Abstract: The present invention relates generally to a method of treating a neoplastic condition and to agents useful for same. More particularly, the present invention is directed to a method of facilitating the treatment of a solid tumour in a localised manner via the co-administration of particulate material and a cellular toxin. The method of the present invention is useful in a range of therapeutic treatments including the treatment of primary and metastatic tumours.

Abstract: The present invention relates generally to a method of treating a neoplastic condition and to agents useful for same. More particularly, the present invention is directed to a method of facilitating the treatment of a solid tumor in a localized manner via the co-administration of particulate material and a cellular toxin. The method of the present invention is useful in a range of therapeutic treatments including the treatment of primary and metastatic tumors.

Abstract: The present invention relates generally to a method of treating a neoplastic condition and to agents useful for same. More particularly, the present invention is directed to a method of facilitating the treatment of a solid tumour in a localised manner via the co-administration of particulate material and a cellular toxin. The method of the present invention is useful in a range of therapeutic treatments including the treatment of primary and metastatic tumours.

Abstract: The present invention relates generally to a method of treating a neoplastic condition and to agents useful for same. More particularly, the present invention is directed to a method of facilitating the treatment of a solid tumor in a localised manner via the co-administration of particulate material and a cellular toxin. The method of the present invention is useful in a range of therapeutic treatments including the treatment of primary and metastatic tumors.

Abstract: The present invention relates to a composition suitable for administration to a subject, the composition comprising pharmacologically acceptable particulate material dispersed throughout a pharmacologically acceptable liquid carrier, the particulate material being maintained in the dispersed state by a steric stabilizer, wherein the steric stabilizer is a polymeric material comprising a steric stabilizing polymeric segment and an anchoring polymeric segment, one or both of which are derived from one or more ethylenically unsaturated monomers that have been polymerized by a living polymerization technique, wherein the steric stabilizing polymeric segment is different from the anchoring polymeric segment, and wherein the anchoring polymeric segment has an affinity toward the surface of the particulate material and secures the stabilizer to the particulate material.

Abstract: The present invention relates to a method of forming polymer on the surface of polymer particles, the method comprising: (i) providing a dispersion comprising a continuous aqueous phase, a dispersed organic phase comprising one or more ethylenically unsaturated monomers, and a RAFT agent as a stabiliser for said organic phase; (ii) polymerising the one or more ethylenically unsaturated monomers under the control of the RAFT agent to form an aqueous dispersion of seed polymer particles; (iii) crosslinking the seed polymer particles; (iv) swelling the crosslinked seed particles with one or more ethylenically unsaturated monomers to form an aqueous dispersion of monomer swollen crosslinked seed polymer particles; (v) increasing the temperature of the monomer swollen crosslinked seed polymer particles to expel at least some of the monomer therein onto the surface of the particles; and polymerising at least the expelled monomer to form polymer on the surface of the particles.

Abstract: The invention provides a method of preparing an aqueous dispersion of vesiculated polymer particles, the method comprising: preparing a dispersion of polymerisable particles within a continuous aqueous phase, the polymerisable particles having a structure that is defined by an outer organic phase that comprises one or more ethylenically unsaturated monomers and surrounds an inner aqueous phase, said inner aqueous phase defining a single void within the polymerisable particle, wherein a RAFT agent functions as a stabiliser for the outer organic phase within the continuous aqueous phase, and wherein a RAFT agent functions as a stabiliser for the inner aqueous phase within the outer organic phase; and polymerising the one or more ethylenically unsaturated monomers under the control of a RAFT agent functioning as said stabiliser to form the aqueous dispersion of vesiculated polymer particles.