Abstract: Provided is a preparing method of linear carbonate compounds, including performing a coupling reaction of carbon dioxide in the presence of a titanium dioxide complex. The titanium dioxide complex includes an anatase phase and a rutile phase, a reduced titanium dioxide which is formed by selectively reducing any one of the anatase phase and the rutile phase, and a metallic oxide bound to the reduced titanium dioxide.

Abstract: The invention is based on a method for processing an X-ray and gamma-ray radiation spectrum acquired by a spectrometry device (1). The processing method takes into consideration a spectral dispersion matrix (D). The spectral dispersion matrix models the energy response of the device. The method comprises establishing a transfer matrix (U,U?,D?), using the spectral dispersion matrix. The transfer matrix is then used to establish a direct model, linking measured variables, forming an input vector (m), and variables to be estimated, forming an output vector. The invention of the direct model allows the output vector (a,s,h,?) to be estimated. The invention may be applied to quantifying the activity of an object to be inspected or to performing an energy or efficiency calibration of the spectrometry device. FIG. 2B.

Abstract: The invention is a method for processing a calibration spectrum acquired by a spectrometric detector of X or gamma photons. The method comprises a taking into account of a parametric form of a calibration function, the calibration function linking the rank of an energy channel to an energy value. The method comprises a confrontation between the channels of the peaks of the calibration spectrum and emission energies of calibration isotopes. The confrontation makes it possible to define the values of the parameters of the calibration function.

Abstract: The present invention provides antibody drug conjugates, wherein an antibody or antibody fragment that specifically binds to human cKIT is linked to a drug moiety, optionally through a linker. The present invention further provides pharmaceutical compositions comprising the antibody drug conjugates; and methods of making and using such pharmaceutical compositions for ablating hematopoetic stem cells in a patient in need thereof.

Abstract: A phospholipid composition obtained from the process of forming a homogeneous mixture by mixing (A) a lecithin extract ingredients from egg yolk with (B) a lecithin extract ingredients from plants in a predetermined ratio of (1-3): (1-3); and then adjusting moisture of the homogeneous mixture below 10%. In addition, the invention also discloses the phospholipid composition applied to make the nano liquid product containing curcumin have the ability to treating burns and increasing the effect of scar healing; wherein the product is used at a dose of 0.05-0.1 mL/cm2 of skin, with a frequency of twice daily to reduce the area of the burns, and increasing the concentration of hydroxyproline in the skin.

Abstract: The disclosure relates to double stranded ribonucleic acid (dsRNAi) agents and compositions targeting a SNCA gene, particularly in a CNS tissue, as well as methods of inhibiting expression of a SNCA gene and methods of treating subjects having a SNCA-associated neurodegenerative disease or disorder, e.g., Parkinson's Disease (PD), multiple system atrophy (MSA), Lewy body dementia (LBD), among other synucleinopathies, using such dsRNAi agents and compositions.

Abstract: Environmental indicators for monitoring a predetermined environmental exposure, for example, an historical heat exposure such as a cumulative ambient heat exposure and/or a peak ambient heat exposure, may include an environmental indicator material. The environmental indicator may be configured to attach to a host product for monitoring the predetermined environmental exposure of the host product.

Abstract: In some examples, an embolic protection system is provided for deploying a device in a diseased vessel of a vasculature, the embolic protection system comprising: an embolic protection device (EPD) including: an EPD shaft; a dual-hoop filter provided at a distal end of the EPD shaft, the dual-hoop filter including a distal hoop provided at a distal end of the dual-hoop filter, and a proximal hoop provided at a proximal end of the dual-hoop filter; and a filter actuator located at or towards a proximal end of the EPD, the filter actuator operable to selectively open or close the distal hoop and the proximal hoop of the dual-hoop filter.

Abstract: The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.

Abstract: The invention relates to a process for producing an aqueous solution of 5-hydroxymethylfurfural (5-HMF), comprising: a step a) of placing a feedstock comprising 5-HMF and dimethyl sulfoxide (DMSO) in contact with an intermediate aqueous back-extract obtained from step c), to obtain an aqueous mixture, a step b) of liquid-liquid extraction of the aqueous mixture with a stream of extraction solvent, to produce an aqueous raffinate and an intermediate organic extract, a step c) of back-washing of the intermediate organic extract with an aqueous solvent, to produce the intermediate aqueous back-extract and an organic raffinate, a step d) of liquid-liquid back-extraction of the organic raffinate obtained on conclusion of step c) with an aqueous stream, to produce an organic effluent and an aqueous back-extract of 5-HMF.

Abstract: Aspects of the present disclosure describe integrated-optics-based phase controllers comprising waveguides whose cores have one or more cavities, thereby enabling them to exhibit an enhanced photo-elastic effect and/or increased stress-induced deformation in at least one region. Waveguides in accordance with the present disclosure are particularly well suited for use in stress-optic phase controllers suitable for use in systems such as microwave photonics, LIDAR and the like.

Abstract: A networked computer system providing an automated control system that enables a sensor client to securely communicate with a heterogeneous set of unique sensors. The system enables autonomous secure identification of specific sensors capable of system inter-operation. Recognized sensors are autonomously paired and the connection secured using a password unique to the sensor and autonomously managed by the system. Measurement data is source encrypted using a well-defined public key, thereby providing data security that extends uninterrupted from the sensor itself to an appropriately authorized subsystem of the control system.

Abstract: The present invention is related to a use of prochlorperazine (PCP), or analog thereof for treating a cancer in a subject by influencing membrane proteins and receptors and inducing alterations in the expressions of the surface marker on cancer cells and their derived extracellular vesicles. The invention method offers a novel approach for the treatment and diagnosis of cancer and metastasis. Specific surface markers serve as a potential candidate for cancer-associated extracellular vesicles (EVs) and have applications in diagnosis, prognosis, and therapeutic targeting.

Abstract: The present invention is in the field of molecular hydrogen (H2) bio-production, particularly, the present invention provides genetically modified photosynthetic microalgae producing hydrogen in complete growth medium under ambient, continuous growth conditions at cost-effective amounts and to a process for hydrogen production using genetically modified photosynthetic microalga.

Abstract: A path finding apparatus acquires vehicle information and map information, and determines a path set that includes a path for each of the vehicles in the vehicle set. The path set is determined using the vehicle information and the map information. The paths in the path set do not conflict with each other. To determine the path set, the path finding apparatus performs a path planning algorithm to generate the path for each of the vehicles. The path planning algorithm evaluates the path based on a utility score of the path that is a scalar value representing how much the path achieves a plurality of objectives.

Abstract: The present invention refers to fabrication method of a membrane electrode assembly (MEA), to MEA obtainable by said method, to a cell comprising said MEA, to the use of the MEA and the cell for the electrochemical detection of analytes, and to the use of the MEA and the cell for storing and/or delivering electricity.

Abstract: A method of operation of a compute system includes: qualifying a patient image for analyzing a suspected skin condition; detecting a skin area in the patient image; segmenting the skin area into a segmented image including the suspected skin condition; cropping the segmented image to form a cropped image including the suspected skin condition at a center of the cropped image; analyzing the suspected skin condition to identify a skin disease result and a disease subclass from the cropped image; and assembling a disease identification display including the patient image, a skin disease indication, an image match score, and the disease subclass for displaying on a device.

Abstract: Provided herein are antibodies that specifically bind to human tissue factor (TF), anti-TF antibody-drug conjugates (ADCs), and compositions comprising the antibodies or ADCs. Also provided herein are methods of making and using the antibodies or ADCs, such as therapeutic and diagnostic methods.

Abstract: A bone plate includes a plate body defining an outer surface, an opposed bone-facing surface, and a combination hole comprising a locking hole and a compression hole that intersect one another and each extending from the outer surface to the bone-facing surface. The locking hole and the compression hole extend away from each other along a longitudinal axis. The plate body further defines a locking surface that defines the locking hole, and a second surface that defines the compression hole. The locking surface further defines a plurality of columns sequentially located about a central axis of the locking hole, a plurality of recesses located, respectively, between at least some of the columns, and plate threads that traverse each of the columns. Crests of the plate threads extend linearly from a first side of each column to a second side of each column.

Abstract: A document transport device includes an ejection tray on which documents ejected in a predetermined ejection direction are loaded and a stopper that prevents documents from falling from the ejection tray in the ejection direction. The stopper has a rotating shaft rotatably supported at the ejection tray in a direction intersecting the ejection direction, a contact piece provided at the rotating shaft to be hit by a tip of a document in the ejection direction, and a weight piece provided at the rotating shaft. The stopper is able to pivot to be in a standing posture in which the contact piece stands due to the weight of the weight piece and pivot to be in a tilting posture in which the stopper tilts in the ejection direction from the standing posture when a predetermined force is applied to the contact piece.