Patents by Inventor Theodore Mitchell Klein
Theodore Mitchell Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11330776Abstract: The disclosure pertains to methods and compositions for the rapid and efficient transformation of plants. The disclosure further provides methods for producing a transgenic plant, comprising (a) transforming a cell of an explant with an expression construct comprising (i) a nucleotide sequence encoding a WUS/WOX homeobox polypeptide; (ii) a nucleotide sequence encoding a polypeptide comprising two AP2-DNA binding domains; or (iii) a combination of (i) and (ii); and (b) allowing expression of the polypeptide of (a) in each transformed cell to form a regenerable plant structure in the absence of exogenous cytokinin, wherein no callus is formed; and (c) germinating the regenerable plant structure to form the transgenic plant. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: GrantFiled: August 26, 2016Date of Patent: May 17, 2022Inventors: Ajith Anand, Maren L. Arling, Alexandre Da Silva Conceicao, William James Gordon-Kamm, Craig E Hastings, George J Hoerster, Todd J Jones, Theodore Mitchell Klein, Carlos M La Rota, Keith S Lowe, Shiv Bahadur Tiwari, Ning Wang, Xinli Emily Wu
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Patent number: 11104911Abstract: Compositions and methods for regulating expression of heterologous nucleotide sequences in a plant are provided. Compositions include nucleotide sequences for regulatory regions. Phospholipid transfer protein (PLTP) promoters from maize are provided. Also provided is a method for expressing a heterologous nucleotide sequence in a plant using a promoter sequence, such as a maize PLTP promoter, disclosed herein. DNA constructs comprising a promoter operably linked to a heterologous nucleotide sequence of interest are also provided.Type: GrantFiled: August 26, 2016Date of Patent: August 31, 2021Inventors: Alexandre Da Silva Conceicao, William James Gordon-Kamm, Theodore Mitchell Klein, Carlos M. La Rota, Keith S. Lowe
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Patent number: 10968458Abstract: Compositions and methods are provided for the introduction and the regulated expression of genes in plants. Compositions include promoter constructs that provide a level of activity useful for the regulated expression of site-specific recombinases, while avoiding premature excision. Further provided are isolated polynucleotides encoding novel babyboom polypeptides, expression cassettes, and plants comprising the same. Methods for the introduction of genes into plants are provided, including methods for plastid transformation and methods for the transformation of tissues from mature seeds and leaves.Type: GrantFiled: August 10, 2017Date of Patent: April 6, 2021Inventors: William James Gordon-Kamm, Theodore Mitchell Klein, Keith S. Lowe, Kevin E. McBride, Christopher Jay Scelonge, Ning Wang
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Publication number: 20190078106Abstract: The present disclosure provides methods and compositions for the vectors comprising vir genes. The present disclosure further provides a vector comprising: (a) an origin of replication for propagation and stable maintenance in Escherichia coli; (b) an origin of replication for propagation and stable maintenance in Agrobacterium spp.; (c) a selectable marker gene; and (d) Rhizobiaceae virulence genes virB1-B11 or r-virB1-B11, virC1-C2 or r-virC1-C2, virD1-D2 or r-virD1-D2, and virG or r-virG, or variants and derivatives thereof, wherein the vector comprising the virulence genes r-virB1-B11, r-virC1-C2, r-virD1-D2, and r-virG further comprises a r-galls virulence gene, or variants and derivatives thereof. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: ApplicationFiled: August 26, 2016Publication date: March 14, 2019Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: AJITH ANAND, STEVEN HENRY BASS, HYEON-JE CHO, THEODORE MITCHELL KLEIN, MICHAEL LASSNER, KEVIN E. MCBRIDE
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Publication number: 20170342431Abstract: Compositions and methods are provided for the introduction and the regulated expression of genes in plants. Compositions include promoter constructs that provide a level of activity useful for the regulated expression of site-specific recombinases, while avoiding premature excision. Further provided are isolated polynucleotides encoding novel babyboom polypeptides, expression cassettes, and plants comprising the same. Methods for the introduction of genes into plants are provided, including methods for plastid transformation and methods for the transformation of tissues from mature seeds and leaves.Type: ApplicationFiled: August 10, 2017Publication date: November 30, 2017Inventors: WILLIAM JAMES GORDON-KAMM, THEODORE MITCHELL KLEIN, KEITH S. LOWE, KEVIN E MCBRIDE, CHRISTOPHER JAY SCELONGE, NING WANG
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Patent number: 9765352Abstract: Compositions and methods are provided for the introduction and the regulated expression of genes in plants. Compositions include promoter constructs that provide a level of activity useful for the regulated expression of site-specific recombinases, while avoiding premature excision. Further provided are isolated polynucleotides encoding novel babyboom polypeptides, expression cassettes, and plants comprising the same. Methods for the introduction of genes into plants are provided, including methods for plastid transformation and methods for the transformation of tissues from mature seeds and leaves.Type: GrantFiled: November 22, 2013Date of Patent: September 19, 2017Assignees: E I DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.Inventors: William James Gordon-Kamm, Theodore Mitchell Klein, Keith S Lowe, Kevin E McBride, Christopher Jay Scelonge, Ning Wang
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Publication number: 20170121722Abstract: The disclosure pertains to methods and compositions for the rapid and efficient transformation of plants. The disclosure further provides methods for producing a transgenic plant, comprising (a) transforming a cell of an explant with an expression construct comprising (i) a nucleotide sequence encoding a WUS/WOX homeobox polypeptide; (ii) a nucleotide sequence encoding a polypeptide comprising two AP2-DNA binding domains; or (iii) a combination of (i) and (ii); and (b) allowing expression of the polypeptide of (a) in each transformed cell to form a regenerable plant structure in the absence of exogenous cytokinin, wherein no callus is formed; and (c) germinating the regenerable plant structure to form the transgenic plant. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: ApplicationFiled: August 26, 2016Publication date: May 4, 2017Applicant: PIONEER HI-BRED INTERNATIONAL, INC.Inventors: AJITH ANAND, MAREN L. ARLING, ALEXANDRE DA SILVA CONCEICAO, WILLIAM JAMES GORDON-KAMM, CRAIG E. HASTINGS, GEORGE M. HOERSTER, THEODORE MITCHELL KLEIN, CARLOS M. LA ROTA, KEITH S. LOWE, SHIV BAHADUR TIWARI, NING WANG, XINLI EMILY WU
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Publication number: 20140157453Abstract: Compositions and methods are provided for the introduction and the regulated expression of genes in plants. Compositions include promoter constructs that provide a level of activity useful for the regulated expression of site-specific recombinases, while avoiding premature excision. Further provided are isolated polynucleotides encoding novel babyboom polypeptides, expression cassettes, and plants comprising the same. Methods for the introduction of genes into plants are provided, including methods for plastid transformation and methods for the transformation of tissues from mature seeds and leaves.Type: ApplicationFiled: November 22, 2013Publication date: June 5, 2014Applicants: E.I. DUPONT DE NEMOURS, PIONEER HI BRED INTERNATIONAL INCInventors: WILLIAM JAMES GORDON-KAMM, THEODORE MITCHELL KLEIN, KEITH S. LOWE, KEVIN E. MCBRIDE, CHRISTOPHER JAY SCELONGE, NING WANG
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Publication number: 20140137291Abstract: This invention relates to an isolated nucleic acid fragment encoding a transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of accumulated oil in a transformed host cell.Type: ApplicationFiled: January 31, 2014Publication date: May 15, 2014Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: Rebecca E Cahoon, Theodore Mitchell Klein
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Patent number: 8692072Abstract: This invention relates to an isolated nucleic acid fragment encoding a transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of accumulated oil in a transformed host cell.Type: GrantFiled: May 30, 2013Date of Patent: April 8, 2014Assignee: E.I. du Pont de Nemours and CompanyInventors: Rebecca E Cahoon, Theodore Mitchell Klein
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Publication number: 20130276167Abstract: This invention relates to an isolated nucleic acid fragment encoding a transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of accumulated oil in a transformed host cell.Type: ApplicationFiled: May 30, 2013Publication date: October 17, 2013Inventors: Rebecca E. Cahoon, Theodore Mitchell Klein
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Patent number: 8466344Abstract: This invention relates to an isolated nucleic acid fragment encoding a transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of accumulated oil in a transformed host cell.Type: GrantFiled: September 14, 2012Date of Patent: June 18, 2013Assignee: E I du Pont de Nemours and CompanyInventors: Rebecca E Cahoon, Theodore Mitchell Klein
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Patent number: 8304608Abstract: This invention relates to an isolated nucleic acid fragment encoding a transcription factor. The invention also relates to the construction of a chimeric gene encoding all or a portion of the transcription factor, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of accumulated oil in a transformed host cell.Type: GrantFiled: December 16, 2010Date of Patent: November 6, 2012Assignee: E I du Pont de Nemours and CompanyInventors: Rebecca E. Cahoon, Theodore Mitchell Klein
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Publication number: 20090172842Abstract: The invention describes isolation and functional expression of RUBISCO genes derived from C4 plants and red algae in C3 plant hosts. Specifically the RUBISCO genes of Amaranthus edulis were functionally expressed at high levels in the transgenic crop plants soybean and tobacco, while the RUBISCO gene from Griffithsia monilis alga was expressed at lower levels in the transgenic crop tobacco.Type: ApplicationFiled: September 4, 2008Publication date: July 2, 2009Inventors: TIMOTHY CASPAR, Theodore Mitchell Klein, Min Qi, Jianjun Yang
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Publication number: 20090172832Abstract: The invention relates to a method for transformation of plant chloroplasts with genetic constructs by insertion of a RUBISCO gene in a non-RUBISCO site of the chloroplast genome to generate transformed plants that produce large amounts of a functional RUBISCO enzyme.Type: ApplicationFiled: September 4, 2008Publication date: July 2, 2009Inventors: TIMOTHY CASPAR, Theodore Mitchell Klein, Min Qi, Jianjun Yang