Patents by Inventor Thien V. Truong

Thien V. Truong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of mono- and bis(phosphocholine) derivatives which have antifungal activity
    Patent number: 5811568
    Abstract: This invention pertains to a synthetic process for obtaining a unique phosphocholine derivative which has been isolated from the leaves of the plant Irbachia alata, identified to be 1,22-bis?2-(trimethylammonium)ethylphosphatyl! docosane is disclosed. Also disclosed is a synthetic process for obtaining a novel class of mono- and bis(phosphocholine) derivatives which are useful as antiinfective agents. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: September 22, 1998
    Assignee: Shaman Pharmaceuticals, Inc.
    Inventors: Donald E. Bierer, Jeffrey M. Dener, Thien V. Truong
  • 1,2-dithiin antiinfective agents
    Patent number: 5668168
    Abstract: This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans or Aspergillus fumigatus.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: September 16, 1997
    Assignees: Shaman Pharmaceuticals, Inc., The Regents of the University of Michigan
    Inventors: Thien V. Truong, Donald E. Bierer, Jeffrey M. Dener, Richard Hector, Michael S. Tempesta, Bernard Loev, Wu Yang, Masato Koreeda
  • N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT)
    Patent number: 5656634
    Abstract: Compounds of the formula ##STR1## the pharmaceutically acceptable salts thereof, wherein Q and R.sup.1 are as defined below, and novel carboxylic acid and acid halide intermediates used in the synthesis of such compounds. The compounds of formula I are inhibitors of acyl coenzyme A: cholesterol acyltransferase (ACAT) and are useful as hypolipidemic and antiatherosclerosis agents.
    Type: Grant
    Filed: May 31, 1994
    Date of Patent: August 12, 1997
    Assignee: Pfizer Inc.
    Inventors: George Chang, Ernest S. Hamanaka, Peter A. McCarthy, Thien V. Truong, Frederick J. Walker
  • Preparation of symmetrical and unsymmetrical 3,6-disubstituted-1,2-dithiins having antifungal activity
    Patent number: 5583235
    Abstract: The present invention provides an improved procedure for the preparation of 3,6-disubstituted-1,2-dithiin derivatives, especially unsymmetrical 1,2-dithiins. In addition, the process offers significant process, scaleup, and safety advantages over the previously reported synthetic processes. The compounds synthesized by this new process and described herein are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus, Trichophyton rubrum, Candida parapsilosis, Candida tropicalis, or Candida krusei.
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: December 10, 1996
    Assignee: Shaman Pharmaceuticals, Inc.
    Inventors: Donald E. Bierer, Jeffrey M. Dener, Thien V. Truong
  • 1,2-dithiin antiinfective agents
    Patent number: 5556875
    Abstract: This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans or Aspergillus fumigatus.
    Type: Grant
    Filed: August 24, 1995
    Date of Patent: September 17, 1996
    Assignees: Shaman Pharmaceuticals, Inc., The Regents of the University of Michigan
    Inventors: Thien V. Truong, Donald E. Bierer, Jeffrey M. Dener, Richard Hector, Michael S. Tempesta, Bernard Loev, Wu Yang, Masato Koreeda