Abstract: A system and/or method uses a trained U-Net neural network to remove flow artifacts from optical coherence tomography (OCT) angiography (OCTA) data. The trained U-Net receives as input both OCT structural volume data and OCTA volume data, but expands the OCTA volume data to include depth information. The U-Net applies dynamic pooling along the depth direction and weighs more heavily the portion of the data that follows (e.g., along the contours of) select retinal layers. In this manner the U-Net applies contextually different computations at different axial locations based at least in part on the depth index information and/or (e.g., proximity to) the select retinal layers. The U-net outputs OCT volume data of reduced flow artifacts as compared with the input OCTA data.