface of the host bone. Aspects of the invention may also be applicable to preparing and transplanting osteochondral autograft plugs.
    Type: Application
    Filed: February 23, 2007
    Publication date: June 14, 2007
    Inventor: Theodore Malinin
  • Publication number: 20070135918
    Abstract: Provided are procedures and instruments for preparing and transplanting osteochondral allograft plugs to a host bone to repair an articular cartilage defect. An allograft bone plug having a cartilage plate and cancellous bone tissue attached thereto is removed from a donor bone. The allograft plug is further shaped by removing or cutting away cancellous bone tissue to form a cancellous stalk extending from the cartilage plate. The formed cancellous stalk can have any suitable shape including cylindrical, conical, and rectilinear. At the recipient site of the host bone, a cutout is forined corresponding in shape to the allograft plug. The allograft plug is inserted into the cutout such that the cancellous stalk is retained in the host bone and the cartilage plate aligns with the condyle surface of the host bone. Aspects of the invention may also be applicable to preparing and transplanting osteochondral autograft plugs.
    Type: Application
    Filed: February 23, 2007
    Publication date: June 14, 2007
    Inventor: Theodore Malinin
  • Publication number: 20070135917
    Abstract: Provided are procedures and instruments for preparing and transplanting osteochondral allograft plugs to a host bone to repair an articular cartilage defect. An allograft bone plug having a cartilage plate and cancellous bone tissue attached thereto is removed from a donor bone. The allograft plug is further shaped by removing or cutting away cancellous bone tissue to form a cancellous stalk extending from the cartilage plate. The formed cancellous stalk can have any suitable shape including cylindrical, conical, and rectilinear. At the recipient site of the host bone, a cutout is formed corresponding in shape to the allograft plug. The allograft plug is inserted into the cutout such that the cancellous stalk is retained in the host bone and the cartilage plate aligns with the condyle surface of the host bone. Aspects of the invention may also be applicable to preparing and transplanting osteochondral autograft plugs.
    Type: Application
    Filed: February 21, 2007
    Publication date: June 14, 2007
    Inventor: Theodore Malinin
  • Publication number: 20070098759
    Abstract: Disclosed is a method for regenerating articular cartilage in an animal comprising administering a therapeutically effective amount of a non-demineralized particulate articular cartilage having a distribution of particle sizes within the range of from about 60 microns to about 500 microns.
    Type: Application
    Filed: November 28, 2006
    Publication date: May 3, 2007
    Inventor: Theodore Malinin