Patents by Inventor Theodore Platt

Theodore Platt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250157570
    Abstract: In some aspects, the present disclosure provides a method for determining a polyamino acid descriptor associated with a biological state. The method can comprise removing technical variation from a proteomic dataset to generate a refined proteomic dataset, the technical variation arising from a predetermined non-biological factor, by training a neural network using a loss function. The loss function can be configured to increase a similarity between a first set of latent embeddings that are based on a first subset of polyamino acid descriptors in the proteomic dataset, wherein the first subset of polyamino acid descriptors are obtained from the same sample. The loss function can be configured to decrease the similarity between a second set of latent embeddings that are based on a second subset of polyamino acid descriptors in the proteomic dataset, wherein the second subset of polyamino acid descriptors are obtained from different samples.
    Type: Application
    Filed: February 15, 2023
    Publication date: May 15, 2025
    Inventors: Theodore Platt, Iman Mohtashemi, Hugo Kitano, Asim Siddiqui, Amir ALAVI, Harendra GUTURU
  • Patent number: 12287331
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Grant
    Filed: September 1, 2023
    Date of Patent: April 29, 2025
    Assignee: Seer, Inc.
    Inventors: Hongwei Xia, Lyndal Hesterberg, Michael Figa, Xiaoyan Zhao, Gregory Troiano, William Manning, John Blume, Omid Farokhzad, Matthew McLean, Craig Stolarczyk, Marwin Ko, Theodore Platt
  • Patent number: 12276668
    Abstract: Disclosed herein are compositions and methods for assaying for proteins and nucleic acids, in parallel.
    Type: Grant
    Filed: February 24, 2023
    Date of Patent: April 15, 2025
    Assignee: Seer, Inc.
    Inventors: Daniel Hornburg, Michael Figa, Xiaoyan Zhao, Asim S. Siddiqui, Philip Ma, Sangtae Kim, Omid C. Farokhzad, Margaret Donovan, John E. Blume, Theodore Platt, Martin Goldberg, Damian Harris
  • Patent number: 12222349
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: February 11, 2025
    Assignee: Seer, Inc.
    Inventors: Hongwei Xia, Lyndal Hesterberg, Michael Figa, Xiaoyan Zhao, Gregory Troiano, William Manning, John Blume, Omid Farokhzad, Matthew McLean, Craig Stolarczyk, Marwin Ko, Theodore Platt
  • Publication number: 20240385156
    Abstract: The present disclosure describes methods and systems for analyzing mass spectrometry data. The methods and systems can comprise an operation of contacting a plurality of biomolecules with a plurality of surfaces. The methods and systems can further comprise performing mass spectrometry on the plurality of biomolecules, or a portion or derivative thereof. The methods and systems can further comprise classifying a sample based on the mass spectra. The methods and systems of the disclosure may be used for identifying evidence of operational errors in mass spectrometry datasets.
    Type: Application
    Filed: May 16, 2023
    Publication date: November 21, 2024
    Inventors: Biao LI, Ryan BENZ, Harendra GUTURU, Iman MOHTASHEMI, Theodore PLATT, Serafim BATZOGLOU
  • Publication number: 20240353419
    Abstract: Disclosed herein are particles and methods of using said particles in assays for detection of biomolecules in a sample. Various methods of the present disclosure utilize particles for biomolecule adsorption. In some aspects, the present disclosure provides methods which utilize multiple particle concentrations to differentially fractionate biological samples. In further aspects, the present disclosure provides methods which utilize low particle concentrations to enhance adsorbed biomolecule diversity.
    Type: Application
    Filed: July 3, 2024
    Publication date: October 24, 2024
    Inventors: Omid C. FAROKHZAD, Craig STOLARCZYK, John E. BLUME, Xiaoyan ZHAO, Martin GOLDBERG, Michael FIGA, Asim SIDDIQUI, Daniel HORNBURG, Damian HARRIS, Philip MA, Theodore PLATT, Shadi ROSHDIFERDOSI
  • Publication number: 20240280558
    Abstract: In some aspects, the present disclosure provides a method for normalizing and processing mass spectrometry datasets. In some embodiments, the method comprises loading a plurality of mass spectrometry data obtained from a plurality of samples into a memory of a computing node to generate a cached dataset. In some embodiments, the method comprises transmitting a copy of the cached dataset to a plurality of cache memories of a plurality of computing nodes. In some embodiments, the method comprises determining, using the plurality of computing nodes, a plurality of feature values for the plurality of mass spectrometry data. In some embodiments, the method comprises normalizing, using the plurality of computing nodes, across the plurality of mass spectrometry datasets using the plurality of feature values to generate a plurality of normalized mass spectrometry data.
    Type: Application
    Filed: July 13, 2022
    Publication date: August 22, 2024
    Inventors: Theodore Platt, Iman Mohtashemi, Hugo Kitano, Asim Siddiqui
  • Publication number: 20230417744
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Application
    Filed: September 1, 2023
    Publication date: December 28, 2023
    Inventors: Hongwei XIA, Lyndal HESTERBERG, Michael FIGA, Xiaoyan ZHAO, Gregory TROIANO, William MANNING, John BLUME, Omid FAROKHZAD, Matthew MCLEAN, Craig STOLARCZYK, Marwin KO, Theodore Platt
  • Publication number: 20230408503
    Abstract: Disclosed herein are compositions and methods for assaying for proteins and nucleic acids, in parallel.
    Type: Application
    Filed: February 24, 2023
    Publication date: December 21, 2023
    Inventors: Daniel HORNBURG, Michael FIGA, Xiaoyan ZHAO, Asim S. SIDDIQUI, Philip MA, Sangtae KIM, Omid C. FAROKHZAD, Margaret DONOVAN, John E. BLUME, Theodore PLATT, Martin GOLDBERG, Damian HARRIS
  • Publication number: 20230324401
    Abstract: Disclosed herein are particles and methods of using said particles in assays for detection of biomolecules in a sample. Various methods of the present disclosure utilize particles for biomolecule adsorption. In some aspects, the present disclosure provides methods which utilize multiple particle concentrations to differentially fractionate biological samples. In further aspects, the present disclosure provides methods which utilize low particle concentrations to enhance adsorbed biomolecule diversity.
    Type: Application
    Filed: July 19, 2021
    Publication date: October 12, 2023
    Inventors: Omid C. FAROKHZAD, Craig STOLARCZYK, John E. BLUME, Xiaoyan ZHAO, Martin GOLDBERG, Michael FIGA, Asim SIDDIQUI, Daniel HORNBURG, Damian HARRIS, Philip MA, Theodore PLATT, Shadi ROSHDIFERDOSI
  • Publication number: 20230160882
    Abstract: Disclosed herein are compositions and methods for assaying for low volumes of proteins and/or nucleic acids, optionally in parallel.
    Type: Application
    Filed: August 24, 2022
    Publication date: May 25, 2023
    Inventors: Asim Sarosh SIDDIQUI, Philip MA, Sangtae KIM, Omid FAROKHZAD, Margaret DONOVAN, John BLUME, Khatereh MOTAMEDCHABOKI, Daniel HORNBURG, Theodore PLATT, Martin GOLDBERG, Damian HARRIS, Michael FIGA, Xiaoyan ZHAO
  • Patent number: 11428688
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Grant
    Filed: March 29, 2021
    Date of Patent: August 30, 2022
    Assignee: SEER, INC.
    Inventors: Hongwei Xia, Lyndal Hesterberg, Michael Figa, Xiaoyan Zhao, Gregory Troiano, William Manning, John Blume, Omid Farokhzad, Matthew McLean, Craig Stolarczyk, Marwin Ko, Theodore Platt
  • Publication number: 20210285957
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 16, 2021
    Inventors: Hongwei XIA, Lyndal HESTERBERG, Michael FIGA, Xiaoyan ZHAO, Gregory TROIANO, William MANNING, John BLUME, Omid FAROKHZAD, Matthew MCLEAN, Craig STOLARCZYK, Marwin KO, Theodore Platt
  • Publication number: 20210215685
    Abstract: Compositions, methods, and systems for analyzing the protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic targets.
    Type: Application
    Filed: March 29, 2021
    Publication date: July 15, 2021
    Inventors: Hongwei XIA, Lyndal HESTERBERG, Michael FIGA, Xiaoyan ZHAO, Gregory TROIANO, William MANNING, John BLUME, Omid FAROKHZAD, Matthew MCLEAN, Craig STOLARCZYK, Marwin KO, Theodore Platt