Abstract: An improved method for treatment of an individual suffering from or at risk for an infectious disease, comprising administering to said individual a combination of from two to five agents is disclosed. The agents may be agents that mobilize dendritic cells, agents that cause death or growth inhibition of infectious agents, chemoattractants, agents that stimulate maturation of dendritic cells, and agents that enhance an immune response of an effector T cell. Antigen-expressing, activated dendritic cells are disclosed. Such dendritic cells are used to present antigens (specifically, antigens derived from infectious agents) to T cells, and can be useful in vaccination protocols. Useful cytokines can be used in separate sequential or simultaneous combination with the activated, antigen-pulsed dendritic cells. Also disclosed are methods for stimulating an immune response using the antigen-expressing, activated dendritic cells.

Abstract: An improved method for treatment of a tumor bearing subject comprising administering to said subject a combination of from two to five agents is disclosed. The agents may be agents that mobilize dendritic cells, agents that cause apoptosis and/or necrosis of tumor cells, chemoattractants, agents that stimulate maturation of dendritic cells, and agents that enhance an anti-tumor response of a T cell.