Abstract: The present application provides materials and methods for treating a patient with Alpha-1 antitrypsin deficiency (AATD) both ex vivo and in vivo. In addition, the present application provides materials and methods for editing the SERPINA1 gene in a cell by genome editing.

Abstract: A pituitous silicone fluid includes a hydrosilylation reaction product and a carrier fluid. The hydrosilylation reaction product is the reaction product of a first linear organopolysiloxane and a second linear organopolysiloxane. The first linear organopolysiloxane includes (R1R2R3SiO1/2) and (R4R5SiO2/2) units. Each of R1-R5 is independently a hydrocarbon group so long as at least one of R1-R5 is an alkenyl group. In addition, the first linear organopolysiloxane has a degree of polymerization of from 100 to 15,000. The second linear organopolysiloxane includes (R6R7R8SiO1/2) and (R9R10SiO2/2) units. Each of R6-R10 is independently a hydrocarbon group, polyether group, siloxane group, or polyol group, so long as at least one of R6-R10 is a hydrogen atom. In addition, the second linear organopolysiloxane has a degree of polymerization of from 4 to 1,000. The hydrosilylation reaction product includes alkenyl or Si—H functionality. Personal care compositions can include the pituitous silicone fluid.

Abstract: A baby changing apparatus. The baby changing apparatus includes a pad having an upper surface, a lower surface, a first side and a second side. A first connector is disposed on the first side. A privacy shield includes a proximal end joined to and extending from the first side of the pad and a distal end. A second connector is coupled to the distal end. The privacy shield is configured to fold over itself and the pad such that the second connector releasably connects to the first connector and the privacy shield forms a tube shape in a deployed position.

Abstract: Methods and apparatus to provision cloud computing network elements are disclosed. A disclosed example method includes receiving a selection of a cloud networking template from a client, wherein the cloud networking template includes a data center connector type and a wide area network connector type, configuring a virtual machine on a host server based on the cloud networking template, configuring a data center connector based on the data center connector type, configuring a wide area network connector based on the wide area network connector type, and coupling the wide area network connector to the data center connector and coupling the data center connector to the virtual machine within the host server to enable the client to access the virtual machine.

Abstract: A system and method for using an universal remote control to access extended operational functions of a device. A consumer causes the universal remote control to transmit a code data value selected from the library to a target device while observing the effect of the transmitted code data value on the target device. When the target device responds in a manner desired by the consumer, the consumer may tag the code data value that caused the desired effect and assign the tagged code data value to a programmable key on the universal remote control.

Abstract: The present application provides materials and methods for treating hemoglobinopathies. More specifically, the application provides methods for producing progenitor cells that are genetically modified via genome editing to increase the production of fetal hemoglobin (HbF), as well as modified progenitor cells (including, for example, CD34+ human hematopoietic stem cells) producing increased levels of HbF, and methods of using such cells for treating hemoglobinopathies such as sickle cell anemia and ?-thalassemia.

Abstract: The present disclosure relates to injectable compositions and methods of making injectable compositions of moisture curing siloxane polymers for forming accommodating intraocular lenses. In certain embodiments, the moisture curing siloxane polymers are comprised of an organosilicon compound and a hydrolytically sensitive siloxane moiety and have a specific gravity of greater than about 0.95, a number average molecular weight (Mn) greater than about 5,000 or about 20,000 and a weight average molecular weight (Mw) greater than about 20,000 or about 40,000. The disclosure includes accommodating intraocular lenses formed from moisture curing siloxane polymers and having a modulus of elasticity of less than about 6 kPa, less than 20% post-cure extractables, refractive index ranging from 1.4 to 1.5 and dioptric range of accommodation of OD to 10D.

Abstract: A heat-assisted magnetic recording (HAMR) head has a protective multilayer confined to a window of the disk-facing surface of the slider that surrounds the near-field transducer (NFT) end and write pole end. The protective multilayer is made up of alternating films of a metal and diamond-like carbon (DLC). All of the metal films are formed of the same metal selected from Ti, Zr, Hf, V, Nb, Ta, Cr, Mo and W, with the preferred metal being zirconium (Zr). A slider protective overcoat may be formed over the entire disk-facing surface in both the window region and the non-window region, with the protective multilayer formed on the slider overcoat in the window region. The overcoat may be absent in the window region, in which case an adhesion film is on the NFT and write pole ends in the window region, with the protective multilayer being formed on the adhesion film.

Abstract: An aminosiloxane polymer includes at least one Si-bonded functional group. This functional group has the chemical formula: —(R—NH)aR1—N(R2)—CH(—COOH)(—R3—C(?O)—NR42) (I). In Formula (I), R is a C1-C10 hydrocarbon group. R1 is a C1-C10 hydrocarbon group. R2 is a hydrogen atom, a C1-C12 hydrocarbon group, or a phenyl group. R3 is a C1-C4 hydrocarbon group. Each R4 is independently a hydrogen atom, a C1-C12 hydrocarbon group, a C1-C12 hydroxyl-hydrocarbon group, or a phenyl group. Moreover, “a” is 0 or 1, such that (R—NH) is optional. The aminosiloxane polymer can be formed using the method of this disclosure and can be formed in, and/or included in, the emulsion of this disclosure.

Abstract: A heparin mimicking polymer, its conjugate with bFGF, and method of making and using the same are disclosed. In particular, described herein are conjugates of biologic agents (e.g., bFGF) and heparin mimicking polymers having superior stability while retaining full native activity after a variety of stressors.

Abstract: A method for measuring boron concentration and an apparatus for performing the method are provided. The boron concentration measuring apparatus includes a reaction unit, an injection unit, a power supply unit, an electric current meter, a pH measuring device and an analysis unit to calculate the boron concentration with high reliability by calculating a mole concentration of boron ions through the analysis unit through calculating the titration time and the current amount during the titration time.

Abstract: Disclosed are compositions and methods for protecting hair against heat comprising applying to hair compositions containing silicone and silicone polyether copolymers with groups having amino, hydroxyl and/or alkoxy functionalities.

Abstract: A portable digital patient assistant (PDPA) includes an RFID reader implemented to read an RFID tag associated with patient use of medicinal drugs. The PDPA further includes a central processing unit for processing signals received from the RFID reader. The PDPA further includes a memory for storing data about the medicinal drugs, with the memory being operatively associated with the central processing unit. The PDPA further includes an output operatively linked to the central processing unit to provide output information regarding the use of medicinal drugs.

Abstract: A coil tubing spool handling device includes a base structure and a vertical support structure. The base structure includes an upper surface, a lower surface, and a rocker portion with a curved surface to allow the base structure to rotate along the curved surface. The vertical support structure is connected to the base structure proximate the rocker portion, and extends substantially perpendicular to the upper surface. The vertical support structure and the upper surface can receive a coil tubing spool. A center of rotation of the rocker portion is located in a forward location relative to a center of gravity of the device when the vertical support structure and upper surface receive the coil tubing spool. The relative positions of the center of gravity and the center of rotation bias the handling device to rotate from a vertical position to a horizontal position.

Abstract: A heparin mimicking polymer, its conjugate with bFGF, and method of making and using the same are disclosed. In particular, described herein are conjugates of biologic agents (e.g., bFGF) and heparin mimicking polymers having superior stability while retaining full native activity after a variety of stressors.

Abstract: A fluid composition comprises I) a first component and II) second component different from the first component I). The first component I) comprises at least one copolymer. The copolymer can include a cross-linked siloxane (e.g. a cross-linked aminosiloxane), a silicone polyether copolymer (e.g. an (AB)n silicone polyether copolymer), and/or a saccharide siloxane copolymer. The second component II) comprises an organopolysiloxane resin (e.g. an MQ resin) and/or an acrylate copolymer. The fluid composition can further comprise a carrier fluid, such as a silicone, an organic solvent, and/or an organic oil. The fluid composition may have a viscosity of at least 100 mPa·s at 23° C. and exhibit pituitous rheological properties (generally determined from a plot of normal force (in Pascals) vs a perpendicular shear rate in (sec?1)). Also disclosed is a personal care composition that comprises the fluid composition.

Abstract: An aminosiloxane polymer includes at least one Si-bonded functional group. This functional group has the chemical formula: —(R—NH)aR1—N(R2)—CH(—COOH)(—R3—C(?O)—NR42) (I). In Formula (I), R is a C1-C10 hydrocarbon group. R1 is a C1-C10 hydrocarbon group. R2 is a hydrogen atom, a C1-C12 hydrocarbon group, or a phenyl group. R3 is a C1-C4 hydrocarbon group. Each R4 is independently a hydrogen atom, a C1-C12 hydrocarbon group, a C1-C12 hydroxyl-hydrocarbon group, or a phenyl group. Moreover, “a” is 0 or 1, such that (R—NH) is optional. The aminosiloxane polymer can be formed using the method of this disclosure and can be formed in, and/or included in, the emulsion of this disclosure.

Abstract: A method of laser processing a workpiece, the method comprising focusing a pulsed laser beam into a laser beam focal line directed into the workpiece, the laser beam focal line generating an induced absorption within the material, and the induced absorption producing a defect line along the laser beam focal line within the workpiece, wherein the focal line has length L and a substantially uniform intensity profile such that the peak intensity distribution over at least 85% of the length L of the focal line does not vary by more 40%, and preferably by no more than 30 or 20% from its mean peak intensity.

Abstract: A cross-linked aminosiloxane polymer includes a first siloxane backbone, a second siloxane backbone, and at least one intramolecular structure cross-linking a silicon atom of the first siloxane backbone and a silicon atom of the second siloxane backbone. The intramolecular structure has the chemical structure: (I) In Formula (I), X is chosen from the following groups; (II); (III); or (IV). In groups (II), (III), and (IV), each R is independently a C1-C10 hydrocarbon group. Each R1 is independently a C1-C10 hydrocarbon group. Each R2 is independently a hydrogen atom, OH, a C1-C12 hydrocarbon group, a phenyl group, R?(OR?)m, or R?OH. Each of R? and R? is independently an alkyl group and “m” is 1 to 3. Moreover, “a” is 0 or 1. The cross-linked aminosiloxane polymer can be formed by the method of this disclosure.

Abstract: Disclosed herein are systems, methods, and computer readable-media for providing an automatic synthetically generated voice describing media content, the method comprising receiving one or more pieces of metadata for a primary media content, selecting at least one piece of metadata for output, and outputting the at least one piece of metadata as synthetically generated speech with the primary media content. Other aspects of the invention involve alternative output, output speech simultaneously with the primary media content, output speech during gaps in the primary media content, translate metadata in foreign language, tailor voice, accent, and language to match the metadata and/or primary media content. A user may control output via a user interface or output may be customized based on preferences in a user profile.