Patents by Inventor Theodore O. Johnson, Jr.

Theodore O. Johnson, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Patent number: 6995142
    Abstract: Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
    Type: Grant
    Filed: November 6, 2002
    Date of Patent: February 7, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson, Jr.
  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Patent number: 6989384
    Abstract: Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Grant
    Filed: July 23, 2003
    Date of Patent: January 24, 2006
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Ye Hua, Hiep The Luu, Fora P. Chan, Theodore O. Johnson, Jr., Siegfried Heinz Reich, Donald James Skalitzky, Yi Yang, Thomas F. Hendrickson, Shao Song Chu, Brian Walter Eastman
  • Antipicornaviral compounds, their preparation and use
    Patent number: 6906198
    Abstract: Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: June 14, 2005
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson, Jr., Jayashree Girish Tikhe
  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Patent number: 6872745
    Abstract: Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: March 29, 2005
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Theodore O. Johnson, Jr., Ye Hua, Hiep T. Luu, Peter S. Dragovich
  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Patent number: 6632825
    Abstract: Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: October 14, 2003
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Theodore O. Johnson, Jr., Shao Song Chu, Brian Walter Eastman, Ye Hua, Hiep The Luu, Siegfried Heinz Reich, Donald James Skalitzky, Yi Yang, Thomas F. Hendrickson, Fora P. Chan
  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Patent number: 6610730
    Abstract: Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also described.
    Type: Grant
    Filed: April 12, 2001
    Date of Patent: August 26, 2003
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Theodore O. Johnson Jr., Ye Hua, Hiep T. Luu, Peter S. Dragovich
  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Patent number: 6531452
    Abstract: Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds, are useful for treating patients or hosts infected with one or more picornaviruses, such as RVP. Intermediates and synthetic methods for preparing such compounds are also provided.
    Type: Grant
    Filed: April 29, 1999
    Date of Patent: March 11, 2003
    Assignee: Agouron Pharmaceuticals, Inc.
    Inventors: Peter Scott Dragovich, Stephen Evan Webber, Thomas Jay Prins, Ru Zhou, Joseph Timothy Marakovits, Theodore O. Johnson, Jr.
  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Publication number: 20020061916
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: June 13, 2001
    Publication date: May 23, 2002
    Inventors: Theodore O. Johnson, Jr., Shao Song Chu, Brian Walter Eastman, Ye Hua, Hiep The Luu, Siegfried Heinz Reich, Donald James Skalitzky, Yi Yang, Thomas F. Hendrickson, Fora P. Chan
  • Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis
    Publication number: 20020006943
    Abstract: Compounds of the formula: 1
    Type: Application
    Filed: April 12, 2001
    Publication date: January 17, 2002
    Inventors: Theodore O. Johnson , Jr., Ye Hua, Hiep T. Luu, Peter S. Dragovich
  • Hydroxy-amino acid amides
    Patent number: 5872262
    Abstract: Compounds of Formula I ##STR1## are disclosed as inhibitors of plasmepsin and cathepsin D. The compounds are therefore useful to treat diseases such as malaria. In preferred compounds of formula I, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. Intermediates in the solid phase synthesis of compounds of formula I, in which the compounds are attached to a solid support, are also disclosed.
    Type: Grant
    Filed: December 8, 1997
    Date of Patent: February 16, 1999
    Assignee: Pharmacopeia, Inc.
    Inventors: Roland Ellwood Dolle, III, Hitesh K. Patel, Theodore O. Johnson, Jr., Carolyn DiIanni Carroll, Shiwei Tao
  • Hydroxy-amino acid amides
    Patent number: 5734054
    Abstract: Compounds of Formula I ##STR1## are disclosed as inhibitors of plasmepsin and cathepsin D. The compounds are therefore useful to treat diseases such as malaria. In preferred compounds of formula I, Y is the residue of an N-acylated amino acid, a substituted 4-aminoproline or a substituted piperazinealkanoic acid. Intermediates in the solid phase synthesis of compounds of formula I, in which the compounds are attached to a solid support, are also disclosed.
    Type: Grant
    Filed: November 5, 1996
    Date of Patent: March 31, 1998
    Assignee: Pharmacopeia, Inc.
    Inventors: Roland Ellwood Dolle, III, Theodore O. Johnson, Jr., Carolyn DiIanni Carroll