Patents by Inventor Theresa Devlin

Theresa Devlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Base protecting groups and synthons for oligonucleotide synthesis
    Patent number: 6531589
    Abstract: The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotides under more mild conditions than existing methods. The invention further provides a nucleoside base protecting group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protecting groups, as well as nucleoside synthons having such base protecting groups.
    Type: Grant
    Filed: February 8, 1996
    Date of Patent: March 11, 2003
    Assignee: Hybridon, Inc.
    Inventors: Radhakrishnan P. Iyer, Theresa Devlin, Ivan Habus, Dong Yu, Sudhir Agrawal, Nan-Hui Ho
  • Primary phosphoramidate internucleoside linkages and oligonucleotides containing the same
    Patent number: 6140482
    Abstract: The invention provides new primary phosphoramidate internucleoside linkages that are less sterically constrained than existing phosphoramidate linkages, as well as oligonucleotides containing such linkages and processes for making and methods for using such oligonucleotides.
    Type: Grant
    Filed: August 25, 1995
    Date of Patent: October 31, 2000
    Assignee: Hybridon, Inc.
    Inventors: Radhakrishnan P. Iyer, Theresa Devlin, Ivan Habus, Dong Yu, Sudhir Agrawal
  • Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages
    Patent number: 5962674
    Abstract: The invention provides new reagents and an improved process for synthesizing oligonucleotides that contain methylphosphonate internucleoside linkages. The reagents and process utilize a nucleoside base protecting group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protecting groups.
    Type: Grant
    Filed: February 26, 1996
    Date of Patent: October 5, 1999
    Assignee: Hybridon, Inc.
    Inventors: Radhakrishnan P. Iyer, Theresa Devlin, Ivan Habus, Dong Yu, Sudhir Agrawal
  • Process for making oligonucleotides containing o- and s- methylphosphotriester internucleoside linkages
    Patent number: 5955599
    Abstract: The invention provides oligonucleotides containing methyl phosphotriester linkages and processes for making and methods for using such oligonucleotides.
    Type: Grant
    Filed: December 11, 1995
    Date of Patent: September 21, 1999
    Assignee: Hybridon, Inc.
    Inventors: Radhakrishnan P. Iyer, Theresa Devlin, Ivan Habus, Dong Yu, Sudhir Agrawal
  • 5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses
    Patent number: 5614622
    Abstract: The invention provides new methods for synthesizing oligonucleotides that allow for deprotection of the oligonucleotide under more mild conditions than existing methods. The invention further provides a nucleoside base protective group that is stable under oligonucleotide synthesis conditions, but which can be removed under more mild conditions than existing protective groups, as well as nucleoside synthons having such base protective groups.
    Type: Grant
    Filed: August 24, 1995
    Date of Patent: March 25, 1997
    Assignee: Hybridon, Inc.
    Inventors: Radhakrishnan P. Iyer, Theresa Devlin, Ivan Habus, Dong Yu, Sudhir Agrawal
  • Solutions of pentamidine
    Patent number: 4853416
    Abstract: A pharmaceutical composition comprising an aqueous solution of pentamidine or a pharmaceutically acceptable salt thereof, the solution having a pH of less than 4.5. The pH of the solution is preferably less than 4.0, more preferably less than 3.5, and especially less than 3.0.Also disclosed is a method for the prophylactic or remedial treatment of pneumo-cystis carinii pneumonia, which method comprises administration by inhalation to a patient having or being susceptible to that condition of a therapeutically effective quantity of an aqueous solution of pentamidine, or a pharmaceutically acceptable salt thereof, the solution having a pH of less than 4.5.
    Type: Grant
    Filed: April 25, 1988
    Date of Patent: August 1, 1989
    Assignee: Fisons Corporation
    Inventors: Aloysius Anaebonam, Emmett Clemente, Theresa Devlin, Diane Ringden