Abstract: The present invention is directed to compounds, compositions and methods for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus. Also within the scope of this invention are assay methods for identifying agents that modulate NS4B activity, as well as kits for performing such methods.

Abstract: The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.

Abstract: This invention relates to a novel process for making 3-O-(3?,3?-dimethylsuccinyl)betulinic acid (“DSB”). This invention also relates to methods of treating HIV and related diseases using pharmaceutical compositions comprising salt forms of DSB prepared according to the process of the present invention. The invention further relates to dosage forms of pharmaceutical compositions comprising salts of DSB made using the process of this invention.

Abstract: The present invention relates to novel synthetic derivatives of betulin and the use of such derivatives as pharmaceuticals. The present invention is directed to novel compounds of Formula I: or a pharmaceutically acceptable salt or prodrug thereof.

Abstract: The present invention relates to the use of pleconaril to reduce the contagion of rhinovirus virions shed from a host infected with a rhinovirus and thereby reduce disease transmission or re-infection.

Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.

Abstract: Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.

Abstract: Oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutically acceptable salts thereof, compositions comprising oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof and methods for using oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof as anti-picornaviral agents are described herein. The methods include using pleconaril as a prodrug for conversion to anti-picornaviral compounds in vivo.

Abstract: Oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutically acceptable salts thereof, compositions comprising oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof and methods for using oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof as anti-picornaviral agents are described herein.

Abstract: An improved control for an automatic transmission upshift, wherein the engine output torque and on-coming clutch pressure are coordinated during the shift based on an inverse dynamic model of the transmission to achieve a desired output torque trajectory. The desired output torque trajectory is influenced by operator demand, and an initial value of the desired output torque trajectory is used along with the engine output torque to develop an input acceleration trajectory. The inverse dynamic model of the transmission is used (1) to determine an engine torque command that will achieve both the input acceleration trajectory and the desired output torque trajectory, and (2) to determine a feed-forward pressure command for the on-coming clutch that will produce the input acceleration trajectory, given the engine torque command.

Abstract: Integration of vehicle speed and engine control functions in an automotive vehicle internal combustion engine controller compensates for mechanical lash between a cruise control actuator and an engine intake air valve without sacrificing control responsiveness through a parallel control approach, and improves overall control stability and controllability in the absence of mechanical lash through a selective control approach established to provide for smooth transitions between control modes. Improvement in the integration of deceleration fuel cutoff control with cruise control operates to prevent torque disturbances caused by control transitions in sensitive engine operating regions.