Patents by Inventor Theodore Widlanski

Theodore Widlanski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • &ggr;-phosphoester nucleoside triphosphates
    Patent number: 6399335
    Abstract: The invention provides methods and compositions for polymerizing a particular nucleotide with a polymerase. In general, the method involves (a) forming a mixture of a polymerase and a nucleoside triphosphate (NTP) comprising &agr;, &bgr; and &ggr; phosphates and a &ggr;-phosphate phosphoester-linked functional group; and incubating the mixture under conditions wherein the polymerase catalyzes cleavage of the NTP between the &agr; and &bgr; phosphates, liberating a pyrophosphate comprising the functional group and polymerizing the resultant nucleoside monophosphate, i.e. incorporates the nucleoside monophosphate in a nascent polynucleotide. A variety of functional groups compatible with the polymerization reaction are provided.
    Type: Grant
    Filed: November 16, 1999
    Date of Patent: June 4, 2002
    Assignee: Advanced Research and Technology Institute, Inc.
    Inventors: C. Cheng Kao, Theodore Widlanski, William Vassiliou, Jeffrey Epp