Patents by Inventor Therese Ternynck

Therese Ternynck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei
    Patent number: 8003595
    Abstract: The invention concerns an amino acid sequence capable of facilitating penetration of a substance of interest into cells and/or cell nuclei, characterized in that it is capable of reacting in vivo with aminoglycans. Optionally the sequence is derived from a protein of human origin.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: August 23, 2011
    Assignee: Cellectis
    Inventors: Eustrate Avrameas, Therese Ternynck
  • IMMUNOVECTORS WHICH CAN BE USED FOR THE INTRACELLULAR AND INTRANUCLEAR TRANSPORT
    Publication number: 20110020928
    Abstract: A method of transferring a biologically active principle of interest into a cell by coupling an antibody or a fragment of an antibody, which recognizes an epitope contained in a nucleic acid, with the biologically active principle, to form a coupled biologically active principle; and incubating the coupled biologically active principle, which is transferred through the cell membrane and into the cell, with the cell.
    Type: Application
    Filed: October 6, 2010
    Publication date: January 27, 2011
    Applicants: INSTITUT PASTEUR, Universite Pierre et Marie Curie
    Inventors: Stratis AVRAMEAS, Gerard Buttin, Therese Ternynck, Faridabano Nato, Alexandre Avrameas
  • Vectors derived from antibodies for transferring substances into cells
    Patent number: 7628987
    Abstract: The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: December 8, 2009
    Assignees: Institut Pasteur, Universite Pierre et Marie Curie
    Inventors: Therese Ternynck, Alexandre Avrameas, Gerard Buttin, Stratis Avrameas, Marie-Francoise Saron, Bruno Blondel, Therese Couderc, Susan Michelson, Donato Zipeto
  • Vectors derived from antibodies for transferring substances into cells
    Publication number: 20070098741
    Abstract: The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.
    Type: Application
    Filed: July 10, 2006
    Publication date: May 3, 2007
    Applicants: INSTITUT PASTEUR, Universite Pierre et Marie Curie
    Inventors: Therese Ternynck, Alexandre Avrameas, Gerard Buttin, Stratis Avrameas, Marie-Francoise Saron, Bruno Blondel, Therese Couderc, Susan Michelson, Donato Zipeto
  • Immunovectors which can be used for the intracellular and intranuclear transport
    Publication number: 20040259822
    Abstract: A product for coupling a biologically active principle with an immunovector, characterized in that the immunovector is capable of enabling the biologically active principle to be internalized into eukaryotic cells, and in that said immunovector has an affinity for the cell DNA to such an extent that it can transfer the biologically active principle into or to the immediate vicinity of the cell nuclei.
    Type: Application
    Filed: June 20, 2003
    Publication date: December 23, 2004
    Applicants: INSTITUT PASTEUR, Universite Pierre et Marie Curie
    Inventors: Stratis Avrameas, Gerard Buttin, Therese Ternynck, Faridabano Nato, Alexandre Avrameas
  • Vectors derived from antibodies for transferring substances into cells
    Publication number: 20030206900
    Abstract: The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.
    Type: Application
    Filed: June 13, 2003
    Publication date: November 6, 2003
    Applicants: INSTITUT PASTEUR, Universite Pierre et Marie Curie
    Inventors: Therese Ternynck, Alexandre Avrameas, Gerard Buttin, Stratis Avrameas, Marie-Francoise Saron, Bruno Blondel, Therese Couderc, Susan Michelson, Donato Zipeto
  • Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei
    Publication number: 20030199677
    Abstract: The invention concerns an amino acid sequence capable of facilitating penetration of a substance of interest into cells and/or cell nuclei, characterized in that it is capable of reacting in vivo with aminoglycans. Optionally the sequence is derived from a protein of human origin.
    Type: Application
    Filed: August 29, 2002
    Publication date: October 23, 2003
    Inventors: Eustrate Avrameas, Therese Ternynck
  • Single-chain antibody fragments for transferring substances into cells
    Patent number: 6635248
    Abstract: The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: October 21, 2003
    Assignees: Institut Pasteur, Universite Pierre et Marie Curie
    Inventors: Therese Ternynck, Alexandre Avrameas, Gerard Buttin, Stratis Avrameas, Marie-Francoise Saron, Bruno Blondel, Therese Couderc, Susan Michelson, Donato Zipeto
  • Immunovectors for the intracellular and intranuclear transport
    Patent number: 6608034
    Abstract: A product for coupling a biologically active principle with an immunovector, characterized in that the immunovector is capable of enabling the biologically active principle to be internalized into eukaryotic cells, and in that said immunovector has an affinity for the cell DNA to such an extent that it can transfer the biologically active principle into or to the immediate vicinity of the cell nuclei.
    Type: Grant
    Filed: April 28, 1998
    Date of Patent: August 19, 2003
    Assignees: Institut Pasteur, Universite Pierre et Marie Curie (Paris VI)
    Inventors: Stratis Avrameas, Gerard Buttin, Therese Ternynck, Faridabano Nato, Alexandre Avrameas
  • Non-radioactive labelled single-stranded probe, method for manufacturing it and method for detecting a specified nucleotide sequence using this probe
    Patent number: 4978749
    Abstract: The invention relates to a new probe for detecting a specified nucleic acid sequence. It consists of a recombinant DNA containing an insert complementary to the nucleic acid sequence to be detected and nuclecic acid sequences derived from the DNA (+) of phage M13, the bases which participate in the composition of this recombinant DNA, in particular the thymine groups, being replaced by 5-bromouracil groups. The invention also relates to a method for manufacturing this probe, this method comprising the culturing of cell hosts, more especially E. coli, which are auxotrophic for thymine in a medium containing a limiting concentration of thymine and containing 5-bromouracil. After the requisite incubation time, the supernatant is removed and the probe is recovered from the bacterial cells.
    Type: Grant
    Filed: July 11, 1989
    Date of Patent: December 18, 1990
    Assignees: Institute Pasteur, Centre National de la Recherche Scientifique
    Inventors: Avrameas Stratis, Hiroshi Sakamoto, Francois Traincard, Tuyen Vo Quang, Jean-Luc Guesdon, Therese Ternynck