Abstract: Methods for treating a cancer (such as, e.g., acute myeloid leukemia) comprising administering to a subject (such as, e.g., a subject who has acquired resistance to a therapy comprising at least one antineoplastic agent and/or at least one hypomethylating agent) at least one E-selectin antagonist, wherein the subject is further administered at least one antineoplastic agent (such as, e.g., venetoclax) and/or at least one hypomethylating agent are disclosed.

Abstract: The present disclosure relates to compositions and methods for nucleic acid sequencing, and specifically, at least in certain aspects, provides methods and compositions for enhancing the efficacy, throughput and/or yield of known long-range sequencing platforms, by providing chimeric arrays of input sequences. Such arrays of component nucleic acid sequence elements can be prepared via methods that minimize introduction of bias. The application of the current methods to obtain isoform sequencing information, e.g., from patient samples is specifically also provided, as are methods for mitochondrial lineage tracing that employ the instant chimeric amplicon sequencing processes. Methods and systems for array nucleic acid sequence processing and interpretation are also provided.

Abstract: Methods for treating a cancer (such as, e.g., acute myeloid leukemia) comprising administering to a subject (such as, e.g., a subject who has acquired resistance to a therapy comprising at least one antineoplastic agent and/or at least one hypomethylating agent) at least one E-selectin antagonist, wherein the subject is further administered at least one antineoplastic agent (such as, e.g., venetoclax) and/or at least one hypomethylating agent are disclosed.

Abstract: Method and system for storing and/or transporting temperature-sensitive materials. In one embodiment, the system is designed to keep a payload within a desired temperature range of +2° C. to +8° C. for an extended time in a warm ambient environment. The system includes a thermally insulated container and first and second phase-change materials, each of the phase-change materials having a different solid/liquid phase-change temperature. Both phase-change materials are preconditioned to a solid state for pack-out. The first phase-change material has a solid/liquid phase-change temperature that is within the desired temperature range and that is at or below a hibernation temperature of about +5° C. to +6° C. The second phase-change material has a solid/liquid phase-change temperature that is above the hibernation temperature.

Abstract: A system and method are for analyzing fluorescence of fluorophors in an eye using a non-negative matrix factorization (NMF) method. The NMF method may be initialized with Gaussian mixture model fits and may optionally be constrained to provide identical abundance images for data obtained in response to two or more excitation wavelengths.

Abstract: Shipping system for temperature-sensitive materials. In one embodiment, the shipping system may include a frame defining an enclosure. The frame may include a bottom, a top, a front, a rear, a left side, a right side, a left corner gusset, and a right corner gusset. The front may serve as a door. Thermal breaks may be provided in one or more of the bottom, the front, the left corner gusset, and the right corner gusset. Vacuum insulated panels may be positioned along all sides of the frame. Many of the vacuum insulated panels may be encapsulated between the frame and an outer shell. A plurality of phase-change material assemblies may be positioned within the frame along all sides. Heat-spreaders may be positioned interior to the phase-change material assemblies. The shipping system may be dimensioned so that four such shipping systems may be seated on a prorate manual cargo sheet.

Abstract: A system and method for in vivo detection and quantification of drusen present in the retina via administering an excitation signal to the retina of the eye and detecting an electromagnetic emissions spectrum from the retina in response to the excitation signal. The electromagnetic emissions spectrum may be used to identify a plurality of component emissions spectra, each component emissions spectrum corresponding to fluorescence from a component of the retina, one of the component emissions spectra corresponding to a target emissions spectrum.

Abstract: The present technology relates to a method of reducing seizure frequency in a subject having epilepsy by transdermally administering an effective amount of cannabidiol (CBD) to the subject wherein the seizure frequency is reduced.

Abstract: Cortical entrainment device (CED) and associated methods are provided. The CED device includes an electroencephalographic (EEG) analysis module configured to receive and process an EEG waveform for analyzing brain activity of a patient with epilepsy or a seizure disorder; an interictal epileptiform discharge (IED) analysis module configured to receive and process an IED waveform for analyzing the brain activity of the patient; and a diagnostic module that is configured to interface with the EEG analysis module and the IED analysis module, to evaluate spectral and temporal waveform characteristics, and to provide instructions to a therapy module for providing a stimulus for the patient based on the analysis by the EEG analysis module and the IED analysis module.

Abstract: A system and method for in vivo detection and quantification of drusen present in the retina via administering an excitation signal to the retina of the eye and detecting an electromagnetic emissions spectrum from the retina in response to the excitation signal. The electromagnetic emissions spectrum may be used to identify a plurality of component emissions spectra, each component emissions spectrum corresponding to fluorescence from a component of the retina, one of the component emissions spectra corresponding to a target emissions spectrum.

Abstract: A system and method are for analyzing fluorescence of fluorophors in an eye using a non-negative matrix factorization (NMF) method. The NMF method may be initialized with Gaussian mixture model fits and may optionally be constrained to provide identical abundance images for data obtained in response to two or more excitation wavelengths.

Abstract: Exemplary embodiments of the present disclosure can provide a retinal camera. The exemplary camera can include a body, at least one optical sensor which is (i) provided on the body, and (ii) configured to receive light directly from a lens of an eye, and a processing arrangement configured to generate an image based on the light received directly from the lens of the eye.

Abstract: The invention is directed to methods of treating patients suffering from Peyronie's disease, methods of identifying patients suffering from Peyronie's disease and a computer program for identifying patients suffering from Peyronie's disease.

Abstract: This invention provides a method of leveling an image of a non-uniform background. The method uses all or a portion of the image data from the original image and mathematical algorithms to construct a model image that reflects the non-uniform background of the original image and subtract the model image from the original image to generate an image with a more uniform background. This invention also provides computer software for performing the methods of the invention.

Abstract: In a design methodology for an electronic device that accepts a removable accessory card, the electronic device is provided with an accessory card receptacle and a power connector. The power connector is positioned with respect to the accessory card receptacle such that an accessory card cannot be inserted into, or removed from, the accessory card receptacle while a power cord is connected to the power connector. An accessory card, and electronic devices that receive accessory cards, are also disclosed.

Abstract: In a design methodology for an electronic device that accepts a removable accessory card, the electronic device is provided with an accessory card receptacle and a power connector. The power connector is positioned with respect to the accessory card receptacle such that an accessory card cannot be inserted into, or removed from, the accessory card receptacle while a power cord is connected to the power connector. An accessory card, and electronic devices that receive accessory cards, are also disclosed.

Abstract: Provided are adenoviral vectors and the production of such vectors. In particular, fiber shaft modifications for efficient targeting of adenoviral vectors are provided. The fiber shaft modifications can be combined with other modifications, such as fiber knob and/or penton modifications, to produce fully ablated (detargeted) adenoviral vectors. A scale-up method for the propagation of detargeted adenoviral vectors is also provided.

Abstract: Provided are adenoviral vectors and the production of such vectors. In particular, fiber shaft modifications for efficient targeting of adenoviral vectors are provided. The fiber shaft modifications can be combined with other modifications, such as fiber knob and/or penton modifications, to produce fully ablated (detargeted) adenoviral vectors. A scale-up method for the propagation of detargeted adenoviral vectors is also provided.

Abstract: An adenoviral vector including at least one DNA sequence encoding a clotting factor, such as, for example, Factor VIII, or Factor IX. Such vectors may be administered to a host in an amount effective to treat hemophilia in the host. The vectors infect hepatocytes very efficiently, whereby the hepatocytes express the DNA sequence encoding the clotting factor.

Abstract: An information storage device (10) includes a cartridge (14) removably inserted into a cradle (13) that has a drive module (18) releasably coupled to an interface module (17). The interface module can be operatively coupled by a cable (12) to a remote system. Communications through the cable conform to an industry-standard protocol. The storage device can receive power from either the cable or an external power source (31). The interface module can detect a change in the source of its operating power during normal system operation, and ensure that this is reported through the cable.