Abstract: A method of diagnosing an MSI cancer in a patient including extracting and sequencing DNA from a tumoral sample and if available from a normal sample and operate an analyse of MNRs. The method is based on the demonstration that the FDA-approved NGS-based diagnostic test for identifying MSI in mCRC and nmCRC gave inaccurate results when compared with the gold standard reference methods. Consequently, whole exome sequencing (WES) data from all samples was further analyzed to improve detection of the MSI genomic signal in CRC and other primary tumor types. This allowed identification of weaknesses and limits of MSISensor and the design and validation of a newly optimized algorithm, namely MSICare. The high accuracy of MSICare for the detection of MSI in CRC and non-CRC tumors should allow it to become a future reference test for assessing MSI in pan-cancer.

Abstract: A handheld laser trimming and welding device can include a handheld laser trimming and welding wand and a nozzle. The nozzle can extend from the handheld laser trimming and welding wand to a distal portion, and the nozzle can have an aperture on the distal portion. The distal portion of the nozzle can be configured to optically communicate a laser to the distal portion of the nozzle and fluidically communicate a pressurized gas to the distal portion of the nozzle.

Abstract: A method of additive manufacturing can include forming a machine part having a first portion formed from a cast iron material; forming a second portion adjacent the first portion formed of a combination of the cast iron material and a different material; and forming a third portion adjacent the second portion formed of only the different material, wherein the third portion is located at a predetermined critical area of the machine part.

Abstract: The present invention relates to methods for determining, modulating or adjusting a treatment regimen with a chemotherapeutic agent in a patient affected with a cancer.

Abstract: A method of additive manufacturing can include forming a machine part having a first portion formed from a cast iron material; forming a second portion adjacent the first portion formed of a combination of the cast iron material and a different material; and forming a third portion adjacent the second portion formed of only the different material, wherein the third portion is located at a predetermined critical area of the machine part.

Abstract: The present invention relates to methods for predicting the survival time of patients suffering from a micro satellite unstable cancer. In particular, the present invention relates to a method for predicting the survival time of a patient suffering from a micro satellite unstable cancer comprising i) determining the expression level of at least one gene encoding for an immune checkpoint protein in a tumor tissue sample obtained from the patient, ii) comparing the expression level determined at step i) with a predetermined reference value and iii) concluding that the patient will have a long survival time when the level determined at step i) is lower than the predetermined reference value or concluding that the patient will have a short survival time when the level determined at step i) is higher than the predetermined reference value.

Abstract: An end joining piece (4) for a windscreen wiper for a glazed surface of a motor vehicle is disclosed. The end piece has at least a receipt receptacle (410) for receiving an end part of a longitudinal vertebra (20), and at least one flexible tongue (6a, 6b) which is configured to go from a first, position of rest, to a second, retracted position, by displacement in a first direction (F2a, F2b) during the insertion of the longitudinal vertebra in the receipt receptacle (410), the flexible tongue including an engagement ramp along which the vertebra is made to thrust, to provide the tongue with its second, retracted position. The engagement ramp (620a, 620b) has an inclination which is configured to exert on the longitudinal vertebra a force which tends to displace this vertebra in a second direction (F3a, F3b), which, together with the first direction of displacement, forms a non-zero angle.

Abstract: A poppet valve has an elongated stem that is configured to extend along a longitudinal axis. The poppet valve further includes a valve body that is disposed laterally with respect to the longitudinal axis and located in a spaced apart relation with an end of the elongated stem. The valve body has a pair of opposing faces disposed co-axial with the longitudinal axis of the elongated stem. The poppet valve also includes at least two arcuately shaped appendages depending downwardly from the end of the elongated stem and extending away from the longitudinal axis of the elongated stem. An end of each appendage is disposed in abutment with an annular region defined on one of the opposing faces of the valve body, a perimeter of the annular region being larger than a perimeter of the elongated stem measured about the longitudinal axis.

Abstract: A method for evaluating part for additive manufacturing is provided. The method includes receiving data related to a set of printability factors associated with the part. The set of printability factors comprise at least: an availability of a three dimensional printer, a build density, a fraction of part to be printed, a print accuracy, a part complexity, and a number of parts needed. The method includes evaluating a printability index associated with the part based on at least three printability factors from the set of printability factors. Further, the method includes displaying the printability index associated with the part for the evaluation of the part for additive manufacturing.

Abstract: A system for manufacturing a Three Dimensional (3D) printed component is provided. The system includes a substrate adapted for at least partially 3D printing the component thereon. The substrate includes a first geometrical feature. The system also includes a plurality of processing stations interconnected to one another. Each of the plurality of processing stations is adapted to receive the substrate. Each of the plurality of processing stations includes a second geometrical feature adapted to interlock with the first geometrical feature.

Abstract: An end joining piece (4) for a windscreen wiper for a glazed surface of a motor vehicle is disclosed. The end piece has at least a receipt receptacle (410) for receiving an end part of a longitudinal vertebra (20), and at least one flexible tongue (6a, 6b) which is configured to go from a first, position of rest, to a second, retracted position, by displacement in a first direction (F2a, F2b) during the insertion of the longitudinal vertebra in the receipt receptacle (410), the flexible tongue including an engagement ramp along which the vertebra is made to thrust, to provide the tongue with its second, retracted position. The engagement ramp (620a, 620b) has an inclination which is configured to exert on the longitudinal vertebra a force which tends to displace this vertebra in a second direction (F3a, F3b), which, together with the first direction of displacement, forms a non-zero angle.

Abstract: The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides.

Abstract: The present invention relates to genetic control of infestation by insect pest species, particularly prevention and/or control of pest infestation of plants, using interfering ribonucleic acid (RNA) molecules. Compositions and combinations containing the interfering RNA molecules of the invention for use in topical applications, for example in the form of insecticides.

Abstract: The present invention concerns concatemer and/or stabilized RNA constructs capable of forming dsRNA, optionally comprising a sequence capable of protecting the dsRNA against RNA processing in a host cell. The invention also relates to methods of producing these constructs and to methods for using these constructs. The constructs according to the present invention are particularly useful in plant pest control.

Abstract: The present invention relates to methods for predicting the survival time of patients suffering from a micro satellite unstable cancer. In particular, the present invention relates to a method for predicting the survival time of a patient suffering from a micro satellite unstable cancer comprising i) determining the expression level of at least one gene encoding for an immune checkpoint protein in a tumor tissue sample obtained from the patient, ii) comparing the expression level determined at step i) with a predetermined reference value and iii) concluding that the patient will have a long survival time when the level determined at step i) is lower than the predetermined reference value or concluding that the patient will have a short survival time when the level determined at step i) is higher than the predetermined reference value.

Abstract: A method of hardfacing a component includes generating a laser beam and directing the laser beam to an area of a wear surface of the component. The method includes feeding a flexible cord of a cladding material into the laser beam to melt the flexible cord and produce a bead of the cladding material on the wear surface. The flexible cord includes an inner metal wire surrounded by an agglomerate of abrasion and wear-resistant material that contains diamond particles. The method further includes moving the laser beam and the flexible cord along the wear surface to produce a cladding layer over the wear surface of the component.

Abstract: A method of manufacturing an undercarriage track joint assembly includes forming at least a first portion of a seal assembly by laser brazing an annular, metal sealing washer to a first track link of the undercarriage track joint assembly. The method may also include performing the laser brazing to form at least one of an annular fillet of braze material between the first track link and at least a portion of an inner diameter surface of the washer and an annular fillet of braze material between the first track link and at least a portion of an outer diameter surface of the washer.

Abstract: A poppet valve has an elongated stem that is configured to extend along a longitudinal axis. The poppet valve further includes a valve body that is disposed laterally with respect to the longitudinal axis and located in a spaced apart relation with an end of the elongated stem. The valve body has a pair of opposing faces disposed co-axial with the longitudinal axis of the elongated stem. The poppet valve also includes at least two arcuately shaped appendages depending downwardly from the end of the elongated stem and extending away from the longitudinal axis of the elongated stem. An end of each appendage is disposed in abutment with an annular region defined on one of the opposing faces of the valve body, a perimeter of the annular region being larger than a perimeter of the elongated stem measured about the longitudinal axis.