Patents by Inventor Therese Cotton

Therese Cotton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Surface-enhanced raman spectroscopy immunoassay method, composition and kit
    Patent number: 5567628
    Abstract: A method, composition, device, apparatus, and kit for the determination of the presence or amount of an analyte by monitoring an analyte-mediated ligand binding event in a test mixture which contains the analyte to be assayed, a specific binding member, a Raman-active label, and a particulate having a surface capable of inducing a surface-enhanced Raman light scattering. The test mixture is illuminated with a radiation sufficient to cause the Raman-active label in the test mixture to emit a detectable Raman spectrum. The differences in the detected surface-enhanced Raman scattering spectra are dependent upon the amount of the analyte present in the test mixture. Thus, by monitoring these differences, the presence or amount of the analyte are determined.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: October 22, 1996
    Assignee: Abbott Laboratories
    Inventors: Peter J. Tarcha, Thomas E. Rohr, James J. Markese, Therese Cotton, Bernard N. Rospendowski
  • Raman label and its conjugate in a ligand-binding assay for a test sample analyte
    Patent number: 5445972
    Abstract: A Raman label which, upon radiation, produces a detectable Raman scattering signal in a ligand-binding assay for an analyte in a test sample. A conjugate containing a Raman label attached to a specific binding member.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: August 29, 1995
    Assignee: Abbott Laboratories
    Inventors: Peter J. Tarcha, Thomas E. Rohr, Therese Cotton, Gary E. Winter
  • Surface-enhanced Raman spectroscopy immunoassay
    Patent number: 5376556
    Abstract: A method, composition, device, apparatus, and kit for the determination of the presence or amount of an analyte by monitoring an analyte-mediated ligand binding event in a test mixture which contains the analyte to be assayed, a specific binding member, a Raman-active label, and a particulate having a surface capable of inducing a surface-enhanced Raman light scattering. The test mixture is illuminated with a radiation sufficient to cause the Raman-active label in the test mixture to emit a detectable Raman spectrum. The differences in the detected surface-enhanced Raman scattering spectra are dependent upon the amount of the analyte present in the test mixture. Thus, by monitoring these differences, the presence or amount of the analyte are determined.
    Type: Grant
    Filed: September 11, 1992
    Date of Patent: December 27, 1994
    Assignee: Abbott Laboratories
    Inventors: Peter J. Tarcha, Thomas E. Rohr, James J. Markese, Therese Cotton, Bernard N. Rospendowski
  • Ligand binding assay for an analyte using surface-enhanced scattering (SERS) signal
    Patent number: 5266498
    Abstract: An assay for an analyte in a test sample that uses a ligand binding reaction between the analyte and a specific binding member or a binding member pair that includes one binding member having a Raman active reporter. The analyte can be assayed by measurement of the Raman scattering signal of the Raman-active reporter. The Raman scattering signal can be either a noon-enhanced Raman scattering signal or a Raman scattering signal that is enhanced by a surface capable of enhancing that Raman scattering signal.
    Type: Grant
    Filed: November 7, 1991
    Date of Patent: November 30, 1993
    Assignee: Abbott Laboratories
    Inventors: Peter J. Tarcha, Thomas E. Rohr, Therese Cotton