Patents by Inventor Theodore Tselios

Theodore Tselios has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide analogues of myelin basic protein epitopes in the treatment of experimental autoimmune encephalomyelitis (eae) and multiple sclerosis (ms)
    Publication number: 20040072222
    Abstract: This invention relates to novel linear and cyclic peptide analogues of Myclin Basic Protein epitopes (from guinea pig MBP72-85 and human MBP87-99) and their conjugates with mannan and/or KLH useful in the treatment of Experimental Autoimmune Encephalomyclitis (EAE) and Multiple Sclerosis (MS). For the first time cyclic analogues of MBP epitopes have been synthesized and shown to prevent the development of EAE. There is gathering evidence that analogues of disease-associated epitopes can be conjugated to mannan and/or KLH and actively generate antigen specific regulatory CD4/CD8 T cells and Th1/Th2 cytokines.
    Type: Application
    Filed: August 11, 2003
    Publication date: April 15, 2004
    Inventors: John Matsoukas, Vasso Apostolopoulos, Theodore Tselios