Abstract: Methods of analyzing a biological fluid to determine an expected therapeutic benefit of the fluid include determining amounts of components within the biological fluid. Comparisons of a first component of the biological fluid relative to another component of the biological are made to characterize a therapeutic effect of the biological fluid.

Abstract: The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component and/or a 3D-printed implantable device. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.

Abstract: The invention is directed to a device for the concentration of fluids comprising a donor receptacle containing a fluid to be concentrated, the donor receptacle comprising a plunger; a receiving receptacle to receive the concentrated fluid, the receiving receptacle comprising a plunger; a concentrator device that is connected to the donor receptacle and the receiving receptacle; and a housing that encloses the donor and receiving receptacles and the concentrator device that the plungers of the donor and receiving receptacles are enclosed within chambers that are gas tight.

Abstract: The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.

Abstract: Methods of analyzing a biological fluid to determine an expected therapeutic benefit of the fluid include determining amounts of components within the biological fluid. Comparisons of a first component of the biological fluid relative to another component of the biological are made to characterize a therapeutic effect of the biological fluid.

Abstract: An autologous cell concentrating system and method are disclosed. The system has a blood separation component, a first vessel, a second vessel, a first valve, a second valve, and a concentration and flow logic and control component. The concentration and flow logic and control component is configured to: determine a first volume of a target cell-poor fraction in the first vessel to mix with a target cell-rich fraction in the second vessel in order to form a target cell-rich concentrate having a concentration of target cells that is within a target concentration range; and control the second valve to transfer the first volume of the target cell-rich fraction from the first vessel to the second vessel to form the target cell-rich concentrate. The target concentration range is between 1.0 and 1.5×106 target platelets/?L.

Abstract: A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged within a resorbable mesh casing.

Abstract: Embodiments of the invention is directed to methods of forming a bone-like material, by placing a matrix into a culture container, adding cells to the matrix, placing the tissue-cell construct into the culturing environment and incubating the construct under appropriate conditions for the time required to produce an amount of bone-like material of sufficient volume to be harvested for further processing. Other embodiments of the invention are directed to the use of the bone-like material formed by methods of the invention in implantation procedures.

Abstract: The invention comprises a combination of biological elements that will naturally remodel in vivo based on applied mechanical forces. The final composition will possess mechanical properties similar to cartilage or a disc, and significantly less stiff than bone or implants comprised of metals or plastics. The equilibrium stress conduction will minimize unnatural forces on neighboring healthy discs.

Abstract: A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged within a resorbable mesh casing.

Abstract: The invention is directed to a work station for use in performing processing of patient samples, storing equipment and drugs in a hospital and the like, the cart having a lower housing having caster wheels mounted on the bottom thereof, the lower housing having angular-shaped side panels therearound which may be opened for entrance into all sides of the housing, and one or more of the side panels; an upper housing mounted on top of the lower housing, the upper housing having one or more side panels therearound; and one or more work areas mounted on top of the upper housing, the shelf adapted for receiving point-of-care equipment.

Abstract: The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component and/or a 3D-printed implantable device. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.

Abstract: The invention is directed to a therapeutic composition that includes a first cell preparation that includes isolated stromal cells of a first type and a second cell preparation that includes isolated stromal cells of a second type. The first and second cell preparations may include cultured cells. The stromal cells may include adipose stromal cells and bone marrow derived stromal cells. The therapeutic composition may include a blood component that includes one or more of platelet-poor plasma, concentrated platelet-poor plasma, platelet-rich plasma, and whole blood.

Abstract: The invention is directed to a method for isolating stromal cells to form a therapeutic composition; and administering said therapeutic composition to the subject. A further embodiment of the invention is directed to therapeutic compositions comprising isolated stromal cells.

Abstract: The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.

Abstract: A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged within a resorbable mesh casing.

Abstract: The invention is directed to a method for therapeutic repair of an injury to bone or tissue comprising providing a structural component, wherein the structural component repairs the injury; and providing a therapeutic fluid, wherein the therapeutic fluid is located within the structural component.

Abstract: The invention is directed to a device for the concentration of fluids comprising a donor receptacle containing a fluid to be concentrated, the donor receptacle comprising a plunger; a receiving receptacle to receive the concentrated fluid, the receiving receptacle comprising a plunger; a concentrator device that is connected to the donor receptacle and the receiving receptacle; and a housing that encloses the donor and receiving receptacles and the concentrator device that the plungers of the donor and receiving receptacles are enclosed within chambers that are gas tight.

Abstract: The invention comprises a combination of biological elements that will naturally remodel in vivo based on applied mechanical forces. The final composition will possess mechanical properties similar to cartilage or a disc, and significantly less stiff than bone or implants comprised of metals or plastics. The equilibrium stress conduction will minimize unnatural forces on neighboring healthy discs.

Abstract: The invention is directed to a work station for use in performing processing of patient samples, storing equipment and drugs in a hospital and the like, the cart having a lower housing having caster wheels mounted on the bottom thereof, the lower housing having angular-shaped side panels therearound which may be opened for entrance into all sides of the housing, and one or more of the side panels; an upper housing mounted on top of the lower housing, the upper housing having one or more side panels therearound; and one or more work areas mounted on top of the upper housing, the shelf adapted for receiving point-of-care equipment.