Abstract: A method of whole-brain EEG neurofeedback training of a trainee using live Z-scores from 4 channels of EEG signals to acquire 248 Z-scores from 6 simultaneous interconnectivity paths. The feedback system is endowed with the ability to establish training targets and to use derived metrics to produce feedback of an auditory, visual, vibrotactile, or other sensory or direct nature. The feedback signals are determined by a multivariate analysis that takes into consideration how measured variables compare with predefined criteria, thus producing a statistical correlation in real-time, in conjunction with a reference or normative database, rule-set, algorithm, discriminate function, or classification system.