Patents by Inventor Theodorus H. A. Peters

Theodorus H. A. Peters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amlodipine free base
    Patent number: 7335380
    Abstract: Amlodipine free base can be formulated into a convenient oral dosage form, especially a tablet, without excessive stickiness or tablet punch residue. The amlodipine free base can be crystalline Form I or a novel Form II. Methods of making and using the amlodipine free base are set forth.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: February 26, 2008
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker, Rolf Keltjens
  • Synthesis of olanzapine and intermediates thereof
    Patent number: 7329747
    Abstract: Olanzapine and salts thereof are made by a process that utilizes an N-formyl olanzapine intermediate of formula (4) or a salt thereof
    Type: Grant
    Filed: January 27, 2005
    Date of Patent: February 12, 2008
    Assignee: Synthon IP Inc.
    Inventors: Rolf Keltjens, Theodorus H. A. Peters
  • Amide derivative of amlodipine
    Patent number: 7199247
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: April 3, 2007
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Amide derivative of amlodipine
    Patent number: 7115638
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension
    Type: Grant
    Filed: May 12, 2003
    Date of Patent: October 3, 2006
    Assignee: Synthon IP Inc.
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
    Patent number: 6965051
    Abstract: Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: November 15, 2005
    Assignee: Synthon IP Inc.
    Inventors: Hans J. Hoorn, Theodorus H. A. Peters, Jaroslav Pis, Radim Scigel
  • Process for making amlodipine, derivatives thereof, and precursors therefor
    Patent number: 6858738
    Abstract: Amlodipine and related analogues thereof are prepared by the following general reaction scheme: R1 and R2 each independently represent a C1-C4 alkyl group. The process provides for the formation of compounds of formula (1) in good yield and purity. Further, the compounds of formula (1) can be used as calcium channel blockers or as reference standards or reference markers for checking the purity of amlodipine.
    Type: Grant
    Filed: May 8, 2003
    Date of Patent: February 22, 2005
    Assignee: Synthon BV
    Inventors: Theodorus H. A. Peters, Franciscus B. G. Benneker, Pavel Slanina, Jiri Bartl
  • N-formyl derivatives of paroxetine
    Publication number: 20040266825
    Abstract: A compound or composition comprising N-formyl paroxetine of formula (1) is useful as a pharmaceutical and as a synthetic intermediate. The N-formyl paroxetine can be an impurity in paroxetine substances and methods of assaying for such an impurity are also useful.
    Type: Application
    Filed: January 20, 2004
    Publication date: December 30, 2004
    Inventors: Hans J. Hoorn, Theodorus H.A. Peters, Frantisek Picha
  • Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith
    Patent number: 6835853
    Abstract: Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: December 28, 2004
    Assignee: Synthon BV
    Inventors: Hans J Hoorn, Theodorus H. A. Peters, Jaroslav Pis, Radim Scigel
  • Reference standards for determining the purity or stability of amlodipine maleate and processes therefor
    Patent number: 6830933
    Abstract: Amlodipine aspartate and amlodipine maleamide are used as reference standards or markers in determining the purity of amlodipine maleate substances and products.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: December 14, 2004
    Assignee: Synthon BV
    Inventors: Jacobus M Lemmens, Theodorus H. A. Peters, Peter F. A. Bakker, Frantisek Picha
  • N-formyl derivatives of paroxetine
    Publication number: 20040147497
    Abstract: A compound or composition comprising N-formyl paroxetine of formula (1) is useful as a pharmaceutical and as a synthetic intermediate. The N-formyl paroxetine can be an impurity in paroxetine substances and methods of assaying for such an impurity are also useful.
    Type: Application
    Filed: January 20, 2004
    Publication date: July 29, 2004
    Inventors: Hans J. Hoorn, Theodorus H.A. Peters, Frantisek Picha
  • Process for the production of paroxetine
    Publication number: 20040138460
    Abstract: The synthesis of paroxetine can be made more convenient by using a solvent system comprising an aliphatic alcohol and a hydrocarbon co-solvent. The solvent system is used particularly in the hydrolysis of paroxetine phenylcarbamate and preferably uses butanol and toluene as the system.
    Type: Application
    Filed: December 23, 2003
    Publication date: July 15, 2004
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Frantisek Picha
  • Paroxetine compositions and processes for making the same
    Publication number: 20040067254
    Abstract: Paroxetine salt compositions having improved stability are formed by controlling the pH to 6.5 or less. The compositions can be made with the aide of water without significant coloration problems. The paroxetine salts include paroxetine hydrochloride salts but preferably use paroxetine sulfonate salts such as paroxetine methane sulfonate.
    Type: Application
    Filed: October 6, 2003
    Publication date: April 8, 2004
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Frantisek Picha, Johannes J. Platteeuw, Frans van Dalen
  • N-formyl derivatives of paroxetine
    Patent number: 6703408
    Abstract: A compound or composition comprising N-formyl paroxetine of formula (1) is useful as a pharmaceutical and as a synthetic intermediate. The N-formyl paroxetine can be an impurity in paroxetine substances and methods of assaying for such an impurity are also useful.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: March 9, 2004
    Assignee: Synthon BCT Technologies, LLC
    Inventors: Hans J. Hoorn, Theodorus H. A. Peters, Frantisek Picha
  • Process for the production of paroxetine
    Patent number: 6686473
    Abstract: The synthesis of paroxetine can be made more convenient by using a solvent system comprising an aliphatic alcohol and a hydrocarbon co-solvent. The solvent system is used particularly in the hydrolysis of paroxetine phenylcarbamate and preferably uses butanol and toluene as the system.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: February 3, 2004
    Assignee: Synthon BCT Technologies, LLC
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Frantisek Picha
  • Process for making amlodipine, derivatives thereof, and precursors therefor
    Publication number: 20030220501
    Abstract: Amlodipine and related analogues thereof are prepared by the following general reaction scheme: 1
    Type: Application
    Filed: May 8, 2003
    Publication date: November 27, 2003
    Inventors: Theodorus H. A. Peters, Franciscus B. G. Benneker, Pavel Slanina, Jiri Bartl
  • Process for making amlodipine
    Patent number: 6653481
    Abstract: Amlodipine and related analogues thereof are prepared by the following general reaction scheme: R1 and R2 each independently represent a C1-C4 alkyl group. The process provides for the formation of compounds of formula (1) in good yield and purity. Further, the compounds of formula (1) can be used as calcium channel blockers or as reference standards or reference markers for checking the purity of amlodipine.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: November 25, 2003
    Assignee: Synthon BV
    Inventors: Theodorus H. A. Peters, Franciscus B. G. Benneker, Pavel Slanina, Jiri Bartl
  • Paroxetine compositions and processes for making the same
    Patent number: 6645523
    Abstract: Paroxetine salt compositions having improved stability are formed by controlling the pH to 6.5 or less. The compositions can be made with the aide of water without significant coloration problems. The paroxetine salts include paroxetine hydrochloride salts but preferably use paroxetine sulfonate salts such as paroxetine methane sulfonate.
    Type: Grant
    Filed: August 28, 2001
    Date of Patent: November 11, 2003
    Assignee: Synthon BCT Technologies, LLC
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Frantisek Picha, Johannes J. Platteeuw, Frans van Dalen
  • Amide derivative of amlodipine
    Publication number: 20030204093
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension.
    Type: Application
    Filed: May 12, 2003
    Publication date: October 30, 2003
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • Amide derivative of amlodipine
    Patent number: 6602893
    Abstract: A derivative of amlodipine having the following formula is useful as a pharmaceutical, either alone or in combination with amlodipine, in treating angina and hypertension.
    Type: Grant
    Filed: August 27, 2001
    Date of Patent: August 5, 2003
    Assignee: Synthon BV
    Inventors: Jacobus M. Lemmens, Theodorus H. A. Peters, Franciscus B. G. Benneker
  • N-formyl derivatives of paroxetine
    Publication number: 20030125560
    Abstract: A compound or composition comprising N-formyl paroxetine of formula (1) is useful as a pharmaceutical and as a synthetic intermediate. The N-formyl paroxetine can be an impurity in paroxetine substances and methods of assaying for such an impurity are also useful.
    Type: Application
    Filed: October 21, 2002
    Publication date: July 3, 2003
    Inventors: Hans J. Hoorn, Theodorus H.A. Peters, Frantisek Picha