Patents by Inventor Theodorus Adrianus Cornelius Flipsen
Theodorus Adrianus Cornelius Flipsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11911524Abstract: The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O—groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.Type: GrantFiled: September 8, 2021Date of Patent: February 27, 2024Assignee: Stryker European Operations Holdings LLCInventors: Catharina Everdina Hissink, Theodorus Adrianus Cornelius Flipsen, Johan Zuidema, Linda Joan Gibcus
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Publication number: 20220313598Abstract: The invention relates to the fields of microbiology and health care, in particular to means and methods for minimizing the spread of hospital-acquired (HA) infections e.g. between patients and healthcare workers. Provided is an antimicrobial composition comprising an antimicrobial agent, a pharmaceutically acceptable carrier material and a polymer, the polymer being an N-vinyl lactam copolymer, and the composition being capable of forming a slow release antimicrobial film when applied to a skin surface.Type: ApplicationFiled: March 11, 2022Publication date: October 6, 2022Inventors: Joke Geesje Hagting, Theodorus Adrianus Cornelius Flipsen, Herbert Wilhelm Ulmer
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Patent number: 11291625Abstract: The invention relates to the fields of microbiology and health care, in particular to means and methods for minimizing the spread of hospital-acquired (HA) infections e.g. between patients and healthcare workers. Provided is an antimicrobial composition comprising an antimicrobial agent, a pharmaceutically acceptable carrier material and a polymer, the polymer being an N-vinyl lactam copolymer, and the composition being capable of forming a slow release antimicrobial film when applied to a skin surface.Type: GrantFiled: May 6, 2016Date of Patent: April 5, 2022Assignee: PolyVation B.V.Inventors: Joke Geesje Hagting, Theodorus Adrianus Cornelius Flipsen, Herbert Wilhelm Ulmer
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Publication number: 20210402047Abstract: The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O—groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.Type: ApplicationFiled: September 8, 2021Publication date: December 30, 2021Applicant: Stryker European Operations Holdings LLCInventors: Catharina Everdina Hissink, Theodorus Adrianus Cornelius Flipsen, Johan Zuidema, Linda Joan Gibcus
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Patent number: 11147898Abstract: The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O— groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.Type: GrantFiled: November 8, 2019Date of Patent: October 19, 2021Assignee: STRYKER EUROPEAN OPERATIONS HOLDINGS LLCInventors: Catharina Everdina Hissink, Theodorus Adrianus Cornelius Flipsen, Johan Zuidema, Linda Joan Gibcus
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Patent number: 11066502Abstract: The invention relates to copolymers of vinyl lactams with derivatized maleates. In particular, it relates to copolymers that are suitably used in the area of personal care and pharmaceuticals, to compositions comprising the copolymers and to methods for preparing the copolymers.Type: GrantFiled: July 2, 2009Date of Patent: July 20, 2021Assignee: PolyVation Cosmeterials B.V.Inventors: Herbert Wilhelm Ulmer, Theodorus Adrianus Cornelius Flipsen
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Publication number: 20200069835Abstract: The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O— groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.Type: ApplicationFiled: November 8, 2019Publication date: March 5, 2020Applicant: Stryker European Holdings I, LLCInventors: Catharina Everdina Hissink, Theodorus Adrianus Cornelius Flipsen, Johan Zuidema, Linda Joan Gibcus
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Patent number: 10508200Abstract: A composition including a) 55-98.9 wt % of at least one type of triblock copolymer (A) of formula (1) R—B-A-B—R??(1) b) 0.1-15 wt % of at least one surfactant (B) and c) 1-30 wt % of water, wherein A is a hydrophilic block having a number average molecular weight (Mn) of 100-1,000 Da, B is a hydrophobic block made from monomers having at least a monomer B1 and a monomer B2, wherein B1 and B2 have the largest weight contents in the hydrophobic block and B1 has a lower molecular weight than B2, wherein R is an end group which is H or a C1-C30 organic moiety, wherein the composition is fluid in a temperature range of 0° C. to 37° C., wherein the weight % are relative to the sum of a), b) and c), and wherein the sum of components a), b) and c) is at least 80 wt % of the entire composition, preferably at least 90 wt %; to the use of the composition and to pharmaceutical compositions having said composition and an active pharmaceutical ingredient.Type: GrantFiled: November 4, 2016Date of Patent: December 17, 2019Assignee: INGELL TECHNOLOGIES HOLDING B.V.Inventors: Ronald Meijboom, Paul Marcel Van Midwoud, Maarten Van Dijk, Theodorus Adrianus Cornelius Flipsen, Esther De Boef
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Patent number: 10507260Abstract: The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O— groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.Type: GrantFiled: April 24, 2015Date of Patent: December 17, 2019Assignee: Stryker European Holdings I, LLCInventors: Catharina Everdina Hissink, Theodorus Adrianus Cornelius Flipsen, Johan Zuidema, Linda Joan Gibcus
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Publication number: 20190211206Abstract: A composition including a) 55-98.9 wt % of at least one type of triblock copolymer (A) of formula (1) R—B-A-B—R ??(1) b) 0.1-15 wt % of at least one surfactant (B) and c) 1-30 wt % of water, wherein A is a hydrophilic block having a number average molecular weight (Mn) of 100-1,000 Da, B is a hydrophobic block made from monomers having at least a monomer B1 and a monomer B2, wherein B1 and B2 have the largest weight contents in the hydrophobic block and B1 has a lower molecular weight than B2, wherein R is an end group which is H or a C1-C30 organic moiety, wherein the composition is fluid in a temperature range of 0° C. to 37° C., wherein the weight % are relative to the sum of a), b) and c), and wherein the sum of components a), b) and c) is at least 80 wt % of the entire composition, preferably at least 90 wt %; to the use of the composition and to pharmaceutical composiitons having said composition and an active pharmaceutical ingredient.Type: ApplicationFiled: November 4, 2016Publication date: July 11, 2019Inventors: Ronald MEIJBOOM, Paul Marcel VAN MIDWOUD, Maarten VAN DIJK, Theodorus Adrianus Cornelius FLIPSEN, Esther DE BOEF
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Patent number: 10300019Abstract: This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterized in that: a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment, b) said multi-block copolymer having a Tg of 37° C. or less and a Tm of 110-250° C. under physiological conditions; c) the segments are linked by a multifunctional chain-extender; d) the segments are randomly distributed over the polymer chain; e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer.Type: GrantFiled: August 15, 2017Date of Patent: May 28, 2019Assignee: InnoCore Technologies B.V.Inventors: Rob Steendam, Theodorus Adrianus Cornelius Flipsen, Christine Hiemstra, Johan Zuidema
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Publication number: 20180147137Abstract: The invention relates to the fields of microbiology and health care, in particular to means and methods for minimizing the spread of hospital-acquired (HA) infections e.g. between patients and healthcare workers. Provided is an antimicrobial composition comprising an antimicrobial agent, a pharmaceutically acceptable carrier material and a polymer, the polymer being an N-vinyl lactam copolymer, and the composition being capable of forming a slow release antimicrobial film when applied to a skin surface.Type: ApplicationFiled: May 6, 2016Publication date: May 31, 2018Inventors: Joke Geesje HAGTING, Theodorus Adrianus Cornelius FLIPSEN, Herbert Wilhelm ULMER
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Publication number: 20180085318Abstract: This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterised in that: a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment, b) said multi-block copolymer having a Tg of 37° C. or less and a Tm of 110-250° C. under physiological conditions; c) the segments are linked by a multifunctional chain-extender; d) the segments are randomly distributed over the polymer chain; e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer.Type: ApplicationFiled: August 15, 2017Publication date: March 29, 2018Applicant: InnoCore Technologies B.V.Inventors: Rob STEENDAM, Theodorus Adrianus Cornelius FLIPSEN, Christine HIEMSTRA, Johan ZUIDEMA
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Patent number: 9610377Abstract: The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used, e.g., in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer comprises —C(O)—O— groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.Type: GrantFiled: July 8, 2005Date of Patent: April 4, 2017Assignee: STRYKER EUROPEAN HOLDINGS I, LLCInventors: Catharina Everdina Hissink, Theodorus Adrianus Cornelius Flipsen, Johan Zuidema, Linda Joan Gibcus
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Patent number: 9364442Abstract: The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. Provided is a composition for the controlled release of at least one biologically active polypeptide to a host, comprising the at least one biologically active polypeptide encapsulated in a matrix comprising at least one phase separated, thermoplastic multi-block copolymer, the copolymer being characterized in that (i) it comprises at least two hydrolysable segments chosen from prepolymer (A) and prepolymer (B), prepolymer (A) having a Tg lower than 37° C. and prepolymer (B) having a Tm of 40° C.-100° C. under physiological conditions; (ii) the segments being linked by a multifunctional chain-extender; (iii) the segments are randomly distributed over the polymer chain; and (iv) prepolymer (A) contains a segment that is derived from a water soluble polymer.Type: GrantFiled: July 8, 2011Date of Patent: June 14, 2016Assignee: INNOCORE TECHNOLOGIES B.V.Inventors: Rob Steendam, Theodorus Adrianus Cornelius Flipsen, Christine Hiemstra, Johan Zuidema
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Publication number: 20150273102Abstract: The invention relates, generally, to porous absorbent materials which are suitable for packing antrums or other cavities of the human or animal body. More particularly, it relates to hydrophilic biodegradable foams, which may be used e.g. in the form of a plug or tampon, for instance for controlling bleeding, wound closure, prevent tissue adhesion and/or support tissue regeneration. The invention provides an absorbent foam, suitable for packing antrums or other cavities of the human or animal body, comprising a biodegradable synthetic polymer, which polymer preferably comprises —C(O)—O— groups in the backbone of the polymer, for instance polyurethane and/or polyester units combined with polyethers.Type: ApplicationFiled: April 24, 2015Publication date: October 1, 2015Applicant: STRYKER EUROPEAN HOLDINGS I, LLCInventors: Catharina Everdina Hissink, Theodorus Adrianus Cornelius Flipsen, Johan Zuidema, Linda Joan Gibcus
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Publication number: 20140199385Abstract: This invention is directed to a biodegradable, semi-crystalline, phase separated thermoplastic multi-block copolymer, a process for preparing said multi-block copolymer, a composition for the delivery of at least one biological active compound, and to a method for delivering a biologically active compound to a subject in need thereof. A multi-block copolymer of the invention is characterised in that: a) it comprises at least one hydrolysable pre-polymer (A) segment and at least one hydrolysable pre-polymer (B) segment, b) said multi-block copolymer having a Tg of 37° C. or less and a Tm of 110-250° C. under physiological conditions; c) the segments are linked by a multifunctional chain-extender; d) the segments are randomly distributed over the polymer chain; e) at least part of the pre-polymer (A) segment is derived from a water-soluble polymer.Type: ApplicationFiled: July 23, 2012Publication date: July 17, 2014Applicant: INNOCORE TECHNOLOGIES B.V.Inventors: Rob Steendam, Theodorus Adrianus Cornelius Flipsen, Christine Hiemstra, Johan Zuidema
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Patent number: 8674033Abstract: The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. According to the invention, a biodegradable, phase separated copolymer is provided, comprising segments of a soft prepolymer (A) having a glass transition temperature, Tg, lower than 37° C.; and segments of a hard prepolymer (B) having a phase transition temperature, Tm, of 40-100° C.Type: GrantFiled: July 16, 2003Date of Patent: March 18, 2014Assignee: Innocore Technologies B.V.Inventors: Catharina Everdina Hissink, Ronald Meyboom, Theodorus Adrianus Cornelius Flipsen
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Patent number: 8674032Abstract: The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.Type: GrantFiled: June 6, 2013Date of Patent: March 18, 2014Assignee: Innocore Technologies B.V.Inventors: Catharina Everdina Hissink, Rob Steendam, Ronald Meyboom, Theodorus Adrianus Cornelius Flipsen
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Publication number: 20130273284Abstract: The invention relates to a biodegradable multi-block copolymer, comprising at least two hydrolysable segments derived from pre-polymers A and B, which segments are linked by a multi-functional chain-extender and are chosen from the pre-polymers A and B, and triblock copolymers ABA and BAB, wherein the multi-block copolymer is amorphous at physiological (body) conditions. The invention further relates to a process for preparing said copolymer and to its use as a medical implant, a coating for a medical device or a drug delivery vehicle.Type: ApplicationFiled: June 6, 2013Publication date: October 17, 2013Applicant: INNOCORE TECHNOLOGIES BVInventors: Catharina Everdina HISSINK, Rob STEENDAM, Ronald MEYBOOM, Theodorus Adrianus Cornelius FLIPSEN