Patents by Inventor Theodorus Hendricus Antonius Peters

Theodorus Hendricus Antonius Peters has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles
    Patent number: 6770761
    Abstract: A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R3 and R4 are either the same and each of them represents an alkoxy group of 1-4 carbons or they together form a C2-C5 alkylenedioxy group or an oxo-group, with an alkylamine in the presence of a reducing agent or a hydrogen gas with hydrogenation catalyst. A process to obtain new compounds of formula (6) is also described.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: August 3, 2004
    Assignee: Synthon BV
    Inventors: Karel Pospisilik, Hans Jan Hoorn, Theodorus Hendricus Antonius Peters, Jacobus Maria Lemmens
  • Pharmaceutical tablet comprising paroextine mesylate
    Publication number: 20040086559
    Abstract: The invention is directed to novel and advantageous pharmaceutical compositions for oral administration of the antidepressant compound paroxetine. The composition is in the form of a tablet having a dissolution rate of at least 90% in 30 minutes measured with a paddle apparatus according to US Pharmacopoeia.
    Type: Application
    Filed: December 23, 2003
    Publication date: May 6, 2004
    Inventors: Theodorus Hendricus Antonius Peters, Frans van Dalen, Jacobus Maria Lemmens, Frantisek Picha
  • Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles
    Publication number: 20040029936
    Abstract: A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R3 and R4 are either the same and each of them represents an alkoxy group of 1-4 carbons or they together form a C2-C5 alkylenedioxy group or an oxo-group, with an alkylamine in the presence of a reducing agent or a hydrogen gas with hydrogenation catalyst. A process to obtain new compounds of formula (6) is also described.
    Type: Application
    Filed: August 7, 2003
    Publication date: February 12, 2004
    Inventors: Karel Pospisilik, Hans Jan Hoorn, Theodorus Hendricus Antonius Peters, Jacobus Maria Lemmens
  • Imidazopyridine derivatives and process for making them
    Patent number: 6281360
    Abstract: Imidazopyridine compounds of the formula 1 are can be made in high purity, e.g. greater than 95% pure, by a process that use a novel intermediate of formula 5: wherein R1 and R2 each independently represent hydrogen or a lower alkyl group and Y and Z each independently represent a lower alkyl group. By this process, zolpidem, a commercial pharmaceutical of the formula 1 can be effectively made.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: August 28, 2001
    Assignee: Synthon BV
    Inventors: Gerrit Jan Bouke Ettema, Jacobus Maria Lemmens, Theodorus Hendricus Antonius Peters, Frantisek Picha
  • Zolpidem salt forms
    Patent number: 6242460
    Abstract: Zolpidem salts having improved physical stability do not exhibit a melting endotherm corresponding to zolpidem free base when heated at 5° C./minute from about 25° C. to 250° C. The salts are generally easy to reproduce, even on an industrial scale and are easier to handle due to the increased stability than the known zolpidem tartrate. The zolpidem salts are typically pharmaceutically acceptable salts and can be used in formulating pharmaceutical compositions and in pharmaceutical uses; e.g. as a hypnotic.
    Type: Grant
    Filed: November 26, 1999
    Date of Patent: June 5, 2001
    Assignee: Synthon BV
    Inventors: Gerrit Jan Bouke Ettema, Jacobus Maria Lemmens, Theodorus Hendricus Antonius Peters, Frantisek Picha