Patents by Inventor THEOFANIS MANTOURLIAS

THEOFANIS MANTOURLIAS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AQUEOUS, ROOM-TEMPERATURE STABLE ROCURONIUM COMPOSITION
    Publication number: 20230014293
    Abstract: The invention relates to a rocuronium composition providing no or less vascular pain to patients upon injection. The rocuronium composition has a pH of 2.5 to 3.5 and a titratable acidity of not more than 35 mEq. The rocuronium composition is stable upon thermal sterilization. Further, the rocuronium composition is stable upon storage at room-temperature.
    Type: Application
    Filed: August 19, 2021
    Publication date: January 19, 2023
    Applicant: FRESENIUS KABI AUSTRIA GMBH
    Inventors: Christian MASSER, Birgit STEINER-ZITZENBACHER, Theofanis MANTOURLIAS
  • Preparation of polylactide-polyglycolide microparticles having a sigmoidal release profile
    Patent number: 9943484
    Abstract: The present invention relates to preparation of biodegradable microparticles formed from polylactide-polyglycolide copolymers (PLGA) polymer and how to achieve sigmoidal release of active pharmaceutical compound from the microparticles. In particular, the present invention relates to emulsification of an inner/oil phase to an outer/water phase followed by quenching and a single drying step for the preparation of microparticles having a preferred release profile of preferably basic/nucleophilic compounds such as risperidone. Alternatively the present invention is also suitable for hydrophobic compounds that have poor water-solubility and a high drug loading of >20% w/w is required. The release profile can be controlled by adjusting the degree of saturation of the outer/water phase with the organic solvent used in the inner/oil phase, the polymer concentration of the inner/oil phase and the temperature at the quenching step.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: April 17, 2018
    Assignee: PHARMATHEN S.A.
    Inventors: Evangelos Karavas, Efthymios Koutris, Sotiria Haitidou, Theofanis Mantourlias, Georgia Papanikolaou
  • Preparation of peptide loaded PLGA microspheres with controlled release characteristics
    Patent number: 9943483
    Abstract: A novel process for the preparation of a long acting injectable composition based on biodegradable poly(D,L-lactide-co-glycolide) microspheres comprising peptide active pharmaceutical ingredients.
    Type: Grant
    Filed: March 31, 2014
    Date of Patent: April 17, 2018
    Assignee: PHARMATHEN S.A.
    Inventors: Evangelos Karavas, Efthymios Koutris, Katerina Minioti, Sotiria Chaitidou, Georgia Papanikolaou, Theofanis Mantourlias
  • PREPARATION OF PEPTIDE LOADED PLGA MICROSPHERES WITH CONTROLLED RELEASE CHARACTERISTICS
    Publication number: 20170281547
    Abstract: A novel process for the preparation of a long acting injectable composition based on biodegradable poly(D,L-lactide-co-glycolide) microspheres comprising peptide active pharmaceutical ingredients.
    Type: Application
    Filed: March 31, 2016
    Publication date: October 5, 2017
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, KATERINA MINIOTI, SOTIRIA CHAITIDOU, GEORGIA PAPANIKOLAOU, THEOFANIS MANTOURLIAS
  • PREPARATION OF POLYLACTIDE-POLYGLYCOLIDE MICROPARTICLES HAVING A SIGMOIDAL RELEASE PROFILE
    Publication number: 20160143851
    Abstract: The present invention relates to preparation of biodegradable microparticles formed from polylactide-polyglycolide copolymers (PLGA) polymer and how to achieve sigmoidal release of active pharmaceutical compound from the microparticles. In particular, the present invention relates to emulsification of an inner/oil phase to an outer/water phase followed by quenching and a single drying step for the preparation of microparticles having a preferred release profile of preferably basic/nucleophilic compounds such as risperidone. Alternatively the present invention is also suitable for hydrophobic compounds that have poor water-solubility and a high drug loading of >20% w/w is required. The release profile can be controlled by adjusting the degree of saturation of the outer/water phase with the organic solvent used in the inner/oil phase, the polymer concentration of the inner/oil phase and the temperature at the quenching step.
    Type: Application
    Filed: June 18, 2014
    Publication date: May 26, 2016
    Applicant: PHARMATHEN S.A.
    Inventors: EVANGELOS KARAVAS, EFTHYMIOS KOUTRIS, SOTIRIA HAITIDOU, THEOFANIS MANTOURLIAS, GEORGIA PAPANIKOLAOU