Patents by Inventor Theodore T. Kramer

Theodore T. Kramer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterophil-adapted poultry vaccine
    Patent number: 6376228
    Abstract: A method for vaccinating poultry to prevent salmonellosis and other microbial-related health problems in humans is described. The method involves isolation of a poultry heterophil-adapted strain of a microorganism that may be used in a vaccine. A vaccine comprising a preparation of the poultry heterophil-adapted strain is administered to poultry to reduce the transmission of microorganisms causing salmonellosis and other illnesses.
    Type: Grant
    Filed: May 23, 2000
    Date of Patent: April 23, 2002
    Assignee: Iowa State University Research Foundation, Inc.
    Inventor: Theodore T. Kramer
  • Heterophil-adapted poultry vaccine
    Patent number: 6120774
    Abstract: A method for vaccinating poultry to prevent salmonellosis and other microbial-related health problems in humans is described. The method involves isolation of a poultry heterophil-adapted strain of a microorganism that may be used in a vaccine. A vaccine comprising a preparation of the poultry heterophil-adapted strain is administered to poultry to reduce the transmission of microorganisms causing salmonellosis and other illnesses.
    Type: Grant
    Filed: February 14, 1997
    Date of Patent: September 19, 2000
    Assignee: Iowa State University Research Foundation, Inc.
    Inventor: Theodore T. Kramer
  • Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals
    Patent number: 5580557
    Abstract: Disclosed herein are methods for attenuating virulent gram negative bacteria to produce avirulent bacteria. The methods comprise passaging the wild-type bacteria through phagocytic cells, such as macrophages or polymorphonuclear leukocytes, or through lysosomes derived from such cells, a sufficient number of times until the bacteria become avirulent to the animal host. The bacteria are preferably from the family Enterobacteracea and most preferably from the genus Salmonellae. The invention further comprises the avirulent bacteria produced by the methods, pure cultures of such bacteria, and methods of using the bacteria, preferably in a vaccine for administration to an animal host to induce an immune response to the wild-type gram negative bacteria in the host.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: December 3, 1996
    Assignee: Iowa State University Research Foundation, Inc.
    Inventor: Theodore T. Kramer
  • Live, avirulent Salmonella choleraesuis vaccine used for inducing an immune response in pigs
    Patent number: 5436001
    Abstract: Disclosed herein are methods for attenuating virulent gram negative bacteria to produce avirulent bacteria. The methods comprise passaging the wild-type bacteria through phagocytic cells, such as macrophages or polymorphonuclear leukocytes, or through lysosomes derived from such cells, a sufficient number of times until the bacteria become avirulent to the animal host. The bacteria are preferably from the family Enterobacteracea and most preferably from the genus Salmonellae. The invention further comprises the avirulent bacteria produced by the methods, pure cultures of such bacteria, and methods of using the bacteria, preferably in a vaccine for administration to an animal host to induce an immune response to the wild-type gram negative bacteria in the host.
    Type: Grant
    Filed: July 19, 1993
    Date of Patent: July 25, 1995
    Assignee: Iowa State University Research Foundation
    Inventor: Theodore T. Kramer