Patents by Inventor Theresa M. Reineke
Theresa M. Reineke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230322834Abstract: Provided herein are polymers derived from levoglucosan, methods of preparing said polymers, and methods of modifying said polymers.Type: ApplicationFiled: April 6, 2023Publication date: October 12, 2023Inventors: Theresa M. Reineke, Christopher J. Ellison, Mayuri Kiran Porwal, Derek J. Saxon
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Patent number: 11396571Abstract: Block copolymers that include one or more galactose based blocks and one or more cationic blocks; polyplexes including disclosed block copolymers and one or more nucleic acids; and methods of delivering a nucleic acid to a cell which can include delivering a polyplex to the cell.Type: GrantFiled: May 27, 2016Date of Patent: July 26, 2022Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Theresa M. Reineke, Yogesh Khemchandra Dhande, Bharat Sanjay Wagh
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Publication number: 20220136973Abstract: Methods and systems related to a linear polymer affinity agent sensor for SERS are disclosed. Use of the sensor may include mixing a linear polymer affinity agent in a sample solution, subjecting a metal substrate to the sample solution to attach the linear polymer affinity agent to the metal substrate, generating, via Raman Spectroscopy, spectral data representing the at least one linear polymer affinity agent attached to the metal substrate, and determining whether two or more analytes are present in the solution at respective minimum threshold concentrations based on the spectral data.Type: ApplicationFiled: October 29, 2021Publication date: May 5, 2022Inventors: Rebeca S. Rodriguez, Victoria M. Szlag, Theresa M. Reineke, Christy L. Haynes
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Patent number: 10717799Abstract: The present invention relates to the use of uncrosslinked copolymers having a backbone comprising i) a plurality of thermo-responsive structural units derived from one or more than one N-alkyl or N,N-dialkyl substituted (alkyl)acrylamide monomer and ii) a plurality of hydrophilic structural units derived from one or more than one second ethylenically unsaturated monomer as excipients in solid mixtures with poorly water-soluble substances for effective solubilization of the latter in aqueous media. Solid dosage forms comprising a solid mixture of such copolymer(s) and poorly water-soluble substance(s) are also within the scope of the invention.Type: GrantFiled: February 24, 2016Date of Patent: July 21, 2020Assignees: Dow Global Technologies LLC, Rohm and Haas Company, Regents of the University of MinnesotaInventors: Swapnil Tale, Theresa M. Reineke, Frank S. Bates, Jeffrey M. Ting, Lakmini Widanapathirana, Steven J. Guillaudeu, Li Guo
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Patent number: 10030089Abstract: Disclosed herein are polymers made from at least three monomers of formulae (I), (II), (III), and (IV) that may be used in pharmaceutical formulations. These polymers comprise a hydrocarbon backbone and are made from monomers that contain at least one carbon-carbon double bond. Methods of making the polymers are also disclosed.Type: GrantFiled: May 6, 2014Date of Patent: July 24, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF MINNESOTAInventors: Tushar S. Navale, Jeffrey M. Ting, Frank S. Bates, Theresa M. Reineke
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Patent number: 9944740Abstract: Disclosed herein are polymers made from at least one monomer of formulae (I), (II), (III), and (IV), in combination with a monomer of formula (V) that may be used in pharmaceutical formulations. These polymers comprise a hydrocarbon backbone and are made from monomers that contain at least one carbon-carbon double bond. Methods of making these polymers are also disclosed.Type: GrantFiled: May 6, 2014Date of Patent: April 17, 2018Assignee: Regents of the University of MinnesotaInventors: Tushar S. Navale, Jeffrey M. Ting, Frank S. Bates, Theresa M. Reineke
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Publication number: 20180066091Abstract: The present invention relates to the use of uncrosslinked copolymers having a backbone comprising i) a plurality of thermo-responsive structural units derived from one or more than one N-alkyl or N,N-dialkyl substituted (alkyl)acrylamide monomer and ii) a plurality of hydrophilic structural units derived from one or more than one second ethylenically unsaturated monomer as excipients in solid mixtures with poorly water-soluble substances for effective solubilization of the latter in aqueous media. Solid dosage forms comprising a solid mixture of such copolymer(s) and poorly water-soluble substance(s) are also within the scope of the invention.Type: ApplicationFiled: February 24, 2016Publication date: March 8, 2018Inventors: Swapnil Tale, Theresa M. Reineke, Frank S. Bates, Jeffrey M. Ting, Lakmini Widanapathirana, Steven J. Guillaudeu, Li Guo
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Publication number: 20160346395Abstract: Block copolymers that include one or more galactose based blocks and one or more cationic blocks; polyplexes including disclosed block copolymers and one or more nucleic acids; and methods of delivering a nucleic acid to a cell which can include delivering a polyplex to the cell.Type: ApplicationFiled: May 27, 2016Publication date: December 1, 2016Inventors: Theresa M. Reineke, Yogesh Khemchandra Dhande, Bharat Sanjay Wagh
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Publication number: 20160120984Abstract: Disclosed herein are polymers made from at least one monomer of formulae (I), (II), (III), and (IV), in combination with a monomer of formula (V) that may be used in pharmaceutical formulations. These polymers comprise a hydrocarbon backbone and are made from monomers that contain at least one carbon-carbon double bond. Methods of making these polymers are also disclosed.Type: ApplicationFiled: May 6, 2014Publication date: May 5, 2016Applicant: Regents of the University of MinnesotaInventors: Tushar S. NAVALE, Jeffrey M. TING, Frank S. BATES, Theresa M. REINEKE
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Publication number: 20160083492Abstract: Disclosed herein are polymers made from at least three monomers of formulae (I), (II), (III), and (IV) that may be used in pharmaceutical formulations. These polymers comprise a hydrocarbon backbone and are made from monomers that contain at least one carbon-carbon double bond. Methods of making the polymers are also disclosed.Type: ApplicationFiled: May 6, 2014Publication date: March 24, 2016Inventors: Tushar S. NAVALE, Jeffrey M. TING, Frank S. BATES, Theresa M. REINEKE
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Patent number: 8685368Abstract: A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including, a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response is provided. Complexes including a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells is also provided. The cellular delivery molecules may include one or more polymers, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.Type: GrantFiled: July 3, 2012Date of Patent: April 1, 2014Inventor: Theresa M. Reineke
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Patent number: 8501478Abstract: Novel trehalose click polymers have in vitro and in vivo application in the cellular delivery of biologically active molecules, including nucleic acids and polypeptides. The trehalose click polymers of the present invention provide increased stability in serum as compared with other non-viral vectors, and are particularly useful in protecting nucleic acids against degradation.Type: GrantFiled: June 6, 2008Date of Patent: August 6, 2013Assignee: University of CincinnatiInventors: Theresa M. Reineke, Sathya Srinivasachari
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Publication number: 20120270927Abstract: A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including, a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response is provided. Complexes including a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells is also provided. The cellular delivery molecules may include one or more polymers, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.Type: ApplicationFiled: July 3, 2012Publication date: October 25, 2012Inventor: Theresa M. Reineke
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Patent number: 8236280Abstract: A new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications, including a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response is provided. Complexes including a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells are also provided. The cellular delivery molecules may include one or more polymers, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.Type: GrantFiled: March 10, 2011Date of Patent: August 7, 2012Assignee: University of CincinnatiInventor: Theresa M. Reineke
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Patent number: 8034619Abstract: The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA containing a sequence or sequences that act as transcription factor decoys.Type: GrantFiled: December 20, 2004Date of Patent: October 11, 2011Assignee: University of CincinnatiInventors: Theresa M. Reineke, Walter Keith Jones
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Publication number: 20110183417Abstract: The present invention provides a new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications. In particular, these vectors can be used for gene transfer applications. These new gene transduction vectors can achieve transfer efficiencies far greater to commercially available polymeric and liposomal gene transfer vectors while maintaining little or no toxicity in vitro. Their low in vitro toxicity makes them ideal candidates for in vivo use. The present invention also provides a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response. Furthermore, the unique polycationic structure of these polymers associates with many suitable biologically active molecule, including oligonucleotides and polypeptides and other compounds that poses multiple cationic sites.Type: ApplicationFiled: March 10, 2011Publication date: July 28, 2011Inventor: Theresa M. Reineke
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Patent number: 7927873Abstract: The present invention provides a new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications. The present invention also provides a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response. Complexes according to the invention or portions thereof, can comprise a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells. In some embodiments, cellular delivery molecules for use in the present invention may comprise one or more polymers of the present invention, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.Type: GrantFiled: December 20, 2004Date of Patent: April 19, 2011Assignee: University of CincinnatiInventor: Theresa M. Reineke
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THERANOSTIC POLYCATION BEACONS COMPRISING OLIGOETHYLENEAMINE REPEATING UNITS AND LANTHANIDE CHELATES
Publication number: 20110009478Abstract: The present invention relates to vehicles for delivering macromolecules into cells. More particularly, embodiments of the invention relate to compounds and methods for binding and compacting nucleic acids into nanoparticles for transferring the polynucleotides into cells and which can be configured to provide a mechanism for visualization of the delivery vehicles on the nm/?m scale by microscopy and on the sub-mm scale by magnetic resonance imaging. Polycations according to embodiments of the invention have been designed to contain repeated oligoethyleneamines, for binding and compacting nucleic acids into nanoparticles, and lanthanide (Ln) chelates (for example, using luminescent europium Eu3+ and paramagnetic gadolinium Gd3+).Type: ApplicationFiled: July 8, 2010Publication date: January 13, 2011Inventors: Theresa M. REINEKE, Joshua M. Bryson -
Publication number: 20090203131Abstract: The present invention describes reagents and methods for using concatermized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end copies of a short dsDNA containing a sequence or sequences that act as transcription factor decoys.Type: ApplicationFiled: December 20, 2004Publication date: August 13, 2009Applicant: UNIVERSITY OF CINCINNATIInventors: Theresa M. Reineke, Walter Keith Jones
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Publication number: 20090105115Abstract: The present invention provides a new class of non-viral transduction vectors that can be used for both in vivo and in vitro applications. The present invention also provides a gene transfer vector that has comparable efficiency to a viral vector without the potential for a life-threatening immune response. Complexes according to the invention or portions thereof, can comprise a cellular delivery molecule or agent that can facilitate the translocation of the complex or portion thereof into cells. In some embodiments, cellular delivery molecules for use in the present invention may comprise one or more polymers of the present invention, e.g., polyamides, dendritic macromolecules and carbohydrate-containing degradable polyesters.Type: ApplicationFiled: December 20, 2004Publication date: April 23, 2009Inventor: Theresa M. Reineke